Abstract
YAP and TAZ are ubiquitously expressed homologous proteins originally identified as penultimate effectors of the Hippo signaling pathway, which plays a key role in maintaining mammalian tissue/organ size. Presently, it is known that YAP/TAZ also interact with various non-Hippo signaling pathways, and have diverse roles in multiple biological processes, including cell proliferation, tissue regeneration, cell lineage fate determination, tumorigenesis, and mechanosensing. In this review, we first examine the various microenvironmental cues and signaling pathways that regulate YAP/TAZ activation, through the Hippo and non-Hippo signaling pathways. This is followed by a brief summary of the interactions of YAP/TAZ with TEAD1-4 and a diverse array of other non-TEAD transcription factors. Finally, we offer a critical perspective on how increasing knowledge of the regulatory mechanisms of YAP/TAZ signaling might open the door to novel therapeutic applications in the interrelated fields of biomaterials, tissue engineering, regenerative medicine and synthetic biology.
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References
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Acknowledgments
This work was supported by the National Key R&D Program of China (Grant No. 2018YFC1105303/04), National Natural Science Foundation of China (Grant Nos. 51772006, 31670993, 51973004, 81991505), Beijing Municipal Science & Technology Commission Projects (Grant No. Z181100002018001), and Peking University Medicine Fund (Grant Nos. PKU2020LCXQ009, BMU2020PYB029).
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Boon Chin Heng and Xuehui Zhang contributed equally to this work.
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Heng, B.C., Zhang, X., Aubel, D. et al. An overview of signaling pathways regulating YAP/TAZ activity. Cell. Mol. Life Sci. 78, 497–512 (2021). https://doi.org/10.1007/s00018-020-03579-8
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DOI: https://doi.org/10.1007/s00018-020-03579-8