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Sleep: Effects of d- and l-amphetamine in man and in rat

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Abstract

Almost identical results are reported in man and in rat for the effects of the amphetamine isomers on polygraphically recorded sleep. In both species, dextro-amphetamine produces a significantly greater increase in waking time. In both species, the two isomers have equal effects in reducing desynchronized sleep time. These findings combined with other recent data suggest that dopamine plays a direct role in wakefulness while norepinephrine is related inversely to amounts of desynchronized sleep.

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Author notes

  1. Ernest Hartmann

    Present address: Tufts University School of Medicine, Medford, USA

Authors and Affiliations

  1. Sleep and Dream Laboratory, Boston State Hospital, IRR Building, 591 Morton Street, 02124, Boston, Mass, USA

    Ernest Hartmann & James Cravens

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  1. Ernest Hartmann
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  2. James Cravens
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Hartmann, E., Cravens, J. Sleep: Effects of d- and l-amphetamine in man and in rat. Psychopharmacology 50, 171–175 (1976). https://doi.org/10.1007/BF00430488

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  • DOI: https://doi.org/10.1007/BF00430488

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