Summary
A rare case of severe primary autoimmune hemolytic anemia with cold agglutinin and extensive cutaneous sclerodermic changes is reported. This association has not been previously documented in the literature. The anemia was refractory to steroids but responded to danazol treatment. Danazol may be an effective therapy in some cases of autoimmune hemolytic anemia with cold agglutinin.
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References
Ahn YS, Harrington JW, Simon SR (1983) Danazol for treatment of idiopathic thrombocytopenic purpura. N Engl J Med 3081:1396–1399
Ahn YS, Harrington JW, Mylvaganam R, Ayub J, Pall LM (1985) Danazol therapy for autoimmune hemolytic anemia. Ann Intern Med 102:298–301
Bartholomew JR, Bell WR, Shirey RS (1987) Cold agglutinin hemolytic anemia: treatment with an environmental suit. Ann Intern Med 106:243–244
Crisp D, Pruzanski W (1982) B cell neoplasms with homogeneous cold reacting antibodies (cold agglutinins). Am J Med 72:915–922
Foersterr J (1993) Autoimmune hemolytic anemia. In: Wintrobe MM (ed) Clinical hematology. Lea & Febiger, Philadelphia, pp 1170–1196
Geffray E, Najman A (1992) Efficacite du danazol dans l'anemie hemolytique autoimmune avec agglutinines froides. Presse Med 21:1472–1475
Gelfand JA, Sherins RJ, Alling DW (1976) Treatment of hereditary angioderma with danazol. N Engl J Med 295:1444–1448
Issitt PD (1978) Autoimmune hemolytic anemia and cold agglutinin disease. Clinical disease and laboratory findings. Prog Clin Pathol 7:137–163
Nydegger VE, Kazatchkine MD, Miescher PA (1991) Immunopathologic and clinical features of hemolytic anemia due to cold agglutinins. Semin Hematol 28:66–77
Polliack A, Lugassy G (1992) Autoimmunity and autoimmune syndromes associated with and preceding the development of lymphoproliferative disorders. Leukemia 6S4:152–154
Rosse WF, Adams JP (1980) The variability of hemolysis in the cold agglutinin syndrome. Blood 54:409–413
Wortman J (1975) Cold agglutinin autoimmune hemolytic anemia in nonhematological malignancies. Am J Hematol 6:275–280
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Lugassy, G., Reitblatt, T., Ducach, A. et al. Severe autoimmune hemolytic anemia with cold agglutinin and sclerodermic features — favorable response to danazol. Ann Hematol 67, 143–144 (1993). https://doi.org/10.1007/BF01701740
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DOI: https://doi.org/10.1007/BF01701740