Skip to main content
Log in

Spironolactone in the treatment of hirsutism

  • Originals
  • Published:
Archives of gynecology Aims and scope Submit manuscript

Summary

Spironolactone was used in 90 hirsute women because of its antiandrogenic effect. The drug was administered twice daily from the 4th to the 22nd day of six cycles (total dosage was 200 mg per day). The results suggest that spironolactone is suitable for the treatment of hirsutism.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Corvol P, Michaud A, Menard J, Freifeld M, Mahoudeau J (1975) Antiandrogenic effects of spironolactones Mechanism of action. Endocrinology 97 52

    Google Scholar 

  2. Cumming DC, Yang JC, Rebar RW, Yen SSC (1982) Treatment of hirsutism with spironolactone. JAMA 247 1295

    Google Scholar 

  3. Eil C, Akelson SK (1984) The use of human skin fibroblasts to obtain potency estimates of drug binding to androgen receptors. J Clin Endocrinol Metab 59 51

    Google Scholar 

  4. Evron S, Shapiro G, Diamant YZ (1981) Induction of ovulation with spironolactone in anovulation oligomenorrheic and hyperandrogenic women. Fertil Steril 36 468

    Google Scholar 

  5. Ferriman D, Gallwey JD (1961) Clinical assessment of body hair growth in women. J Clin Endocrinol Metab 21 1440

    Google Scholar 

  6. Hammerstein J, Meckies J, Leo Rossberg L, Zielske F (1975) Use of cyproterone acetate in the treatment of acne, hirsutism and virilism. J Steroid Biochem 6 827

    Google Scholar 

  7. Horton R, Neisler J (1968) Plasma androgens in patients with polycystic ovarian syndrome. J Clin Endocrinol Metab 28 479

    Google Scholar 

  8. Ismail AA, Davidson DW, Sonka RA (1974) The evaluation of the role of androgens in hirsutism and the use of a new antiandrogen cyproterone acetate for therapy. J Clin Endocrinol 39 81

    Google Scholar 

  9. Kirschner MA, Bardin CW, Hembree WC (1970) Effect of estrogen administration on androgen production and plasma luteinizing hormone in hirsute women. J Clin Endocrinol 30 727

    Google Scholar 

  10. Lobo RA, Shoupe D, Serafini P, Brinton D, Horton R (1985) The effects of two doses of spironolactone on serum androgens and anagen hair in hirsute women. Fertil Steril 43 200

    Google Scholar 

  11. Loriaux DL, Menard R, Taylor A, Pita JC, Santen R (1976) Spironolactone and endocrine dysfunction. Annals of Internal Medicine. 85 630

    Google Scholar 

  12. Lumb G, Newberne P, Rust JH, Wagner B (1978) Effect in animals of chronic administration of spironolactone. A review. In Addison GM, Asmussen NW, Corvol P, Kloppenborg PWC, Norman N, Schröder R, Robertson JIC (eds) Aldosterone antagonists in clinical medicine. Excerpta Medica. Amsterdam Oxford, p 132

    Google Scholar 

  13. Mashesh VB, Grenblatt RB, Aydar CK (1964) Urinary steroid excretion patterns in hirsutism. 1. Use of ovarian and adrenal suppression tests in the study of hirsutism. J. Clin Endocrinol 24 1238

    Google Scholar 

  14. Menard RH, Stripp B, Gilette JR (1974) Spironolactone and testicular cytochrome P-450 Decreased testosterone formation in several species and changes in hepatic drug metabolism. Endocrinology 94 1628

    Google Scholar 

  15. Milewicz A, Silber D, Kirschner MA (1983) Therapeutic effects of spironolactone in polycystic ovary syndrome. Obstet Gynecol 61 429

    Google Scholar 

  16. Ober KP, Hennessy JF (1978) Spironolactone therapy for hirsutism in a hyperandrogenic woman. Ann Intern Med 89 643

    Google Scholar 

  17. Rifka SM, Pita JC, Vigerski RA, Wilson YA, Loriaux DL (1978) Interaction of digitalis and spironolactone with human steroid receptors. J Clin Endocrinol Metab 46 338

    Google Scholar 

  18. Rose LI, Underwood RH, Newmark SR, Kisch ES, Williams GH (1977) Pathophysiology of spironolactone induced gynecomastie. Ann Intern Med 87 398

    Google Scholar 

  19. Shapiro G, Evron S (1980) A novel use of spironolactone Treatment of hirsutism. J Clin Endocrinol Metab 51 429

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Köksal, A., Pabuçcu, R. & Akyürek, C. Spironolactone in the treatment of hirsutism. Arch. Gynecol. 240, 95–100 (1987). https://doi.org/10.1007/BF02134041

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02134041

Keywords

Navigation