Abstract
The effects of daily supplemental chromium (200 μg) complexed with 1.8 mg nicotinic acid on plasma glucose and lipids, including total cholesterol, HDL cholesterol, LDL cholesterol, and triglycerides, were assessed in 14 healthy adults and 5 adults with noninsulin-dependent diabetes mellitus (NIDDM) using a double-blind crossover study with 8-wk experimental periods. Eight of the 14 healthy subjects and all 5 subjects with NIDDM also underwent an oral glucose tolerance test with assessment of 90 min postprandial plasma glucose and insulin concentrations. No statistically significant effects of chromium nicotinic acid supplementation were found on plasma insulin, glucose, or lipid concentrations, although chromium nicotinic acid supplementation slightly lowered fasting plasma total and LDL cholesterol, triglycerides, and glucose concentrations, and 90-min postprandial glucose concentrations in individuals with NIDDM.
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References
L. F. Berrio, L. L. Southern, J. M. Fernandez, D. L. Thompson, and T. L. Ward, Effect of dietary chromium tripicolinate on insulin binding in isolated pig fat cells and erythrocyte ghosts,FASEB J. 9, A449 (1995).
J. F. Potter, P. Levin, R. A. Anderson, J. M. Freiberg, R. Andres, and D. Elahi, Glucose metabolism in glucose-intolerant older people during chromium supplementation,Metabolism 34, 199–204 (1985).
W. Mertz, Chromium in human nutrition: A review,J Nutr. 123, 626–633 (1993).
M. Urberg and M. R. Zemel, Evidence for synergism between chromium and nicotinic acid in the control of glucose tolerance in elderly humans,Metabolism 36, 896–899 (1987).
A. S. Abraham, B. A. Brooks, and U. Eylath, The effects of chromium supplementation on serum glucose and lipids in patients with and without non-insulin dependent diabetes,Metabolism 41, 768–771 (1992).
R. Riales and M. J. Albrink, Effect of chromium chloride supplementation on glucose tolerance and serum lipids including high density lipoprotein of adult men,Am J Clin Nutr. 34, 2670–2678 (1981).
R. T. Mossop, Effects of chromium (III) on fasting glucose, cholesterol and cholesterol HDL levels in diabetics,Cent. Afr. J. Med. 29, 80–82 (1983).
M. M. Wang, E. A. Fox, B. J. Stoecker, C. E. Menendez, and S. B. Chan, Serum cholesterol of adults supplemented with brewer's yeast or chromium chloride,Nutr. Res. 9, 989–998 (1989).
R. A. Anderson, M. M. Polansky, N. A. Bryden, and J. J. Canary, Supplemental-chromium effects on glucose, insulin, glucagon, and urinary chromium losses in subjects consuming controlled low-chromium diets,Am. J. Clin. Nutr. 54, 909–916 (1991).
R. A. Anderson, M. M. Polansky, N. A. Bryden, E. E. Roginski, W. Mertz, and W. Glinsmann, Chromium supplementation of human subjects: Effects on glucose, insulin and lipid variables,Metabolism Clin. Exp. 32, 894–899 (1983).
E. G. Offenbacher, C. J. Rinko, and F. X. Pi-Sunyer, The effects of inorganic chromium and brewer's yeast on glucose tolerance, plasma lipids, and plasma chromium in elderly subjects,Am. J. Clin. Nutr. 42, 454–461 (1985).
M. I. J. Uusitupa, J. T. Kumpulainen, E. Voutilainen, K. Hersio, H. Sarlund, K. P. Pyorala, P. E. Koivistoinen, and J. T. Lehto, Effect of inorganic chromium supplementation on glucose tolerance, insulin response, and serum lipids in non-insulin dependent diabetics,Am. J. Clin. Nutr. 38, 404–410 (1983).
W. Mertz, E. W. Toepfer, E. E. Roginski, and M. M. Polansky, Present knowledge of the role of chromium,Fed. Proc. 33, 2275–2280 (1974).
J. C. Yang, G. Z. Dai, J. Y. Guo, B. Z. Yan, S. Q. Chen, S. Y. Cai, and Z. R. Cao, The synthesis, animal experiments, and preliminary clinical trial of chromium (III)-nicotinic acid-amino acids mixed ligand complexes,Huaxi Yike Daxue Xuebao 19, 167–169 (1988).
R. A. Anderson, Recent advances in the clinical and biochemical effects of chromium deficiency inEssential and Toxic Trace Elements in Human Health and Disease: An Update, Wiley-Liss, New York, pp. 221–234 (1993).
W. T. Friedewald, R. I. Levy, and D. S. Fredrickson, Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge,Clin. Chem. 18, 499–502 (1972).
R. A. Anderson and A. S. Kozlovsky, Chromium intake, absorption and excretion of subjects consuming self-selected diets.Am. J. Clin. Nutr. 41, 1177–1183 (1985).
R. A. Anderson, Chromium, glucose tolerance, and diabetes.Biol. Trace Element Res. 32, 19–24 (1992).
H. J. Dowling, E. G. Offenbacher, and F. X. Pi-Sunyer, Effects of amino acids on the absorption of trivalent chromium and its retention by regions of the rat small intestine.Nutr. Res. 10, 1261–1271 (1990).
W. Mertz, Effects and metabolism of glucose tolerance factor.Nutr. Rev. 33, 129–135 (1975).
R. A. Anderson, N. A. Bryden, and M. M. Polansky, Form of chromium effects tissue chromium concentrations,FASEB J. 7, A204 (1993).
M. F. McCarty, The case for supplemental chromium and a survey of clinical studies with chromium picolinate,J. Appl. Nutr. 43, 58–66 (1991).
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Thomas, V.L.K., Gropper, S.S. Effect of chromium nicotinic acid supplementation on selected cardiovascular disease risk factors. Biol Trace Elem Res 55, 297–305 (1996). https://doi.org/10.1007/BF02785287
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DOI: https://doi.org/10.1007/BF02785287