Abstract
The influence of silicon treatment on the levels of lipid parameters of blood serum and aortic wall was studied in rats. The concentrations of total cholesterol, phospholipids, triglycerides, HDL-cholesterol, LDL-cholesterol, and HDL-phospholipids were measured in sera of rats receivingper os a soluble, inorganic silicon compound — sodium metasilicate nonahydrate (Na2SiO3·9H2O) — dissolved in the drinking water. In the aortic tissue levels of total cholesterol, triglycerides and phospholipids were estimated. An increase in HDL-cholesterol and HDL-phospholipid concentrations, with a simultaneous decrease of LDL-cholesterol and triglyceride levels, was observed in the sera of the tested group. The levels of total cholesterol and phospholipids in the sera, as well as the concentrations of lipids in the aortic walls, showed no significant differences. The results obtained could provide evidence for the existence of an additional mechanism of silicon antiatheromatous action, concerning the modification of activity of enzymatic systems involved in lipids metabolism.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
V. C. Farmer,Silicon Biochemistry, Ciba Found. Symp. 121, D. Evered, ed., Wiley, Chichester, pp. 4–19 (1986).
J. W. Dobbie and H. J. B. Smith,Silicon Biochemistry, Ciba Found. Symp. 121, D. Evered, ed., Wiley, Chichester, pp. 194–209 (1986).
J. H. Austin,Biochemistry of Silicon and Related Problems, G. Bendz and I. Lindquist, eds., Plenum, New York, pp. 255–265 (1978).
G. H. Berlyne, A. J. Adler, N. Ferran, S. Bennett, and J. Holt,Nephron 43, 5–9 (1986).
E. M. Carlisle,Silicon Biochemistry, Ciba Found. Symp. 121, D. Evered, ed., Wiley, Chichester, pp. 123–136 (1986).
Y. Charnot and G. Peres,Biochemistry of Silicon and Related Problems, G. Bendz and I. Lindquist, eds., Plenum, New York, pp. 269–279 (1978).
J. D. Birchall and A. W. Espie,Silicon Biochemistry, Ciba Found. Symp. 121, D. Evered, ed., Wiley, Chichester, pp. 140–153 (1986).
J. A. Edwardson, J. Klinowski, A. E. Oakley, R. H. Perry, and J. M. Candy,Silicon Biochemistry, Ciba Found. Symp. 121, D. Evered, ed., Wiley, Chichester, pp. 160–173 (1986).
J. D. Birchall and J. S. Chappel,Lancet 29, pp. 1008–1010 (1988).
K. Schwarz,Biochemistry of Silicon and Related Problems, G. Bendz and I. Lindquist, eds., Plenum, New York, pp. 207–228 (1978).
J. Loeper, J. Goy-Loeper, L. Rozensztajn, and H. Fragny,Atherosclerosis,33, 397–408 (1979).
K. Schwarz,WHO Chronicle 26, 51 (1973).
K. Schwarz, B. A. Ricci, S. Punsar, and M. J. Karvonen,Lancet 1, 538 (1977).
J. Loeper and M. Fragny,Biochemistry of Silicon and Related Problems, G. Bendz and I. Lindquist, eds., Plenum, New York, pp. 281–294 (1978).
K. Schwarz,Proc. Nat. Acad. Sci. (Wash.) 70, 1608 (1973).
P. F. Holt and S. Osborne,Brit. J. Ind. Med. 10, 152 (1953).
J. Ourilon, A. M. Robert, L. Robert, H. Bouisson, and M. Pieraggi,Paroi Anter. 1, 105 (1973).
J. Loeper, J. Goy, M. Fragny, R. Troniou, and O. Bedu,Life Sciences 42, 2105–2112 (1988).
R. J. Gryglewski, A. Dembińska-Kiec, A. Zmuda, and T. GryglewskaAtherosclerosis 31, 385–394 (1978).
P. De Franciscis, G. Oliviero, and A. M. Greco,Bull. Soc. It. Biol. Sper. 50, 577–581 (1974).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Najda, J., Gminski, J., Drożdż, M. et al. The effect of silicon (Si) on lipid parameters in blood serum and arterial wall. Biol Trace Elem Res 31, 235–247 (1991). https://doi.org/10.1007/BF02990194
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02990194