Conclusions
A new method was developed for the synthesis of substituted hydroxypyrazine derivatives by reacting the hydrochlorides ofα-amino ketones with the acid chlorides of N-phthaloyl-α-amino acids in acetone in the presence of diethylaniline, and subsequent treatment of the intermediate N-(N′-phthaloyl-α′-aminoacyl)-α-amino ketones with aqueous sodium acetate solution at 100°.
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Literature cited
M. Bobec and A. Bloch, J. Med. Chem.,15, 164 (1972).
J. C. MacDonald, R. G. Micetich, and P. H. Haskins, Can. J. Microbiol.,10, 90 (1964).
Y. A. Tota and R. C. Elderfield, J. Org. Chem.,7, 313 (1942).
R. G. Jones, J. Am. Chem. Soc.,71, 78 (1949).
G. Karmas and P. E. Spoerri, J. Am. Chem. Soc.,74, 1580 (1952).
E. E. Smissman, A. Terada, and S. El-Antalby, J. Med. Chem.,19, 165 (1976).
J. P. Greenstein and M. Winitz, Chemistry of the Amino Acids, Wiley (1961).
S. I. Zav'yalov, T. K. Budkova, and M. N. Larionova, Izv. Akad. Nauk SSSR, Ser. Khim.,1976, 1411.
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Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 10, pp. 2417–2421, October, 1978.