References
Ames BN, McCann J, Yamasaki E (1975) Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. Mutation Res 31: 347–364
Bhatt B (1977) Studies on chromosomal aberrations in field workers spraying pesticides. Abstract, Second Annual Conference of Environmental Mutagen Society of India, Bombay
Cabral JRP, Shubik P, Mollner T, Raitano F (1977) Carcinogenic activity of hexachlorobenzene in hamsters. Nature 269: 510–511
Chadwick RW, Copeland MF, Froehlich R, Cooke N (1983) Chlorobenzene-impaired metabolism and the effect of pretreatment with chlorobenzene, lindane or chlorobenzene plus lindane. J Toxicol Environ Health 12:559–610
Decloitre F, Chauveau J, Benoit A, Martin M (1975) Metabolisation et fixation in vitro par le DNA de thymus de veau et les proteines microsomiques de foie de rat de quelques pesticides organochlores et organophosphores. C R Acad Sci Paris, Ser D, 280: 1027–1030
Gopalaswamy UV, Aiyar AS (1984) Effects of lindane on liver mitochondrial function in the rat. Bull Environ Contam Toxicol 33: 106–113
Gopalaswamy UV, Aiyar AS (1988) Biotransformation and toxicity of lindane and its metabolite hexachlorobenzene in mammals. In Hexachlorobenzene: Proceedings of an International Symposium, Morris CR and Cabral JRP Eds. IARC Scientific Publications No.77, Lyon: 267–276
Grover PL, Sims P (1965) The metabolism of gamma-2,3,4,5,6-pentachlorocyclo-hex-1-ene and gamma-hexachlorocyclohexane in rats. Biochem J 96: 521–525
Iverson F, Ryan JJ, Lizotte R, Hierlihy SL (1984) In vivo and in vitro binding of alpha and gamma-hexachlorocyclohexane to mouse liver macromolecules. Toxicol Lett 20: 331–335
Khera KS (1974) Teratogenicity and dominant lethal studies on hexachlorobenzene in rats. Food Toxicol 12: 471–477
Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265–275
Lutz WK (1986) Quantitative evaluation of DNA binding data for risk estimation and for classification of direct and indirect carcinogens. J Canc Res Clin Oncol 112: 85–91
Macholz RM, Kujawa M (1985) Recent state of lindane metabolism. Part III Residue Rev 94: 119–149
Marmur J (1961) A procedure for the isolation of DNA from microorganisms. J Molec Biol 3: 208–218
Masini A, Stanzani DC, Tomasi A, Trenti T, Ventura E (1985) The role of pentachlorophenol in causing mitochondrial derangement in hexachlorobenzene induced experimental porphyria. Biochem Pharmacol 34: 1171–1174
Metcalf RL (1955) Organic insectisides. Interscience, Wiley, New York
Oesch F, Fridberg T, Herbst M, Paul W, Wilhelm N, Bentley P (1982) Effects of lindane treatment on drug metabolising enzymes and liver weight of CFI mice in which it evoked hepatomas and in nonsusceptible rodents. Chem Biol Interact 40: 1–14
Reuber MD (1979) Carcinogenicity of lindane. Environ Res 1: 460–481
Sagelsdorff P, Lutz WK, Schlatter C (1983) The relevance of covalent binding to mouse liver DNA to the carcinogenic action of hexachlorocyclohexane isomers. Carcinogenesis 4: 1267–1273
Shah GM, Bhattacharya RK (1982) In vivo effect of l-ascorbic acid on benzo(a)pyrene metabolite — DNA adduct formation in rat liver. J Bioscience 4: 263–268
Wright AS, Ahintonwa DA, Wooder MF (1977) Studies on interactions of dieldrin with mammalian liver cells at the subcellular level. Ecotox Environ Safety 1: 7–16.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Gopalaswamy, U.V., Nair, C.K.K. DNA binding and mutagenicity of lindane and its metabolites. Bull. Environ. Contam. Toxicol. 49, 300–305 (1992). https://doi.org/10.1007/BF00191771
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00191771