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Decreased expression of the intercellular adhesion molecule E-cadherin in prostate cancer: Biological significance and clinical implications

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References

  1. Chiarodo A (ed): National Cancer Institute roundtable on prostate cancer: future research directions. Cancer Res 51: 2498–2505, 1991

    Google Scholar 

  2. Hynes RO: Integrins: versatility, modulation, and signalling in cell adhesion. Cell 69; 1: 11–25, 1992

    Google Scholar 

  3. Springer TA: Adhesion receptors of the immune system. Nature 346: 425–434, 1990

    Google Scholar 

  4. Bevilacqua M, Butcher E, Furie B, Furie B, Gallatin M, Harlan J, Kishimoto K, Lasky L, McEver R, Paulson J, Rosen S, Seed B, Springer T, Stoolman L, Tedder T, Varki A, Wagner D, Weissman I, Zimmerman G: Selectins: a family of adhesion receptors. Cell 67: 233, 1991

    Google Scholar 

  5. Takeichi M: The cadherins: cell-cell adhesion molecules controlling animal morphogenesis. Development 102: 639–655, 1988

    Google Scholar 

  6. Takeichi M: Cadherin cell adhesion receptors as a morphogenetic regulator. Science 251: 1451–1455, 1991

    Google Scholar 

  7. Fisher SJ, Cui T, Zhang L, Hartman L, Grahl K, Guo-Yang Z, Tarpey J, Damsky CH: Adhesive and degradative properties of human placental cytotrophoblast cellsin vitro. J Cell Biol 109: 891–902, 1989

    Google Scholar 

  8. Carter BS, Ewing CM, Ward WS, Treiger BF, Aalders TW, Schalken JA, Epstein JI, Isaacs WB: Allelic loss of chromosomes 16q and 10q in human prostate cancer. Proc Natl Acad Sci USA 87: 8751–6755, 1990

    Google Scholar 

  9. Bergerheim USR, Kunimi K, Collins VP, Ekman P: Deletion mapping of chromosomes 8, 10, and 16 in human prostate carcinoma. Genes, Chromosomes & cancer 3: 215–220, 1991

    Google Scholar 

  10. Ozawa M, Ringwald M, Kemler R: Uvomorulin-catenin complex formation is regulated by a specific domain in the cytoplasmic region of the cell adhesion molecule. Proc Natl Acad Sci USA 87: 4246–4250, 1990

    Google Scholar 

  11. Herrenknecht K, Ozawa M, Eckerskorn C, Lottspeich F, Lenter M, Kemler R: The uvomorulin-anchorage protein α catenin is a vinculin homologue. Proc Natl Acad Sci USA 88: 9156–9160, 1991

    Google Scholar 

  12. Nagafuchi A, Takeichi M: Cell binding function of E-cadherin is regulated by the cytoplasmic domain. EMBO J 7; 12: 3679–3684, 1988

    Google Scholar 

  13. Ozawa M, Engel J, Kemler R: Single amino acid substitutions in one Ca++ binding site of uvomorulin abolish the adhesive function. Cell 63: 1033–1038, 1990

    Google Scholar 

  14. Nose A, Nagafuchi A, Takeichi M: Expressed recombinant cadherins mediate cell sorting in model systems. Cell 54: 993–1001, 1988

    Google Scholar 

  15. Detrick RJ, Dickey D, Kintner CR: The effects of N-cadherin misexpression on morphogenesis in xenopus embryos. Neuron 4: 493–506, 1990

    Google Scholar 

  16. Fujimori T, Miyatani S, Takeichi M: Ectopic expression of N-cadherin perturbs histogenesis in xenopus embryos. Development 110: 97–104, 1990

    Google Scholar 

  17. Shimoyama Y, Hirohashi S, Hirano S, Noguchi M, Takeichi M, Abe O: Cadherin cell-adhesion molecules in human epithelial tissues and carcinomas. Cancer Res 49: 2128–2133, 1989

    Google Scholar 

  18. Heimark RL, Degner M, Schwartz SM: Identification of a Ca++-dependent cell-cell adhesion molecule in endothelial cells. J Cell Biol 110: 1745–1756, 1990

    Google Scholar 

  19. Inuzuka H, Redies C, Takeichi M: Differential expression of R- and N-cadherin in neural and mesodermal tissues during early chicken development. Development 113: 959–967, 1991

    Google Scholar 

  20. Napolitano E, Venstrom K, Wheeler EF, Reichardt LF: Molecular cloning and characterization of B-cadherin, a novel chick cadherin. J Cell Biol 113: 4: 893–905, 1991

    Google Scholar 

  21. Donalies M, Cramer M, Ringwald M, Starzinski-Powitz A: Expression of M-cadherin, a member of the cadherin multigene family, correlates with differentiation of skeletal muscle cells. Proc Natl Acad Sci USA 88: 8024–8028, 1991

    Google Scholar 

  22. Mege RM, Matsuzaki F, Gallin WJ, Goldberg J, Cunningham BA, Edelman G: Construction of epithelioid sheets by transfection of mouse sarcoma cells with cDNAs for chicken cell adhesion molecules. Proc Natl Acad Sci USA 85: 7274–7278, 1988

    Google Scholar 

  23. McNeil H, Ozawa M, Kemler R, Nelson WJ: Novel function of the cell adhesion molecule Uvomorulin as an inducer of cell surface polarity. Cell 62: 309–316, 1990

    Google Scholar 

  24. Jongen WMF, Fitzgerald DJ, Asamoto M, Piccoli C, Slaga TJ, Gros D, Takeichi M, Yamasaki H: Regulation of connexin 43-mediated gap junctional intercellular communication by Ca++ in mouse epidermal cells is controlled by E-cadherin. J Cell Biol 114; 3: 545–555, 1991

    Google Scholar 

  25. Behrens J, Birchmeier W, Goodman SL, Imhof BA: Dissociation of Madin-Darby canine kidney epithelial cells by the monoclonal antibody anti-arc-1: mechanistic aspects and identification of the antigen as a component related to uvomorulin. J Cell Biol 101: 1307–1315, 1985

    Google Scholar 

  26. Imhof BA, Vollmers HP, Goodman SL, Birchmeier W: Cell-cell interaction and polarity of epithelial cells: specific perturbation using a monoclonal antibody. Cell 35: 667–675, 1983

    Google Scholar 

  27. Schor SC, Schor AM, Winn B, Rushton G: The use of three-dimensional collagen gels for the study of tumor cell invasionin vitro: experimental parameters influencing cell migration into the gel matrix. Int J Cancer 29: 57–62, 1982

    Google Scholar 

  28. Mareel MM, Kint J, Meyvish C: Methods of study of the invasion of malignant C3H mouse fibroblasts into embryonic chick heartin vitro. Virchows Arch B cell pathol 30: 95–111, 1979

    Google Scholar 

  29. Frixen UH, Behrens J, Sachs M, Eberle G, Voss B, Warda A, Lochner D, Birchmeier W: E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells. J Cell Biol 113; 1: 173–185, 1991

    Google Scholar 

  30. Behrens J, Mareel MM, Van Roy FM, Birchmeier W: Dissecting tumor cell invasion: epithelial cell acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion. J Cell Biol 108: 2435–2447, 1989

    Google Scholar 

  31. Vleminckx K, Vakaet JrL, Mareel M, Fiers W, Van Roy F: Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role. Cell 66: 107–119, 1991

    Google Scholar 

  32. Mareel MM, Behrens J, Birchmeier W, De Bruyne GK, Vleminckx K, Hoogewijs A, Fiers W, Van Roy F: Downregulation of E-cadherin expression in Madin Darby canine kidney (MDCK) cells inside tumors of nude mice. Int J Cancer 47: 922–928, 1991

    Google Scholar 

  33. Isaacs JT, Hukku B: Nonrandom involvement of chromosome 4 in the progression of rat prostatic cancer. The prostate 13: 165–188, 1988

    Google Scholar 

  34. Bussemakers MJC, Van Moorselaar RJA, Giroldi LA, Ichikawa T, Isaacs JT, Debruyne FMJ, Schalken JA: Decreased expression of E-cadherin in the progression of rat prostatic cancer. Cancer Res 52: 2916–2922, 1992

    Google Scholar 

  35. Hashimoto M, Niwa O, Nitta Y, Takeichi M, Yokoro KAF: Unstable expression of E-cadherin adhesion molecules in metastatic ovarian tumor cells. Jpn J Cancer Res 80: 459–463, 1989

    Google Scholar 

  36. Umbas R, Schalken JA, Isaacs WB, Aalders TW, Carter BS, Karthaus HFM, Schaafsma HE, Debruyne FMJ: Decreased expression of E-cadherin in high grade prostate cancer. Cancer Res In press

  37. Eidelman S, Damsky CH, Wheelock MJ, Damjanof I: Expression of the cell-cell adhesion glycoprotein cell-CAM 120/80 in normal human tissues and tumors. Am J Pathol 135; 1: 101–110, 1989

    Google Scholar 

  38. Gleason DF: Histologic grading and clinical staging of prostatic carcinoma. In: Tannenbaum M (ed) Urologic Pathology: The prostate. Philadelphia: Lea & Febiger, 1977, pp 171–197

    Google Scholar 

  39. Ligtenberg MJL, Buijs F, Vos HL, Hilkens J: Suppression of cellular aggregation by high levels of episialin. Cancer Res 52; 8: 2318–2324, 1992

    Google Scholar 

  40. Mansouri A, Spuur N, Goodfellow PN, Kemler R: Characterization and chromosomal localization of the gene encoding the human cell adhesion molecule uvomorulin. Differentiation 38: 67–71, 1988

    Google Scholar 

  41. Sato T, Tanigami A, Yamakawa K, Akiyama F, Kasumi F, Sakamoto G, Nakamura Y: Allelotype of breast cancer: cumulative allele losses promote tumor progression in primary breast cancer. Cancer Res 50: 7184–7189, 1990

    Google Scholar 

  42. Sato T, Akiyama F, Sakamoto G, Kasumi F, Nakamura Y: Accumulation of genetic alterations and progression of primary breast cancer. Cancer Res 51: 5794–5799, 1991

    Google Scholar 

  43. Tsuda H, Zhang W, Shimosato Y, Yokota J, Terada M, Sugimura T, Miyamura T, Hirohashi S: Allele loss on chromosome 16 associated with progression of human hepato cellular carcinoma. Proc Natl Acad Sci USA 87: 6791–6794, 1990

    Google Scholar 

  44. Fugimori M, Tokino T, Hino O, Kitagawa T, Imamura T, Okamoto E, Mitsunobu M, Ishikawa T, Nakagawa H, Harada H, Yagura M, Matsubara K, Nakamura Y: Allelotype study of primary hepatocellular carcinoma. Cancer Res 51: 89–93, 1991

    Google Scholar 

  45. Thomas GA, Raffel C: Loss of heterozygosity on 6q, 16q, and 17p in human central nervous system primitive neuroectodermal tumors. Cancer Res 51: 639–643, 1991

    Google Scholar 

  46. Shimoyama Y, Hirohashi S: Cadherin intercellular adhesion molecule in hepatocellular carcinomas: loss of E-cadherin expression in an undifferentiated carcinoma. Cancer letters 57: 131–135, 1991

    Google Scholar 

  47. Schipper JH, Frixen UH, Behrens J, Unger A, Jahnke K, Birchmeier W: E-cadherin expression in squamous cell carcinomas of head and neck: inverse correlation with tumor dedifferentiation and lymph node metastasis. Cancer Res 51: 6328–6337, 1991

    Google Scholar 

  48. Levan G, Szpirer J, Szpirer C, Klinga K, Hanson C, Islam MQ: The gene map of the Norway rat (Rattus Norvegicus) and comparative mapping with Mouse and Man. Genomics 10: 699–718, 1991

    Google Scholar 

  49. Moorselaar van RJA, Ichikawa T, Schaafsma HE, Jap PHK, Isaacs JT, van Stratum P, Ramaekers FCS, Debruyne FMJ, Schalken JAS: The rat bladder tumor model system RBT closely resembles phenotypically and genetically human superficial TCC. Submitted.

  50. Tsuda H, Oda T, Sakamoto M, Hirohashi S: Different pattern of chromosomal allele loss in multiple hepatocellular carcinomas as evidence of their multifocal origin. Cancer Res 52: 1504–1509, 1992

    Google Scholar 

  51. Eistetter HR, Adolph S, Ringwald M, Simon-Chazotte D, Shuh R, Guenet JL, Kemler R: Chromosomal mapping of the structural gene coding for the mouse cell adhesion molecule uvomorulin. Proc Natl Acad Sci USA 85; 10: 3489–3493, 1988

    Google Scholar 

  52. Hatta M, Miyatani S, Copeland NG, Gilbert DJ, Jenkins NA, Takeichi M: Genomic organization and chromosomal mapping of the mouse P-cadherin gene. Nucleic Acids Res 19; 16: 4437–4441, 1991

    Google Scholar 

  53. Scherer G, Bausch E, Gaa A, Deimling von O: Gene mapping on mouse chromosome 8 by interspecific crosses: new data on a linkage group conserved on human chromosome 16q. Genomics 5: 275–282, 1989

    Google Scholar 

  54. Friedlander DR, Mege RM, Cunningham BA, Edelman GM: Cell sorting-out is modulated by both the specificity and amount of different cell adhesion molecules (CAMs) expressed on cell surfaces. Proc Natl Acad Sci USA 86: 7043–7047, 1989

    Google Scholar 

  55. Kintner C: Regulation of embryonic cell adhesion by the cadherin cytoplasmic domain. Cell 69: 225–236, 1992

    Google Scholar 

  56. Sager R: Tumor suppressor genes: the puzzle and the promise. Science 246: 1406–1412, 1989

    Google Scholar 

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  1. Urological Research Laboratory, University Hospital Nijmegen, PO Box 9101, NL-6500 HB, Nijmegen, The Netherlands

    Laurence A. Giroldi & Jack A. Schalken

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  1. Laurence A. Giroldi
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Giroldi, L.A., Schalken, J.A. Decreased expression of the intercellular adhesion molecule E-cadherin in prostate cancer: Biological significance and clinical implications. Cancer Metast Rev 12, 29–37 (1993). https://doi.org/10.1007/BF00689788

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