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Frailty, osteoporosis and hip fracture: Causes, consequences and therapeutic perspectives

  • Published:
The Journal of Nutrition Health and Aging

Abstract

Objective: The aim of this review of the literature is to report the factors which both contribute to the frailty syndrome and increase hip fracture risk in the elderly. This work is the fruit of common reflection by geriatricians, endocrinologists, gynecologists and rheumatologists, and seeks to stress the importance of detection and management of the various components of frailty in elderly subjects who are followed and treated for osteoporosis. It also sets out to heighten awareness of the need for management of osteoporosis in the frail elderly.Design: The current literature on frailty and its links with hip fracture was reviewed and discussed by the group.Results: The factors and mechanisms which are common to both osteoporosis and frailty (falls, weight loss, sarcopenia, low physical activity, cognitive decline, depression, hormones such as testosterone, estrogens, insulin-like growth factor-I (IGF-I), growth hormone (GH), vitamin D and pro-inflammatory cytokines) were identified. The obstacles to access to diagnosis and treatment of osteoporosis in the frail elderly population and common therapeutic pathways for osteoporosis and frailty were discussed.Conclusion: Future research including frail subjects would improve our understanding of how management of frailty can can contribute to lower the incidence of fractures. In parallel, more systematic management of osteoporosis should reduce the risk of becoming frail in the elderly population.

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Authors and Affiliations

  1. Inserm U558, F-31073

    Y. Rolland, G. Abellan van Kan, F. Nourhashemi & B. Vellas

  2. Université de Toulouse III, F-31073, Toulouse

    Y. Rolland, G. Abellan van Kan, F. Nourhashemi & B. Vellas

  3. Gerontopôle de Toulouse, F-31059

    Y. Rolland, G. Abellan van Kan, F. Nourhashemi & B. Vellas

  4. Centre de Gériatrie, CHU de Nancy, 1 INSERM Unité U684, Université de Nancy, France

    A. Benetos

  5. Pôle de Gérontologie, Centre de Prévention et de Traitement des Maladies du Vieillissement, CHU Montpellier, 39, avenue Charles Flahault, 34295, Montpellier Cedex 5

    H. Blain & C. Jeandel

  6. Service de Médecine Gériatrique, CHU Lyon-Sud, France

    M. Bonnefoy

  7. Service Médecine Interne Gériatrique, CHU Hôpital de Bois-Guillaume, 76031, Rouen Cedex

    P. Chassagne

  8. Service de Rhumatologie, CHU Rangueil, 1, avenue J. Poulhès, 31043, Toulouse cedex

    M. Laroche

  9. C.H.U. Lariboisière Service de Rhumatologie, 2 rue Ambroise Paré, 75475, Paris

    P. Orcel

  10. Hôpital Ch. Foix (Ivry), APHP, Université PM Curie, France

    F. Piette

  11. Centre de Ménopause, Hôpital Paule de Viguier, CHU Toulouse, 330 avenue de Grande-Bretagne, TSA 70034, 31059 Toulouse cedex 9

    C. Ribot & F. Tremollieres

  12. Inserm U858-I2MR, CHU Rangueil, BP84225, 31432, Toulouse cedex 4

    C. Ribot & F. Tremollieres

  13. Service de Médecine, CHU, 49033, Angers cedex 1

    P. Ritz

  14. Hôpital Cochin 27, rue du Fg St Jacques, 75014, Paris

    C. Roux

  15. Pôle Vieillissement, Réadaptation et Accompagnement, AP-HP, Hôpital Universitaire Paul Brousse, 14 Avenue Paul Vaillant Couturier, 94800, Villejuif

    J. Taillandier

  16. CHU Brabois Avenue de Bourgogne, 54500, Vandoeuvre les Nancy, France

    G. Weryha

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  1. Y. Rolland
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Correspondence to Y. Rolland.

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Rolland, Y., van Kan, G.A., Benetos, A. et al. Frailty, osteoporosis and hip fracture: Causes, consequences and therapeutic perspectives. J Nutr Health Aging 12, a319–a330 (2008). https://doi.org/10.1007/BF02982665

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