Summary
Diffuse degenerative myeloencephalopathy resembling Alexander's disease in a tetraparetic 9-month-old Scottish terrier dog is described. There were widespread deposits of Rosenthal fibers throughout brain and spinal cord in subpial, subependymal, perivascular and white matter regions. A diffuse proliferation of pleomorphic astrocytes in the white matter and subependymal areas was also seen. Demyelination was not a salient feature of the disease.
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References
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Supported by the Scott-Ritchey Program and the Department of Pathology and Parasitology, Auburn University. Publication Number 1797
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Cox, N.R., Kwapien, R.P., Sorjonen, D.C. et al. Myeloencephalopathy resembling Alexander's disease in a Scottish terrier dog. Acta Neuropathol 71, 163–166 (1986). https://doi.org/10.1007/BF00687980
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DOI: https://doi.org/10.1007/BF00687980