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Interaction of human immunodeficiency virus type 1 envelope protein with liposomes containing galactosylceramide

  • Part VI. Galactosylceramide (GalCer) As The Prototype Of A New Family Of HIV Receptors
  • Published:
Perspectives in Drug Discovery and Design

Summary

The glycosphingolipid galactosylceramide (GalCer) has been identified as an alternate receptor for the human immunodeficiency virus type 1 (HIV-1). Here we review a liposome flotation assay used to study the interaction of the HIV-1 envelope glycoprotein (env) with artificial membrane vesicles containing GalCer. The properties of binding, the nature of the env binding site for GalCer, and the implications of this interaction for HIV-1 infection are discussed.

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  1. Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 19104-6100, Philadelphia, PA, USA

    Joanne F. Berson, Robert W. Doms & Deborah Long

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Berson, J.F., Doms, R.W. & Long, D. Interaction of human immunodeficiency virus type 1 envelope protein with liposomes containing galactosylceramide. Perspectives in Drug Discovery and Design 5, 169–180 (1996). https://doi.org/10.1007/BF02174012

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  • DOI: https://doi.org/10.1007/BF02174012

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