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Association of IL-10 -1082A>G, -819C>T, and -592C>A polymorphisms with susceptibility to chronic and aggressive periodontitis: a systematic review and meta-analysis

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Abstract

Objectives

Several epidemiological studies have evaluated association of interleukin 10 (IL-10) polymorphisms with risk of periodontitis. However, the results remain conflicting and inconclusive. Here, we carried out a comprehensive systematic review and meta-analysis to evaluate the association of IL-10 -1082A>G, -819C>T, and -592C>A polymorphisms with risk of chronic (CP) and aggressive (CP) periodontitis.

Methods

Electronic databases including PubMed, Science Direct, SciELO, and CNKI were systematically searched to identify all relevant studies published up to 01 June 2020.

Results

A total of 60 case–control studies with 5313 cases and 6528 controls met our inclusion criteria. Overall, the pooled data showed that the IL-10 -592C>A polymorphism was statistically associated with increased risk of periodontitis in the overall population, while no significant association was identified for IL-10 -1082A>G and IL-10 -819C>T polymorphisms. The subgroup analysis by ethnicity revealed that the IL-10 -1082A>G polymorphism was significantly associated with periodontitis risk in Caucasians, IL-10 -819C>T polymorphism in mixed population, and IL-10 -592C>A polymorphism in both Asians and mixed populations. When further analyzed by periodontitis type, only the IL-10 -592C>A polymorphism was associated with CP risk, but not AgP; and the IL-10 -1082A>G and -819C>T polymorphisms have not positive association neither in the CP and AgP.

Conclusions

The current meta-analysis showed that the IL-10 -592C>A polymorphism was statistically associated with periodontitis risk in the overall population. Moreover, the IL-10 -1082A>G, IL-10 -819C>T, and IL-10 -592C>A polymorphisms were associated with periodontitis risk by ethnicity. Therefore, the IL-10 polymorphisms are of high clinical relevance by ethnicity and would be a useful marker to identify patients who are at higher risk for periodontitis.

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Authors and Affiliations

  1. Department of Oral and Maxillofacial Pathology, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Fatemeh Mashhadiabbas

  2. Department of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

    Seyed Alireza Dastgheib & Karim Daliri

  3. Department of Pharmaceutics, Faculty of Pharmacology, Tehran University of Medical Sciences, Tehran, Iran

    Ahmad Hashemzehi

  4. Department of Pediatric Dentistry, School of Dentistry, Oral Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

    Zahra Bahrololoomi

  5. Department of Medical Laboratory Sciences, School of Paramedical Science, Shiraz University of Medical Sciences, Shiraz, Iran

    Fatemeh Asadian

  6. Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

    Hossein Neamatzadeh & Masoud Zare-Shehneh

  7. Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

    Hossein Neamatzadeh

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  1. Fatemeh Mashhadiabbas
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Contributions

FM, SAD, AH: conceptualization. HN, SAD: software, investigation, writing, original draft preparation. FA and ZB: investigation. MZS, KD: investigation, writing. HN, SAD: methodology, software. FM, SAD, HN, ZB: writing, reviewing, editing.

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Correspondence to Ahmad Hashemzehi.

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Communicated by John Di Battista.

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Mashhadiabbas, F., Dastgheib, S.A., Hashemzehi, A. et al. Association of IL-10 -1082A>G, -819C>T, and -592C>A polymorphisms with susceptibility to chronic and aggressive periodontitis: a systematic review and meta-analysis. Inflamm. Res. 70, 509–524 (2021). https://doi.org/10.1007/s00011-021-01448-z

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