Abstract
Ethanolic extract ofDaucus carota (DC) at the dose of 10–100 mg/kg caused a dose-dependent fall in systolic and diastolic arterial, blood pressure in normotensive anesthetized rats. These effects were not blocked by atropine (1 mg/kg) and pretreatment withDC did not alter the pressor response to norepinephrine indicating that, cardiovascular effects ofDC are independent of cholinergic or adrenergic receptors involvement. In spontaneously beating guinea-pig paired atria,DC induced a, concentration-dependent (0.3–5 mg/ml) decrease in force and rate of atrial contractions. In rabbit thoracic aorta,DC caused inhibition of K+-induced contractions at similar concentrations. These results suggest that the extract may exhibit Ca2+ channel blocking-like direct relaxant action on cardiac and smooth muscle preparations and this action may be responsible for its hypotensive effect observed in thein vivo studies.
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References Cited
Agarwal, S. L., Dandiya, P. C. and Sharma, V. N., Chemical and pharmacological investigations of seeds ofDacus carota.Indian Pharmacist, 8, 291–296 (1953).
Arunlakshana, O. and Schild, H. O., Some quantitative uses of drug antagonists.Brit. J. Pharmacol. Chemother., 14, 48–58 (1959).
Bolton T. B., Mechanism and action transmitters and others substances on smooth muscles.Physiol. Rev., 59, 606–718 (1979).
Brown, J., Doxey, J. C. and Handley, S., Effects of alpha adrenoceptor agonists and antagonists and of antideppressant drugs on pre and postsynaptic alphaad-renoceptors.Eur. J. Pharmac., 67, 33–40 (1980).
Duke, J. A.,Handbook of phytochemical constitutents of Grass herbs and other economic plants, CRC Press, London, 1992, pp. 224–229.
Gilani, S. A. H. and Cobbin, L. B., Cardio-selectivity of himbacine: a muscarine receptor antagonist.Naunyn-Schmiedeberg’s Arch. Pharmacol., 332, 16–20 (1986).
Gilani, S. A. H. and Cobbin, L. B., The interaction of himbacine with carbachol at muscarinic receptors in heart and smooth muscle.Arch Int. Pharmacodyn., 290, 46–53 (1987).
Gilani, A. H., Comparison of anticholinergic actions of gallamine and himbacine.Rev. Farmacal. Clin. Exp., 6, 23–27 (1989).
Gilani, A. H., Hypotensive activity of himbacine in anesthetized cats.Drug Development Res., 24, 127–133 (1991).
Godfraind, T., Miller, R. and Wibo, M., Calcium antagonism and calcium entry blockade.Pharmacological Rev., 38, 321–416 (1984).
Hoffman, B. B. and Lefkowitz, R. J., Catecholamines and sympathomimetic drugs, In: A. D. Gilman, L. S. Goodman, T. W. Rall and F. Murad (Eds.),The Pharmacological basis of therapeutics, 8th edn, Pergmon Press, New York, 1990a, pp. 187–220.
Hoffman, B. B. and Lefkowitz, R. J., Adrenergic receptor antagonists, In: A. D. Gilman, L. S. Goodman, T. W. Rall and F. Murad (Eds)The Pharmacological basis of therapeutics, 8th edn, Pergamon Press, New York, 1990b, pp. 221–243.
Kaliwal, B. B., Ahmed, R. N., anel Rao, M. A., Abortifacient effect of carrot seed (Daucus carota) extract and its reversal by progresterone in albino rats:Canad.Physiol. Ecol., 9, 70–74 (1984).
Karaki, H. and Weiss, G., Mini-review: calcium release in smooth muscles.Life Sci., 42, 111–122 (1988).
Murray, J. A., Plants drugs of Sind; Indus Publication, Karachi, Pakistan 1989, p. 31.
Nadkami, A. K.,Indian Materia, Medica. Popular Prakashan, Bombay, 1976, pp. 440–442.
Said, H. M.,Hamdard Pharmacopoea of Eastern Medicine. Hamdard Foundation Press, Karachi, 1972, p. 52.
Van Rossum, J. M., Cumulative dose-response curves II: Techniques for the making of dose-response curves in isolated organs and the evaluation of drug parameters.Arch. Int. Pharmacodyn., 143, 299–320 (1963).
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Gilani, A.H., Shaheen, F. & Saeed, S.A. Cardiovascular actions ofDaucus carota . Arch. Pharm. Res. 17, 150–153 (1994). https://doi.org/10.1007/BF02974250
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DOI: https://doi.org/10.1007/BF02974250