Abstract
A sapphire probe and a bare fibre were compared with respect to temperature control and distribution and light fluence in interstitial laser thermotherapy. Experiments were performed in processed liver using an Nd-YAG laser and output power levels of 1–4 W. The temperature was controlled at a distance of 10 mm using a feedback circuit with an automatic thermometry system and thermistor probes. With the sapphire probe, carbonization was rare at power levels of 1–2 W but was observed in half of the experiments at 3 W and in all experiments at 4 W. Using the bare fibre, carbonization was seen in almost all experiments. Absence of carbonization was associated with a moderate decrease in the penetration of light and excellent control of the temperature, whereas carbonization led to rapid impairment of light penetration and temperature control. In addition, the temperature gradient was smaller with the sapphire probe than with the bare fibre or when carbonization was absent. It is concluded that a diffuser tip, such as the sapphire probe, may be preferable to the bare fibre for interstitial laser thermotherapy because it gives a smaller temperature gradient and helps to avoid carbonization which results in preserved light penetration and improved temperature control.
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Mang TS. Combination studies of hyperthermia induced by the Neodymium:Yttrium-Aluminium-Garnet (Nd:YAG) laser as an adjuvant to photodynamic therapy.Lasers Surg Med 1990,10:173–8
Kimel S, Svaasand LO, Hammer-Wilson M et al. Demonstration of synergistic effects of hyperthermia and photodynamic therapy using the chick chorioallantic membrane model.Lasers Surg Med 1992,12:432–40
Wyman DR, Whelan WM, Wilson BC. Interstitial laser photocoagulation: Nd:YAG 1064 nm optical fiber source compared to point heat source.Lasers Surg Med 1992,12:659–64
Amin Z, Buonaccorsi G, Mills T et al. Interstitial laser photocoagulation: evaluation of a 1320 nm Nd-YAG and an 805 nm diode laser: the significance of charring and the value of pre-charring the fibre tip.Lasers Med Sci 1993,8:113–20
Wyman D, Wilson B, Adams K. Dependence of laser photocoagulation on interstitial delivery parameters.Lasers Surg Med 1994,14:59–64
Daikuzono N, Suzuki S, Tajiri H et al. Laserthermia: a new computer-controlled contact Nd:YAG system for interstitial local hyperthermia.Lasers Surg Med 1988,8:254–8
Castrén-Persons M, Lipasti J, Puolakkainen P, Schröder T. Laser-induced hyperthermia: comparison of two different methods.Lasers Surg Med 1992,12:665–8
Masters A, Bown SG. Interstitial laser hyperthermia in tumour therapy.Ann Chir Gynaecol 1990,79:244–51
Möller PH, Lindberg L, Henriksson PH et al. Temperature control and light penetration in a feedback interstitial laser thermotherapy system.Int J Hyperthermia (in press)
Nilsson P. Physics and technique of microwave-induced hyperthermia in the treatment of malignant tumours. PhD Thesis, Lund University, 1984
Svaasand LO, Gomer CJ, Morinelli W. On the physical rationale of laser induced hyperthermia.Lasers Med Sci 1990,5:121–7
Thomsen S. Pathologic analysis of photothermal and photomechanical effects of laser-tissue interactions.Photochem Photobiol 1991,53:825–35
Panjehpour M, Overholt BF, Milligan AJ et al. Nd:YAG laser-induced interstitial hyperthermia using a long frosted contact probe.Lasers Surg Med 1990,10:16–24
Hiele M, Penninckx F, Gevers AM et al. Interstitial thermotherapy for liver tumours: studies of different fibres and radiation characteristics.Lasers Med Sci 1993,8:121–5
Van Hillegersberg R, Vanstaveren HJ, Kort WJ et al. Interstitial Nd:YAG laser coagulation with a cylindrical diffusing fiber tip in experimental liver metastases.Lasers Surg Med 1994,14:124–38
Elias Z, Powers SK, Atstupenas E, Brown JT. Hyperthermia from interstitial laser irradiation in normal rat brain.Lasers Surg Med 1987,7:370–5
Waldow SM, Russell GE, Wallner PE. Microprocessorcontrolled Nd:YAG laser for hyperthermia induction in the RIF-1 tumor.Lasers Surg Med 1992,12:417–24
Godlewski G, Sambuc P, Eledjam JJ et al. A new device for inducing deep localized vaporization in liver with the Nd-YAG laser.Lasers Med Sci 1988,3:111–7
Dowlatshahi K, Bangert JD, Haklin MF et al. Protection of fiber function by para-axial fluid flow in interstitial laser therapy of malignant tumors.Lasers Surg Med 1990,10:322–7
Van Hillegersberg R. Laser treatment for liver metastases: thermal and photodynamic therapy. PhD Thesis, Erasmus University, Rotterdam, 1993
Hahl J, Haapiainen R, Ovaska J et al. Laser-induced hyperthermia in the treatment of liver tumors.Lasers Surg Med 1990,10:319–21
Tsunekawa H, Sugihara M, Kuroiwa A et al. Experimental and clinical studies on laserthermia using an Nd:YAG laser.SPIE 1988,907:66–70
Castrén-Persons M, Schröder T, Rämö OJ et al. Contact Nd:YAG laser potentiates the tumor cell killing effect of hyperthermia.Lasers Surg Med 1991,11:595–600
Waldow SM, Henderson BW, Dougherty TJ. Hyperthermic potentiation of photodynamic therapy employing Photofrin I and II: comparison of results using three animal tumour models.Lasers Surg Med 1987,7:12–22
Levendag PC, Marijnissen JPA, De Ru VJ et al. Interaction of interstitial photodynamic therapy and interstitial hyperthermia in a rat rhabdomyosarcoma—a pilot study.Int J Radiat Oncol Biol Phys 1988,14:139–45
Marijnissen JPA, Star WM. Quantitative light dosimetry in vitro and in vivo.Lasers Med Sci 1987,2:235–4
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Möller, P.H., Lindberg, L., Henriksson, P.H. et al. Interstitial laser thermotherapy: Comparison between bare fibre and sapphire probe. Laser Med Sci 10, 193–200 (1995). https://doi.org/10.1007/BF02133331
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DOI: https://doi.org/10.1007/BF02133331