Skip to main content
SpringerLink
Log in

Genotoxicity assessment of atrazine and some major metabolites in the ames test

  • Published:
Bulletin of Environmental Contamination and Toxicology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  • Adler, ID (1980) A review of the coordinated research effort on the comparison of test systems for the detection of mutagenic effects sponsored by the EEC. Mutation Res 74:77–93

    PubMed  Google Scholar 

  • Ames BN, McCann J, Yamasaki E (1975) Methods for detecting carcinogens and mutagens with theSalmonella/mammalian-microsome mutagenicity test. Mutation Res 31:347–346

    PubMed  Google Scholar 

  • Anderson KJ, Leight DG, Takahashi MT (1972) Evaluation of herbicides for possible mutagenic properties. J Agr Food Chem 20:649–656

    Google Scholar 

  • Anonymous (1983) In: Herbicide Handbook of the Weed Science Society of America, 5th edition. WSSA, Champaign, IL, pp 30–35

  • Anonymous (1987) National pesticide use analyzed. Alternat Agric News 5:1–4

  • Ashton FM, Crafts AS (1981) Mode of Action of Herbicides. John Wiley and Sons, New York, chap 19

    Google Scholar 

  • Benigni R, Bignami M, Camoni I, Carere A, Conti G, Iachetta R, Moapurzo G, Ortali VA (1979) A newin vitro method for testing plant metabolism in mutagenicity studies. J Toxicol Environ Health 5:809–819

    PubMed  Google Scholar 

  • Bertoldi M de, Griselli M, Giovannetti M, Barale R (1980) Mutagenicity of pesticides evaluated by means of gene conversion inSaccharomyces cerevisiae andAspergellus nidulans. Environ Mutag 2:359–370

    Google Scholar 

  • Chou TS, Weber DF (1981) The effect of atrazine on sister-chromatid exchange in maize. Genetics 97:521

    Google Scholar 

  • Dauterman WC and Muecke W (1974)In vitro metabolism of atrazine by rat liver. Pestic Biochem Physiol 4:212–219

    Google Scholar 

  • Esser HO, Dupuis G, Ebert E, Marco GJ, Vogel C (1975)s-Triazines. In: Kearney PC, Kaufman DD (eds) Herbicides: Chemistry, Degradation and Mode of Action, 2nd edition. Marcel Dekker Inc, New York, chap 2

    Google Scholar 

  • Hashimoto Y, Shudo K, Okamoto T, Takahashi Y, Sugimura T (1979) Mutagenicities of 4-hydroxy-1,4-benzoxazinones naturally occurring in maize plants and of related compounds. Mutation Res 66:191–194

    Google Scholar 

  • Hutson DH, Hoadley EC, Griffiths MH, Donninger C (1970) Mercapturic acid formation in the metabolism of 2-chloro-4-ethylamino-6-(1-methyl-1-cyanoethylamino)-s-triazine in the rat. J Agr Food Chem 18:507–512

    Google Scholar 

  • Kappas A (1988) On the mutagenic and recombinogenic activity of certain herbicides inSalmonella typhimurium and inAspergillus nidulans. Mutation Res 204:615–621

    PubMed  Google Scholar 

  • Lamoureux GL Stafford LE, Shimabukuro RH, Zaylskie RG (1973) Atrazine metabolism in sorghum: catabolism of the glutathione conjugate of atrazine. J Agr Food Chem 21:1020–1030

    Google Scholar 

  • Liang GHL, Liang TYS (1972) Effects of atrazine on chromosomal behavior in sorghum. Can J Genet Cytol 14:423–427

    Google Scholar 

  • Lusby DF, Simmons I, McGuire PM (1979) Variation in mutagenecity ofs-triazine compounds tested on fourSalmonella strains. Environ Mutagen 1:287–290

    PubMed  Google Scholar 

  • Means JC, Plewa MJ, Gentile JM (1988) Assessment of the mutagenicity of fractions froms-triazine-testedZea mays. Mutation Res 197:325–336

    PubMed  Google Scholar 

  • Menzie CA (1969) Metabolism of Pesticides. USDI, Bur Sport Fisheries and Wildlife Special Scientific Report — Wildlife No 127. Washington, DC, p 314

  • Muller A, Ebert E, Gast A (1972) Cytogenetic studies with atrazine (2-chloro-4-ethylamino-6-isopropylamino-s-triazine) on plants. Experientia 28:704–705

    PubMed  Google Scholar 

  • Plewa MJ, Gentile JM (1975) A maize-microbe bioassay for detecting proximal mutagenicity in agricultural chemicals. Maize Genet Coop Newslett 49:40–43

    Google Scholar 

  • Plewa MJ, Gentile JM (1976) Mutagenicity of atrazine: A maize-microbe bioassay. Mutation Res 38:287–292

    PubMed  Google Scholar 

  • Sawamura S (1965) Cytological studies on the effect of herbicides in plant cells in vivo, II. Non-hormonic herbicides. Cytologia 30:325–348

    Google Scholar 

  • Shirasu Y, Moriua M, Kato K, Furuhasi A, Kada T (1976) Mutagenicity screening of pesticides in the mocrobial system. Mutation Res 40:19–30

    PubMed  Google Scholar 

  • Siebert D, Lemperle E (1974) Genetic effects of herbicides: induction of mitotic gene conversion inSaccharomyces cerevisiae. Mutation Res 22:111–120

    PubMed  Google Scholar 

  • Sieler JP (1973) A survey on the mutagenecity of various pesticides. Experientia 29:622–623

    PubMed  Google Scholar 

  • Singh I, Lusby AF, McGuire PM (1982) Mutagenicity of HPLC fractions from extracts of AAtrex-treated corn. Environ Mutagenesis 4:45–53

    Google Scholar 

  • Strovev VS (1968) Cytogenetic activity of the herbicides simazine and maleic acid hydrazide. Genetika 6:130–132

    Google Scholar 

  • Strovev VS (1970) Cytogenetic activity of the herbicides atrazine, chloro-IPC, and paraquat. Genetika 6:31–37

    Google Scholar 

  • Sumner DD, Cassidy JE, Szolics IM, Marco GH, Bakshi KS, Brusick DJ (1984) Evaluation of the mutagenic potential of corn (Zea mays L.) grown in untreated and atrazine (AAtrex) treated soil in the field. Drug Chem Toxicol 7:243–257

    PubMed  Google Scholar 

  • Wuu KD, Grant WF (1966) Morphological and somatic chromosomal aberrations induced by pesticides in barley (Hordeum vulgäre). Can J Genet Cytol 8:481–501

    Google Scholar 

  • Wuu KD, Grant WF (1967) Chromosomal aberrations induced by pesticides in meiotic cells of barley. Cytologia 32:31–41

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Southern Weed Science Laboratory, USDA, ARS, 38776, Stoneville, Mississippi, USA

    M. A. Butler & R. E. Hoagland

Authors
  1. M. A. Butler
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. E. Hoagland
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Butler, M.A., Hoagland, R.E. Genotoxicity assessment of atrazine and some major metabolites in the ames test. Bull. Environ. Contam. Toxicol. 43, 797–804 (1989). https://doi.org/10.1007/BF01702047

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01702047

Keywords

Search

Navigation