Skip to main content
SpringerLink
Log in

In vitro effect of aluminum chloride on choline acetyltransferase activity of the rat brain during postnatal growth

  • Published:
Bulletin of Environmental Contamination and Toxicology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  • Alfrey AC, LeGendre GR, Kaehny WD (1976) The dialysis encephalopathy syndrome. Possible aluminum intoxication. N Engl J Med 294: 184–188

    Google Scholar 

  • Andreoli SP, Bergstein JM, Sherrard DJ (1984) Aluminum intoxication from aluminum-containing phosphate binders in children with azotemia not undergoing dialysis. N Engl J Med 17: 1079–1084

    Google Scholar 

  • Atterwill CK, Prince AK (1978) Multiple forms of choline acetyltransferase and the high affinity uptake of choline in brain of developing and adult rats. J Neurochem 31: 719–725

    Google Scholar 

  • Badamchian M, Morrow Jr KJ, Caroll PT (1986) Immunological, isoelectric, hydrophobic and molecular weight differences between soluble and ionically membrane-bound fractions of choline o-acetyltransferase prepared from mouse and rat brain. Neurochem Int 9:409–421

    Google Scholar 

  • Bird TD, Stranahan BS, Sumi SM, Raskind M (1983) Alzheimer's disease: choline acetyltransferase activity in brain tissue from clinical and pathological subgroups. Ann Neurol 14: 284–293

    Google Scholar 

  • Candy JM, Oakley AE, Watt F, Grime GW, Klinowski J, Perry RH, Edwardson JA (1986) A role for aluminum, silicon and iron in the genesis of senile plaques. Modern trends in aging research. 147: 443–450

    Google Scholar 

  • Fonnum F (1975) A rapid radiochemical method for the determination of choline acetyltransferase. J Neurochem 24: 407–409

    Google Scholar 

  • Glowinski J, Iversen LL (1966) Regional studies of catecholamines in the rat brain. I. The disposition of (3H) norepinephrine, (3H) dopamine and (3H) dopa in various regions of the brain. J Neurochem 13: 655–669

    Google Scholar 

  • Hofstetter JR, Vincent I, Bugiani O, Ghetti B, Richter JA (1987) Aluminum-induced decrease in choline acetyltransferase, tyrosine hydroxylase, and glutamate decarboxylase in selected regions of rabbit brain. Neurochem Pathol 6: 177–193

    Google Scholar 

  • Ichikawa T, Hirata Y (1986) Organization of choline acetyltransferase containing structures in the forebrain of the rat. J Neurosci 6: 281–292

    Google Scholar 

  • King RG (1984). Do raised brain aluminum levels in Alzheimer's dementia contribute to cholinergic neural deficits? Med Hypotheses 14: 301–306

    Google Scholar 

  • Krishnan SS, Harrison JE, Crapper McLachlan DR (1987) Origin and resolution of the aluminum controversy concerning Alzheimer's neurofibrillary degeneration. Biol Tr Elem Res 13: 35–42

    Google Scholar 

  • Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the folin phenol reagent. J Biol Chem 193: 265–275

    CAS  PubMed  Google Scholar 

  • Malthe-Sorenssen D, Fonnum F (1972). Multiple forms of choline acetyltransferase in several species demonstrated by isoelectric focusing. Biochem J 127: 229–236

    Google Scholar 

  • Markwell MAK, Haas SM, Bieber LL, Tolbert NE (1978) A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples. Anal Biochem 87: 206–210

    Google Scholar 

  • McGeer PL (1984) Aging, Alzheimer's disease and the cholinergic system. Can J Physiol Pharmacol 62:741–754

    Google Scholar 

  • Milland JA, King RG, Rogers LJ (1986) Changes in aggressive behaviour and forebrain choline acetyltransferase activity in the chick following aluminum chloride administration. Asia Pacific J Pharmacol 1: 105–110

    Google Scholar 

  • Patel AJ, Hayashi M, Hunt A (1987) Selective persistent reduction in choline acetyltransferase activity in basal forebrain of the rat after thyroid deficiency during early life. Brain Res 422: 182–185

    Google Scholar 

  • Perl DP, Pendlebury WW (1986) Aluminum neurotoxicity. Potential role in the pathogenesis of neurofibrillary tangle formation. Can J Neurol Sci 13: 441–445

    Google Scholar 

  • Sofroniev MV, Eckenstein F, Thoenen H, Cuello AC (1982) Topography of choline acetyltransferase-containing neurons in the forebrain of the rat. Neurosci Lett 33: 7–12

    Google Scholar 

  • Yates CM, Simpson J, Russell D, Gordon A (1980) Cholinergic enzymes in neurofibrillary degeneration produced by aluminum. Brain Res 197: 269–274

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Centre des Sciences de l'Environnement (Neurotoxicologie) Université de Metz, 1 rue des Récollets, 1, Metz Cedex, France

    G. Cherroret & P. R. Lehr

  2. Laboratoire de Bilogie du Comportement, Faculté des Sciences, Université de Nancy, 1, Nancy, France

    D. Desor

Authors
  1. G. Cherroret
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. D. Desor
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. P. R. Lehr
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Cherroret, G., Desor, D. & Lehr, P.R. In vitro effect of aluminum chloride on choline acetyltransferase activity of the rat brain during postnatal growth. Bull. Environ. Contam. Toxicol. 52, 487–491 (1994). https://doi.org/10.1007/BF00194133

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00194133

Keywords

Search

Navigation