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Toxicity of acrylonitrile in a human neuroblastoma cell line and its effect on glutathione and glutathione-S-transferase

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References

  • Gilbert H. F. (1989) Thermodynamic and kinetic constraints of thiol/disulfide exchange involving glutathione redox buffers. In:Taniguchi N., Higashi T., Sakamoto Y., Meister A., (ed) Glutathione Centennial, molecular perspectives and clinical implications, Academic Press Inc., San Diego, p. 73.

    Google Scholar 

  • Guengerich F. P., Geiger L. E., Hogy L. L., Wright P. L. (1981) In vitro metabolism of Acrylonitrile to 2-cyanoethylene oxide reaction with glutathione and irreversible binding to proteins and nucleic acid. Cancer Res 41: 4925–4933

    Google Scholar 

  • Habig W. H., Pabst M. J., Jakoby W. B. (1974) Gluatathion S-transferases. J Biol Chem 249: 7130–7139.

    Google Scholar 

  • Hissin P. J., Hilf R. (1976) A fluorimetric method for determination of oxidized and reduced glutathione in tissues. Anal Biochem 74: 214–226.

    CAS  PubMed  Google Scholar 

  • IARC (1979) “The evaluation of carcinogenic risk of chemicals to humans”. IARC monographs Vol 19: 73–113.

    Google Scholar 

  • Lowry O. H., Rosebrough N. J., Farr A. L., Randall R. J. (1951) Protein measurements with the Folin phenol reagent. J Biol Chem 193: 265–275.

    CAS  PubMed  Google Scholar 

  • O'Berg M. T. (1980) Epidemiologic study of workers exposed to acrylonitrile. J Occup Med 22: 245–252.

    Google Scholar 

  • Parkinson A., Thomas P. E., Ryan D. E., Reik L. M., Safe S. H., Robertson L. W., Levin W. (1983) Differential time course of induction of rat liver microsomal cytochrome P450 isozymes and epoxide hydrolase by Aroclor 1254. Arch Biochem Biophys 255: 203–215.

    Google Scholar 

  • Paulet G., Desnos J. (1961) L'acrylonitrile: toxicité — mécanisme d'action thérapeutique. Arch Inst Pharmacodyn 131: 54–83

    Google Scholar 

  • Pilon D., Roberts A. E., Rickert D. E., (1988) Effect of glutathione depletion on the uptake of acrylonitrile vapors and on its irreversible association with tissue macromolecules. Toxicol Appl Pharmacol 95: 265–278.

    Google Scholar 

  • Spinedi A., Pacini L., Piacentini M., Melino G., Lully P., (1990) Arachidonic acid incorporation and redistribution in human neuroblastoma (SK-N-BE) cell phospholipids. J Neurochem 54: 778–782.

    Google Scholar 

  • Szabo S., Bailey K. A., Boor P. J., Jdeger R. J. (1977) Acrylonitrile and tissue glutathione: differential effect of acute and chronic interaction. Biochem Biophys Res Comm 79: 32–37

    Google Scholar 

  • Theodore C., Singh S. V., Hong T. D. Awasthi Y. C., (1985), Glutathione Stransferases of human brain. Biochem J 225: 375–382.

    Google Scholar 

  • Walum E., Peterson A. (1984) On the application of cultured neuroblastoma cells in chemical toxicity screening. J Toxicol Envir Health 13: 511–520.

    Google Scholar 

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Authors and Affiliations

  1. Department of Pharmacology, CNR Centre of Cytopharmacology, Milan, Italy

    D. Cova

  2. Institute of Pharmacology, Faculty of Sciences, University of Milan, Italy

    P. Fumagalli & A. Santagostino

Authors
  1. D. Cova
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  2. P. Fumagalli
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  3. A. Santagostino
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Cova, D., Fumagalli, P. & Santagostino, A. Toxicity of acrylonitrile in a human neuroblastoma cell line and its effect on glutathione and glutathione-S-transferase. Bull. Environ. Contam. Toxicol. 49, 886–891 (1992). https://doi.org/10.1007/BF00203163

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  • DOI: https://doi.org/10.1007/BF00203163

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