Abstract
Calcium plays an important role in the pathophysiology of essential hypertension. Serum calcium levels were measured in 117 subjects with essential hypertension and 77 first-degree relatives. The results showed that serum calcium levels were significantly (p<0.01) decreased in both males and females with essential hypertension and their first-degree relatives when compared with the normotensive controls. This is the first study in Indian population.
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Leonard, D., McDermott, R., Odea, K., Rowley, K.G., Pensio, P., Sambo, E., Twist, A., Toolis, R., Lowson, S. and Best, JD. (2002). Aust N Z J Public Health 26, 144–149.
Borghi, L., Meschi, T., Guerra, A., Briganti, A., Schianchi, T., Allegri, F. and Novarini A. (1999). Essential arterial hypertension and stone disease. Kidney Int. 55, 2397–2406.
Zidek, W., Vetter, H., Dorst, K.G., Zumkley, H. and Loose, H. (1982). Intracellular Na+ and Ca2+ activities in essential hypertension. Clinical Science. 63, 41S-43S.
Touyz, R.M., and Milne, F.J. (1995). Alterations in intracellular cations and cell membrane ATPase activity in patients with malignant hypertension. J. Hypertens., 13, 867–874.
Fu, Y., Wang, S., Lu, Z., Li, H. and Li, S. (1998). Erythrocyte and plasma Ca2+, Mg2+ and cell membrane adenosine triphosphatase activity in patients with essential hypertension. Clin. Med. J. (Engl) 111, 147–149.
Touyz, R.M., Milne, F.J. and Reinach S.G. (1992). Intracellular Mg2+, Ca2+, Na2+ and K+ in platelets and erythrocytes of essential hypertension patients: relation to blood pressure. J. Hypertens., 14, 1189–1209.
Zettner A. Seligson (1964). Application of atomic absorption spectrophotometry in the determination of calcium in serum. Clin. Chem. 10, 869–889.
Touyz, R.M., Milne, F.J. Seftel. H.C. and Reinach, S.G. (1987). Magnesium, calcium, sodium and potassium status in normotensive and hypertensive Johannesburg residents. S. Afr. Med. J. 72, 377–381.
Reichel, H., Liebethal, R., Hense, H.W., Schmidt, G.H., and Ritz, E. (1992). Disturbed calcium metabolism in subjects with elevated diastolic blood pressure. Clin. Investig. 70, 748–751.
Kosch, M., Hausberg, M., Barembrock, M., Posadzy-malaczynska, A., Rahn, KH, Kisters, K. (2001). Increased membranous calcium concentrations in primary hypertension: a causal link to pathogenesis. J. Hum. Hypertens., 15, 37–40.
Haenni, A., Reneland, R., Lind, L. and Lithell, H. (2001). Serum aldosterone changes during hyperinsulinemia are correlated to body mass index and insulin sensitivity in patients with essential hypertension. J. Hypertens., 19, 107–112.
Holloway, E.T., and Bohr, D.F. (1973). Reactivity of vascular smooth muscle in hypertensive rats. Circ. Res. 33, 678–685.
Resnick, L.M. (1990). The effects of sodium and calcium in clinical hypertension: mediating role of vitamin D metabolism. Adv. Second Messenger Phosphoprotein Res. 24, 535–541.
Chlumsky, J. (1993). Calcium and hypertension. J. Hypertens. 39, 1181–1184.
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Sudhakar, K., Sujatha, M., Babu, S.R. et al. Serum calcium levels in patients with essential hypertension and their first degree relatives. Indian J Clin Biochem 19, 21–23 (2004). https://doi.org/10.1007/BF02872383
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DOI: https://doi.org/10.1007/BF02872383