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HIV-1 infection of a CD4-negative primary cell type: The oligodendrocyte

  • Part II. HIV Interactions With Neural Cells
  • Published:
Perspectives in Drug Discovery and Design

Summary

HIV-1 infection of CD4-negative cells has been described both in vitro and in vivo. Two closely related glycolipids, galactosylceramide (GalCer) and 3′-sulfo-galactosylceramide (GalS), have been proposed as potential alternative cellular receptors for HIV-1. Human adult cultured oligodendrocytes are CD4-negative/GalCer-positive cells that are infected by HIV-1 in vitro, resulting in the presence of stable HIV-1 DNA sequences and the production of virus [Albright et al., Virology, (1996) in press]. The in vivo relevance and the effects of HIV infection on oligodendrocyte biology need to be studied further.

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Abbreviations

PCR:

polymerase chain reaction

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Authors and Affiliations

  1. Graduate Group in Molecular Biology, University of Pennsylvania Medical Center, 19104-6146, Philadelphia, PA, USA

    Andrew V. Albright

  2. Department of Neurology, University of Pennsylvania Medical Center, 19104-6146, Philadelphia, PA, USA

    Andrew V. Albright & Francisco González-Scarano

  3. Department of Pathology, University of Pennsylvania Medical Center, 19104-6146, Philadelphia, PA, USA

    Ehud Lavi

  4. Department of Neurosurgery, University of Pennsylvania Medical Center, 19104-6146, Philadelphia, PA, USA

    Michael O'Connor

  5. Department of Microbiology, University of Pennsylvania Medical Center, 19104-6146, Philadelphia, PA, USA

    Francisco González-Scarano

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  4. Francisco González-Scarano
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Albright, A.V., Lavi, E., O'Connor, M. et al. HIV-1 infection of a CD4-negative primary cell type: The oligodendrocyte. Perspectives in Drug Discovery and Design 5, 43–50 (1996). https://doi.org/10.1007/BF02174000

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  • DOI: https://doi.org/10.1007/BF02174000

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