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Strömungsgeschwindigkeit und Beschleunigung in der Arteria pulmonalis des Hundes

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Zusammenfassung

An 14 Bastardhunden wurde die Strömungsgeschwindigkeit in der A. pulm. mit einer Ultraschallkathetersonde im Kontrollzustand, unter Isuprel- und Propranololwirkung bei elektrischer Stimulation und nach Infusion von Macrodex® gemessen. Im Normalzustand variieren die maximal erreichten Geschwindigkeiten zwischen 32 und 134 cm/sec. Die maximalen Beschleunigungen bewegen sich zwischen 0,8 und 2,8 g. Unter Betastimulation mit Isuprel werden maximale Werte erreicht (v max 156 cm/sec,ý max 3,7 g). Die gemessenen Geschwindigkeitsparameter werden zum Herzzeitvolumen, Schlagvolumen und zur Frequenz in Beziehung gesetzt. Es finden sich signifikante Zuordnungen der maximalen Akzeleration zum HZV (r=0,55) und zum Schlagvolumen (r=0,66), sowie der maximalen Geschwindigkeit zum Schlagvolumes (r=0,77). Auswurfgeschwindigkeit und-beschleunigung sind charakteristische Parameter der auxotonen Kontraktionsphase des Ventrikels. Ihre Kenntnis erlaubt quantitative Rückschlüsse auf die äußere Kraftenwicklung des Myokards. Es wird eine ausführliche Analyse unserer Meßdaten im Hinblick auf die Erfassung der myokardialen Performance gegeben.

Summary

The phasic velocity and acceleration in the pulmonary artery of 14 nembutal anesthetized dogs has been measured by an ultrasound catheter tip velocity flow probe. The method is based on the phase discrimination technique. The velocity parameters are recorded under control conditions, during isoproterenol infusion, after propanolol injection, during single and paired pacing and following macrodex® infusion. Under control conditions the maximal velocities changed individually in a range of 32 to 134 cm/sec, the maximal accelerations varied between 0.8 and 2.2 g. The highest measured values were found during betastimulation with isoproterenol (v max 156 cm/sec,\(\dot v_{max} \) 3.7 g). The relation of the velocity and acceleration parameters to cardiac output, stroke volume and heart rate are analysed. Maximal ejection velocity and its acceleration proved to be a useful parameter in the assessment of ventricular performance. Their determination reveals a more precise understanding of the external developed cardiac force in the course of auxotonic contraction. An analysis of our data from this point of view is presented in this paper.

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Literatur

  1. Bergel, D. H. andW. R. Milnor, Pulmonary vascular impedance in the dog. Circulat. Res.16, 401–415 (1965).

    PubMed  Google Scholar 

  2. Elkins, R. C. andW. R. Milnor, Pulmonary vascular response to exercise in dog. Circulat. Res.29, 591–599 (1971).

    PubMed  Google Scholar 

  3. Fricke, G., U. Studer, andH. Scheu, Pulsatile velocity of blood in the pulmonary artery of dogs. Measurement by an ultrasound gauge. Cardiovasc. Res.4, 371–379 (1970).

    PubMed  Google Scholar 

  4. Fricke, G., H. Scheu, U. Gessner, U. Studer undH. Hirzel, Der Effekt von Isoproterenol auf die Eingangsimpedanz des Pulmonalkreislaufes beim Menschen. Verh. Dtsch. Ges. Kreislaufforschg.37, 284–288 (Darmstadt 1971).

    Google Scholar 

  5. Fricke, G., H. Scheu, unveröffentlichte Untersuchungen.

  6. Gabe, I. T., O. T. Mason, C. J. Mills, J. Gault, J. Ross Jr., E. Braunwald, andJ. P. Shillingford, Application of the catheter tip electromagnetic flowmeter with assessment of cardiac function in man. Circulation38, Suppl., Vol. 6, pp. 80 (1968).

    Google Scholar 

  7. Gabe, I. T., J. H. Gault, J. Ross Jr., D. T. Mason, C. J. Mills, J. P. Shillingford, andE. Braunwald, Measurement of instantaneous blood flow velocity and pressure in conscious map with a cathetertip velocity probe. Circulation40, 603–614 (1969).

    PubMed  Google Scholar 

  8. Holt, J. P., Indicator dilution methods: Indicators, Injection, Sampling and Mixing Problems in Measurement of Ventricular Volume. Amer. J. Cardiol.18, 208–217 (1966).

    Article  PubMed  Google Scholar 

  9. Leonard, E. andS. Hajdu, Action of electrolytes and drugs on the contractile mechanism of the cardiac muscle cell. Handbook of Physiology. Section 2: Circulation, Vol.1, 151–197, Amer. Physiol. Soc. (Washington D. C. 1962).

    Google Scholar 

  10. Lüthy, E., Die Gämodynamik des suffizienten und insuffizienten rechten Herzens. Bibl. Cardiol. Fasc.11 (Basel/New York 1962).

  11. Mills, C. J. andJ. P. Shillingford, A catheter tip electromagnetic velocity probe and its evaluation. Cardiovasc. Res.1, 263–273 (1967).

    Google Scholar 

  12. Milnor, W. R., C. R. Conti, K. B. Lewis, andM. F. O'Rourke, Pulmonary Arterial Pulsé Wave Velocity and Impedance in Man. Circulat. Res.25, No. 6, 637–649 (1969).

    PubMed  Google Scholar 

  13. Patel, D. J. andW. G. Austin, Impedance of certain large blood vessels in Man. Ann. N. Y. Acad. Sci.115, 1129–1139 (1969).

    Google Scholar 

  14. Perroneau, P., J. L. Chevrier, Bui-Mong-Hung, F. Leger, andJ. Hinglais, Blood Flow Velocity Measurement by Ultrasonic Dopple Effect. Velocity Profiles and Velocity. Flow rate relation. European Society for Experimental Surgery, 4th Congress, April 1969.

  15. Pieper, H. P., Catheter tips flowmeter for measurement of pulmonary arterial blood flow in closed chest dogs. Rev. Sci. Instr.34, 908–910 (1963).

    Article  Google Scholar 

  16. Reuben, S. R., J. P. Swadling, andG. de J. Lee, Velocity Profiles in the Main Pulmonary Artery of Dogs and Man, measured with Thin-Film Resistance Anemometer. Circulat. Res.27, 995–1001 (1970).

    Google Scholar 

  17. Rosenblueth, A., J. Alanis, J. López, andE. Rubio, The Adaptation of Ventricular Muscle to Different Circulatory Conditions. Arch. internat. Physiol. Biochim.67, 358–373 (1959).

    Google Scholar 

  18. Sarnoff, S. J., J. H. Mitchell, J. P. Gilmore, andJ. P. Remensnyder, Homeometric autoregulation in the heart. Circulat. Res.8, 1077–1084 (1960).

    PubMed  Google Scholar 

  19. Scheu, H. D., O. Sager undU. Veragut, Eine neue Methode zur intravasalen Messung von Strömungsgeschwindigkeiten. Die Ultraschallsonde. Klin. Wschr.43, 608–611 (1965).

    Article  Google Scholar 

  20. Scheu, H. D., Pulsatile Flow Velocity of the Central Arterial Blood. Bibl. Cardiol. No. 28 (Basel / New York 1972).

  21. Studer, U., G. R. Fricke, andH. D. Scheu, Testing of an improved ultrasound flowmeter: techmical description and results of testing in vitro. Cardiovasc. Res.6, 380–387 (1970).

    Google Scholar 

  22. Williams, J. C. P., T. P. B. O'Donovan, andEarl, H. Wood, A method for the calculation of areas under indictor dilution curves. J. Appl. Physiol.21, 695–699 (1966).

    PubMed  Google Scholar 

  23. Wirz, P., G. Noseda, G. Fricke, H. Simon, M. Turina undW. Rutishauser, Auswirkungen der Frequenzsteigerung auf die Dynamik des linken Ventrikels unter elektrischer Vorhofstimulation und Isuprelinfusion beim Menschen. Verh. Dtsch. Ges. inn. Med.74, 676–679 (München 1968).

    PubMed  Google Scholar 

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Author notes

  1. G. R. Fricke

    Present address: Medizinischen Universitäts-Poliklinik Bonn, Wilhelmstraße 35/37, 5300, Bonn, (Deutschland)

  2. H. D. Scheu

    Present address: , Dufourstraße 108, 8001, Zürich, (Schweiz)

Authors and Affiliations

  1. Medizinischen Universitäts-Poliklinik Bonn, Wilhelmstraße 35/37, 5300, Bonn, (Deutschland)

    H. D. Scheu & H. Simon

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  1. G. R. Fricke
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  2. H. D. Scheu
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  3. H. Simon
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Fricke, G.R., Scheu, H.D. & Simon, H. Strömungsgeschwindigkeit und Beschleunigung in der Arteria pulmonalis des Hundes. Basic Res Cardiol 68, 108–122 (1973). https://doi.org/10.1007/BF01906419

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