Summary
HIV-1 is a polytropic virus that, apart from hematopoietic cells, can replicate in several cells from solid tissues. Virus yields vary widely, closely resembling differences in HIV binding to the cells; the latter phenomenon appears mainly related to the extent of CD4 expression, even though other molecules have been implied in virus-cell interactions, the expression of which on the cell membrane can be modulated by several stimuli. During the course of HIV replication, a series of cytokines is produced and released in parallel to virus growth, particularly IL-6 and TNF-α. In fact, exposure of fibroblasts or epithelial cells to these HIV-in-duced cytokines causes an increase of CD4 expression, HIV adsorption to uninfected cells, and release of infectious virions by infected cells. In cells exposed to interferon-γ, IL-6 and TNF-α allow the virus to bypass interferon inhibition of virus release. The fact that HIV-1 adsorption and spread can be mediated by HIV-induced cytokines may be relevant in AIDS pathogenesis, accelerating virus transmission both within the organ and to infiltrating cells, activating a self-maintaining mechanism of infection.
Similar content being viewed by others
References
Fust, G., Dierich, M.P. and Hidvegi, T., Immunol. Today, 16 (1995) 167.
Romagnani, S., Del Prete, G., Manetti, R., Ravina, A., Annunziato, F., De Carli, M., Mazzetti, M., Piccinni, M.P., D'Elios, M.M., Parronchi, P., Sampognaro, S. and Maggi, E., Immunol. Rev., 140 (1994) 73.
Bentwich, Z., Kalinkovich, A. and Weisman, Z., Immunol. Today, 16 (1995) 187.
Levy, J.A., HIV and the Pathogenesis of AIDS, ASM Press, Washington, DC, 1994.
Greene, W.C., New Engl. J. Med., 324 (1991) 308.
Chowdhury, M.I.H., Munataka, T., Koyanagy, Y., Kobayashi, S., Arai, S. and Yamamoto, N., Biochem. Biophys. Res. Commun., 170 (1990) 1365.
Mosca, J.D., Bednarik, D.P., Raj, N.B.K., Rosen, C.A., Sodroski, C.A., Haseltine, W.A. and Pitha, P., Nature, 325 (1987) 67.
Roulston, A., Lin, R., Beauparlant, P., Wainberg, M.A. and Hiscott, J., Microbiol. Rev., 59 (1995) 481.
Vicenzi, E., Turchetto, L., Ruggieri, A. and Poli, G., Semin. Clin. Immunol., 9 (1995) 31.
Dolei, A., Serra, C., Arca, M.V. and Toniolo, A., Aids, 6 (1992) 232.
Plata, F., Garcia-Pons, F., Ryter, A., Lebargy, F., Goodenow, M.M., Dat, M.H.Q., Autran, B. and Mayaud, C., Aids Res. Hum. Retroviruses, 6 (1990) 979.
Tateno, M., Gonzalez-Scarano, F. and Levy, J.A., Proc. Natl. Acad. Sci. USA, 86 (1989) 4287.
Mellert, W., Kleinschmidt, A., Schmidt, J., Festl, H., Emler, S., Roth, W.K. and Erfle, V., Aids, 4 (1990) 527.
Dolei, A., Serra, C., Arca, M.V., Tilocca, F., Riva, E., Antonelli, G., Dianzani, F. and Toniolo, A., Aids Res. Hum. Retroviruses, 10 (1994) 1089.
Nelson, J.A., Wiley, C.A., Reynolds-Kohler, C., Reese, C.E., Margaretten, W. and Levy, J.A., Lancet 1, (1988) 259.
Yahi, N., Baghdiguian, S., Bolmont, C. and Fantini, J., J. Acquired Immune Defic. Syndr., 5 (1992) 993.
Toniolo, A., Serra, C., Conaldi, C., Basolo, F., Falcone, V. and Dolei, A., Aids, 9 (1995) 859.
Nottet, H.S.L.M., Janse, I., De Graaf, L., Bakker, L.J., Visser, M.R. and Verhoef, J., J. Med. Virol., 40 (1993) 39.
Barboza, A., Castro, B.A., Whalen, M., Moore, C.C.D., Parkin, J.S., Miller, W.L., Gonzalez-Scarano, F. and Levy, J.A., Aids, 6 (1992) 1437.
Cao, Y., Friedman-Kien, A.E., Huang, Y., Li, X.L., Mirabile, M., Moudgil, T., Zucker-Franklin, D. and Ho, D.D., J. Virol., 64 (1990) 2553.
Clapham, P.R., Weber, J.N., Whitby, D., McIntosh, K., Dalgleish, A.G., Maddon, P.J., Deen, K.C., Sweet, R.W. and Weiss, R.A., Nature, 337 (1989) 368.
Li, X.L., Moudgil, T., Vinters, H.V. and Ho, D.D., J. Virol., 64 (1990) 1383.
Ensoli, F., Cafaro, A., Fiorelli, V., Vannelli, B., Ensoli, B. and Thiele, C., Virology, 210 (1995) 221.
Re, M.C., Furlini, G., Cenacchi, G., Preda, P. and La Placa, M., Microbiologica, 14 (1991) 149.
Steffan, A.M., Lafon, M.E., Gendrault, J.L., Schweitzer, C., Royer, C., Jaeck, D., Arnaud, J.P., Schmitt, M.P., Aubertin, A.M. and Kirn, A., Proc. Natl. Acad. Sci. USA, 89 (1992) 1582.
Scheglovitova, O., Capobianchi, M.R., Antonelli, G., Guamnu, D. and Dianzani, F., Arch. Virol., 132 (1993) 267.
Conaldi, P.G., Serra, C., Dolei, A., Basolo, F., Falcone, V., Mariani, G., Speziale, P. and Toniolo, A., J. Med. Virol., 47 (1995) 355.
Poland, S.D., Rice, G.P.A. and Debakan, G.A., J. Acquired Immune Defic. Syndr., 8 (1995) 437.
Fazely, F., Fry, G.N., Thirkill, T.L., Hakim, H., King, B.F. and Douglas, G.C., Aids Res. Hum. Retroviruses, 11 (1995) 1023.
Lewis, S.H., Reynolds-Koheler, C., Fox, H.E. and Nelson, J.A., Lancet, 335 (1990) 565.
Zachar, V., Norskov-Lauritsen, N., Juhl, C., Spire, B., Chermann, J.C. and Ebbesen, P., J. Gen. Virol., 72 (1991) 1253.
da Silva, M., Shevchuck, M.M., Cronin, W.J., Armenakas, N.A., Tannenbaum, M., Fracchia, J.A. and Ioachim, H.L., Am. J. Clin. Pathol., 93 (1989) 196.
Scofield, V.L., Rao, B., Broder, S., Kennedy, C., Wallace, M., Graham, B. and Poiesz, B.J., Aids, 8 (1994) 1733.
Cohen, A.H., Sun, N.C.J., Shapshak, P. and Imagawa, D.T., Mod. Pathol., 2 (1989) 125.
Roederer, M., Staal, F.J., Raju, P.A., Ela, S.W. and Herzenberg, L.A., Proc. Natl. Acad. Sci. USA, 87 (1990) 4884.
Green, D.F., Resnick, L. and Bourgoignie, J.J., Kidney Int., 41 (1992) 956.
Lipshultz, S.E., Fox, C.H., Perez-Atayde, A.R., Sanders, S.P., Colan, S.D., McIntosh, K. and Winter, H.S., Am. J. Cardiol., 66 (1990) 246.
Espinoza, L., Aguilar, J.L., Espinoza, C.G., Berman, A., Gutierrez, F., Vasey, F.B. and Germain, B.F., J. Rheumatol., 17 (1990) 1195.
Chesebro, B. and Wehrly, K., J. Virol., 62 (1988) 3779.
Yahi, N., Baghdiguian, S., Moreau, H. and Fantini, J., J. Virol., 66 (1992) 4848.
Callebaut, C., Krust, B., Jacotot, E. and Hovanessian, A.G., Science, 262 (1993) 2045.
Oravecz, T., Roderiquez, G., Koffi, J., Wang, J., Ditto, M., Chequer Bou-Habib, D., Lusso, P. and Norcross, M.A., Nature Med., 1 (1995) 919.
Arthur, L.A., Bess, J.W., Sowder, R.C., Benveniste, R.E., Mann, D.L., Chermann, J.C. and Henderson, L.E., Science, 258 (1992) 1935.
Capobianchi, M.R., Serra, C., Abbate, I., Marongiu, P., Castilletti, C., Tilocca, F., Dianzani, F. and Dolei, A., Aids, 8 (1994) 1731.
Vitkovic, L., Wood, G.P., Major, E.O. and Fauci, A.S., Aids Res. Hum. Retroviruses, 7 (1991) 723.
Merrill, J.E., Koyanagi, Y., Zack, J., Thomas, L., Martin, F. and Chen, I.S.Y., J. Virol., 66 (1992) 2217.
Tornatore, C., Nath, A., Amemya, K. and Major, E., J. Virol., 65 (1991) 6094.
Ameglio, F., Tilocca, F., Arca, M.V., Alemanno, L. and Dolei, A., Aids Res. Hum. Retroviruses, 9 (1993) 795.
Dolei, A., Arca, M.V., Tilocca, F., Pietravalle, M., Alemanno, L., Toniolo, A. and Ameglio, F., Arch. Virol., 134 (1994) 157.
Basolo, F., Serra, C., Ciardiello, F., Russo, J., Campani, A., Dolei, A., Squartini, F. and Toniolo, A., Int. J. Cancer, 51 (1992) 634.
Rosenberg, Z.F. and Fauci, A.S., Immunol. Today, 11 (1990) 176.
Dolei, A., Serra, C., Arca, M.V. and Toniolo, A., J. Res., 10 (1990) S107.
Dolei, A., Serra, C., Tilocca, F., Marongiu, P., Curreli, S., Modesti, A., Toniolo, A. and Ameglio, F., J. Interferon Res., 14 (1994) S200.
Ameglio, F., Tosi, R., Tanigaki, N. and Dolei, A., In Solheim, B.G., Moller, E. and Ferrone, S. (Eds.) HLA class II Antigens, Springer, Berlin, 1985, pp. 299–313.
Buonaguro, L., Barillari, G., Chang, H.K., Bohan, C.A., Kao, V., Morgan, R., Gallo, R.C. and Ensoli, B., J. Virol., 66 (1992) 7159.
Serra, C., Marongiu, P., Biolchini, A., Curreli, S., Ameglio, F. and Dolei, A., J. Interferon Cytokine Res., 15 (1995) S187.
Barillari, G., Buonaguro, L., Fiorelli, V., Hoffman, J., Michaels, F., Gallo, R.C. and Ensoli, B., J. Immunol., 149 (1992) 3727.
Bhat, S., Spitalnik, S.L., Gonzalez-Scarano, F. and Silberberg, D.H., Proc. Natl. Acad. Sci. USA, 88 (1991) 7131.
Ikeuchi, K., Kim, S., Byrn, R.A., Goldring, S.R. and Groopman, J.E., J. Virol., 64 (1990) 4226.
Poli, G.A., Kinter, L. and Fauci, A.S., Proc. Natl. Acad. Sci. USA, 91 (1994) 108.
Matsuyama, T., Kobayashi, N. and Yamamoto, N., Aids, 5 (1991) 1405.
Schuitemaker, H., Kootstra, N.A., Koppelman, M.H., Bruisten, S.M., Huisman, H.G., Tersmette, M. and Miedema, F., J. Clin. Invest., 89 (1992) 1154.
Osborn, L., Kunkel, S. and Nabel, G.J., Proc. Natl. Acad. Sci. USA, 86 (1989) 2336.
Folks, T.M., Justement, J.S., Kinter, A., Dinarello, C.A. and Fauci, A.S., Science, 238 (1987) 800.
Novak, R.M., Holzer, T.J., Kennedy, M.M., Heynen, C.A. and Dawson, G., Aids Res. Hum. Retroviruses, 6 (1990) 973.
Dolei, A., Fattorossi, A., D'Amelio, R., Aiuti, F. and Dianzani, F., J. Interferon Res., 6 (1986) 543.
Castilletti, C., Capobianchi, M.R., Gentile, M., Abbate, I., Barresi, C., Fais, S., Gelderblom, H. and Dianzani, F., J. Interferon Cytokine Res., 15 (1995) S192.
Poli, G., Kinter, A.L., Justement, J.S., Bressler, P., Kehrl, J.H. and Fauci, A.S., J. Exp. Med., 173 (1991) 589.
Pitha, P.M., J. Interferon Res., 11 (1991) 313.
Kootstra, N.A., Van 't Wout, A.B., Huisman, H.G., Miedema, F. and Schuitemaker, H., J. Virol., 68 (1994) 6967.
Montaner, L.J., Doyle, A.G., Collin, M., Herbein, G., Illei, P., James, W., Minty, A., Caput, D., Ferrara, P. and Gordon, S., J. Exp. Med., 178 (1993) 743.
Mackewicz, C.E., Ortega, H. and Levy, J.A., J. Clin. Invest., 87 (1994) 1462.
Note added in proof: after submission of this paper, four chemokines produced by CD8+ lymphocytes have been found to inhibit HIV: RANTES, MIP-1α and MIP-1β [Cocchi, F., De Vico, A.L., Garzino-Demo, A. Arya, S.K. Gallo, R.C. and Lusso, P., Science, 270 (1995) 1811] and IL-16 [Bayer, M., Werner, A., Bannert, N., Metzner, K. and Kurth, R., Nature, 378 (1995) 563].
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Dolei, A., Serra, C., Biolchini, A. et al. HIV-permissive cells from solid tissues: Cytokine induction and effects. Perspectives in Drug Discovery and Design 5, 93–102 (1996). https://doi.org/10.1007/BF02174005
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02174005