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Co-carcinogenic effect of DDT and PCB feedings on methylcholanthrene-induced chemical carcinogenesis

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Summary

Conventional method for assaying the promoting activity of food contaminants on chemical carcinogenesis was presented. Experimental cervical epithelium changes towards cancer were produced by means of 20-methylcholanthrene-impregnated thread inserted into the uterus of female mice which were fed with the diet containing various levels of contaminants. The magnitude of the progress of epithelium changes was compared with animals fed control diet.

Utilizing this procedure it was made obvious that feeding of 100 ppm of DDT for 8 weeks produced a remarkable tendency towards the induction of carcinoma, while 10 ppm of DDT and 10 and 100 ppm of PCB were not effective.

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Authors and Affiliations

  1. Pharmaceutical Institute, Tohoku University, Aobayama, 980, Sendai, Japan

    Mitsuru Uchiyama & Takako Chiba

  2. Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Seiryo-machi, 980, Sendai, Japan

    Kiichiro Noda

Authors
  1. Mitsuru Uchiyama
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  2. Takako Chiba
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  3. Kiichiro Noda
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Uchiyama, M., Chiba, T. & Noda, K. Co-carcinogenic effect of DDT and PCB feedings on methylcholanthrene-induced chemical carcinogenesis. Bull. Environ. Contam. Toxicol. 12, 687–693 (1974). https://doi.org/10.1007/BF01685915

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  • DOI: https://doi.org/10.1007/BF01685915

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