Skip to main content
SpringerLink
Log in

Iodine content of human tissues after administration of iodine containing drugs or contrast media

  • Published:
Journal of Endocrinological Investigation Aims and scope Submit manuscript

Abstract

Total iodine contents were determined in 209 bioptic or autoptic specimens of various extrathyroidal tissues. Fifty-two of the 80 subjects examined had no previous exposure to excessive iodine, 24 were tested after administration of x-ray contrast media and 4 after treatment with various iodine containing drugs. Unexposed subjects had tissue iodine contents (mean + SD) ranging from 0.85 ± 0.17 μg/100 gin the brain and 9.78 ± 2.75 μg/100 gin the liver of adults. A significantly lower iodine concentration was found in the liver of newborns (2.79 ± 1.00 μg, p<0.001). Most of the other tissues had iodine concentrations of 2–4 μg/100 g. Subjects with previous exposure to iodine containing drugs or x-ray contrast media showed increased iodine contents of various degree in all examined tissues, including adipose tissue, bone, brain, kidney, liver, lung, skeletal muscle, skin and spleen. Accumulation of iodine in adipose tissue was still demonstrable more than two years after cholecystography.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. National Bureau of Standard., Handbook 47 Recommendations of the International Commission on Radiological Protection, 1950.

    Google Scholar 

  2. McClendon J.F. Iodine and the incidence of goitre. University of Minnesota Press, Minneapolis, 1939.

    Google Scholar 

  3. Sturm A., Bucholz B. Beitrage zur Kentniss des Jodstoffwechsels. Dtsch. Klin Med. 161: 129, 1928.

    CAS  Google Scholar 

  4. Salter W.T. Fluctuations in body iodine. Physiol. Rev. 20: 345, 1940.

    CAS  Google Scholar 

  5. Oddie T.H., Meads J.H. Jr., Fischer D.A. An analysis of published data on thyroxine turnover in human subjects. J. Clin. Endocrinol. Metab. 26: 425, 1966.

    Article  PubMed  CAS  Google Scholar 

  6. Riggs D.S. Quantitative aspects of iodine metabolism in man. Pharmacol. Rev. 4: 284, 1952.

    PubMed  CAS  Google Scholar 

  7. Malvano R., Buzzignoli G., Costa A., Cottino F. Iodine determination in human and mouse tissues by neutron-activation analysis. J. Nucl. Biol. Med. 73: 71, 1969.

    Google Scholar 

  8. Klitgaard H.M., Dirks H.B. Jr., Gaelich W.R., Barker G.B. Protein-bound iodine in various tissues after injection of elemental iodine. Endocrinology 50: 170, 1952.

    Article  PubMed  CAS  Google Scholar 

  9. Carr E.A. Jr., Riggs D.S. Protein bound iodine in extrathyroidal tissues. Biochem. J. 54: 217, 1953.

    PubMed  CAS  Google Scholar 

  10. Liewendahl K. Iodochloroxyquinoline and the thyroid gland. Acta Endocrinol. (Kbh) 53 (Suppl): 133, 1968.

    Google Scholar 

  11. Sonksen P.H., Ekins R.P., Stevens H.G., Williams E.S., Nabarro J.D.N. Serum levels of protein-bound iodine and thyroxine after a dose of iodoquinol. Lancet 2: 425, 1968.

    Article  PubMed  CAS  Google Scholar 

  12. Piette G., Savoie J.C., Piette N. Structure et métabolisme de certains composés organoiodés utilisés chez l’homme. Actualités Endocrinologiques, Onziéme Serie, L’Expansion Scientifique Française, Paris, 1970, p. 51.

    Google Scholar 

  13. Jaffiol G., Orsetti A. Incidence des composes de contraste radiologique organo-iodés sur le métabolisme et le transport plasmatique des hormones thyroidiennes. Actualités Endocrinologiques, Onzième Serie. L’Expansion Scientifique Française, Paris, 1970, p. 69.

    Google Scholar 

  14. Thilly C.H., Delange F., Goldstein-Golaire J., Ermans A.M. Endemic goiter prevention by iodized oil. J. Clin. Endocrinol. Metab. 36: 1196, 1973.

    Article  PubMed  CAS  Google Scholar 

  15. Medeiros-Neto G.A., Nicolau W., Takeda A., Ulhoa Cintra A.B. Effect of iodized oil on iodine content, thyroglobulin maturation, and on biochemical constituents of endemic goitre in Brazil. Acta Endocrinol. (Kbh) 79: 439, 1975.

    PubMed  CAS  Google Scholar 

  16. Cottino F., Zoppetti G., Favero A., Lombardi M., Cenderelli G., Costa A. Placental tissue and maternal and cord serum iodine following pharmacological loading. Folia Endocrinol. (Roma) 25: 278, 1972.

    CAS  Google Scholar 

  17. Costa A., Bacci R., Cottino F., Listorto G., Zoppetti G. Ricerche sul ricambio dello iodio dopo interventi distrumectomia totale e subtotale. Minerva Med. 67: 5918, 1970.

    Google Scholar 

  18. Malvano R., Buzzigoli G., Scarlattini M., Cenderelli G., Gandolfi G., Grosso P. The determination of iodine in materials of biological interest. Anal. Chem. Acta 67: 201, 1972.

    Article  Google Scholar 

  19. Altman P.L., Dittmer D.S. Biology data book. Federation of American Societies for experimental biology, Washington, 1964.

    Google Scholar 

  20. Gambino S.R., Schreiber H., Covolo C. In: Skeggs L.T. (Ed.), Automation in analytical chemistry, Medical Inc., New York, 1966, p. 363.

  21. Pitt-Rivers R., Tata J.R. The thyroid hormones. Pergamon Press, London, 1959, p. 135.

    Google Scholar 

  22. Alpers J.B., Rall J.E. The metabolism of iodine in cerebrospinal fluid. J. Clin. Endocrinol. Metab. 75: 1482, 1955.

    Article  Google Scholar 

  23. Wolff J., Thompson R.H., Robbins J. Congenital goitrous cretinism due to the absence of iodide concentrating ability. J. Clin. Endocrinol. Metab. 24: 699, 1964.

    Article  PubMed  CAS  Google Scholar 

  24. Costa A., Brambati-Testori O., Cenderelli G., Patrito G., Piazza A. Incidence of goitre in Piedmont schoolchildren and notes of the iodine content of certain foodstuffs. Panminerva Med. 17: 107, 1975.

    Google Scholar 

  25. Platzer S., Fill H., Riccabona G., Glatzl J., Seidl J., Cenderelli G., Migliardi M., Varetto H., Costa A. Endemic goiter in Alto Adige (Italy). Acta Endocrinol. (Kbh) 85: 325, 1977.

    CAS  Google Scholar 

  26. Platzer S., Riccabona G., Fill H., Laudurner D., Glatzl J., De Sanso G., Brambati-Testori O., Costa A. Notes on endemic goitre and cretinism in the upper Isarco Valley. J. Nucl. Biol. Med. 19: 65, 1975.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Endemic Goiter Study Center, Mauriziano Hospital, Torino, Italy

    A. Costa & M. Migliardi

  2. Department of Endocrinology, Mauriziano Hospital, Torino, Italy

    O. Brambati Testori & C. Cenderelli

  3. First Department of Surgery, Mauriziano Hospital, Torino, Italy

    G. Giribone

Authors
  1. A. Costa
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. O. Brambati Testori
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. C. Cenderelli
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. G. Giribone
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. M. Migliardi
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Costa, A., Brambati Testori, O., Cenderelli, C. et al. Iodine content of human tissues after administration of iodine containing drugs or contrast media. J Endocrinol Invest 1, 221–225 (1978). https://doi.org/10.1007/BF03350384

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03350384

Key-words

Search

Navigation