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Interactions of the human immunodeficiency virus with astrocytes

  • Part II. HIV Interactions With Neural Cells
  • Published:
Perspectives in Drug Discovery and Design

Summary

Infection with the human immunodeficiency virus type 1 (HIV-1) can cause a dementing illness. Astrocytes, the most numerous cells within the central nervous system, can be infected with HIV-1. These cells are infected by predominantly lymphotropic strains of HIV-1. The mode of infection does not involve CD4 or galactocerebroside C and is, most likely, due to a unique binding-site protein located on the surface of astrocytes. The virus produces low levels of infection. Astrocytic function is significantly altered by viral proteins and nonviral products released by other infected cells. Future therapeutic developments for treating HIV-1 infection will need to take into account the unique mechanisms of interaction of HIV-1 with astrocytes. This review discusses astrocyte involvement in the pathogenesis of the HIV-1 cognitive motor complex.

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Authors and Affiliations

  1. Department of Medical Microbiology, Section of Neurology, University of Manitoba, R3E OW3, Winnipeg, MB, Canada

    Avindra Nath & Christopher Power

  2. Department of Internal Medicine, University of Manitoba, R3E OW3, Winnipeg, MB, Canada

    Avindra Nath & Christopher Power

  3. Department of Pharmacology and Therapeutics, University of Manitoba, R3E OW3, Winnipeg, MB, Canada

    Jonathan D. Geiger

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  1. Avindra Nath
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  2. Christopher Power
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  3. Jonathan D. Geiger
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Nath, A., Power, C. & Geiger, J.D. Interactions of the human immunodeficiency virus with astrocytes. Perspectives in Drug Discovery and Design 5, 30–42 (1996). https://doi.org/10.1007/BF02173999

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  • DOI: https://doi.org/10.1007/BF02173999

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