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Effect of the saponin fraction ofPanax ginseng on catecholamines in mouse brain

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Abstract

The amount of norepinephrine and dopamine in the brain of the mouse fed with normal diet or protein deficient diet with supplement of the saponin fraction of ginseng were determined by the fluorometric method. The amount of norepinephrine in mouse brain was increased by supplement of the saponin fraction of ginseng throughout the experimental period regardless of the kind of diet. However, the enhancing effect of the saponin fraction of ginseng on the level of norepinephrine in mouse brain was vivider in the case of protein deficiency. The increase amount of dopamine was observed only in the case of mouse fed with normal diet with supplement of the saponin fraction of ginseng for 8 weeks.

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Literature Cited

  1. Korean Ginseng Research Institute, Republic of Korea:Pharmacological actions of ginseng. pp. 46 (1978).

  2. Takagi, K., Saito, H. and Nabata, H.: Pharmacological studies of Panax ginseng root.Japan J. Pharmacol. 22, 245 (1972).

    Article  CAS  Google Scholar 

  3. Saito, H., Yoshida, Y., and Takagi, K.: Effect of Panax ginseng root on exhaustive in mice.Japan J. Pharmacol. 24, 119 (1974).

    Article  CAS  Google Scholar 

  4. Takagi, K., Saito, H., and Tsuchiya, M.: Pharmacological properties of a crude saponin fraction.Japan J. Pharmacol. 22, 239 (1972).

    Google Scholar 

  5. Nabata, H., Saito, H. and Takagi, K.: Pharma cological studies of neutral saponin of Panax ginseng root.Japan J. Pharmacol. 23, 29 (1973).

    CAS  Google Scholar 

  6. Brekhman, I.I., and Dardymov, I.V.: New substance of plant origin which increase nonspecific resistance.Ann. Rev. Pharm. 9, 419 (1969).

    Article  CAS  Google Scholar 

  7. Saito, H., Suda, K., Schwab, M. and Thoeneu, H.: Potentiation of the NGF-Mediated nerve fiber outgrowth by ginsenoside Rb1 in organ cultures of chicken dorsal root ganglia.Japan J. Pharmacol. 27, 445–451 (1977).

    Article  CAS  Google Scholar 

  8. Kim, Y. and Kim, E.: Studies on the effect of ginseng extract on chicken embryonic nerve and muscle cells.Yakhak Hoeji. 24, 143–150 (1980).

    CAS  Google Scholar 

  9. Cooper, J.R., Bloom, F.E. and Roth, R.H.:The Biological Basis of Neuropharmacology pp. 102–195 Oxford University Press (1978).

  10. Shoemaker, W.J. and Wurtman, R.J.: Effect of prenatal undernutrition on the metabolism of catecholamines in the rat brain.J. Nutr. 103, 1537 (1973).

    PubMed  CAS  Google Scholar 

  11. Ahmad, Gulzar and Rahman, M.A.: Effect of undernutrition and protein malnutrition on brain chemistry of rats.J. Nutr. 105, 1090–1103 (1975).

    PubMed  CAS  Google Scholar 

  12. Wurtman, R.J. and Fernstom, J.D.: Effect of the diet on brain neurotransmitters.Nutr. Rev. 32, 193 (1074).

    Article  Google Scholar 

  13. Shoemaker, W.J. and Wurtman, R.J.: Prenatal undernutrition; Accumulation of catecholamines in rat brain.Science 171, 1017–1019 (1971).

    Article  PubMed  CAS  Google Scholar 

  14. Hrubes, V. and Benes, V.: Time course of metabolic changes during prolonged stress in rats.J. Psychosom Res. 13, 327 (1969).

    Article  PubMed  CAS  Google Scholar 

  15. Namba, T., Yoshizaki, M., Tomimori, T., Kobashi, K., Mitaui, K. and Hase, J.: Fundamental studies on the evaluation of the crude drugs. III Chemical and biochemical evaluation of ginseng and related crude drugs.Yakugaku Zasshi. 94, 252 (1974).

    PubMed  CAS  Google Scholar 

  16. Ansell, G.B. and Beeson, M.F.: A rapid and sensitive procedure for the combined assay of adrenaline, dopamine and serotonin in a single brain sample.Anal. Biochem. 23, 196 (1968).

    Article  PubMed  CAS  Google Scholar 

  17. Shellenberger, M.K. and Gordon, J.H.: A rapid, simplified procedure for simultaneous assay of norepinephrine, dopamine, and serotonin from discrete brain areas.Anal. Biochem. 39, 350 (1971).

    Article  Google Scholar 

  18. Martin, I.L. and Ansell, G.B.: Estimation of noradrenaline, dopamine and 5-hydroxytryptamine in rat brain.Biochem. Pharm. 22, 521 (1973).

    Article  PubMed  CAS  Google Scholar 

  19. Sereni, F., Principi, N., Perletti, L. and Sereni, L.P.: Undernutrition and the developing rat brain.Biol. Neonat. 10, 254 (1966).

    PubMed  CAS  Google Scholar 

  20. Dobbing, J.: The effect of undernutrition on myelination in the central nervous system.Biol. Neonat. 9, 132 (1966).

    CAS  Google Scholar 

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Kim, Y.C., Lee, J.H., Kim, M.S. et al. Effect of the saponin fraction ofPanax ginseng on catecholamines in mouse brain. Arch. Pharm. Res. 8, 45–48 (1985). https://doi.org/10.1007/BF02897566

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  • DOI: https://doi.org/10.1007/BF02897566

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