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New Pt(II) complexes with 3’-methyl tetrahydro-4H-thiopyranspiro-5’-hydantoin: synthesis, theoretical and cytotoxic investigation

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Abstract

Three new platinum complexes with chemical formulas cis-[PtL2Cl2], cis-[PtL2I2] and cis-[PtL(NH3)Cl2], where L is 3’-methyl-4-thio-1H-tetrahydropyranspiro-5’-hydantoin were synthesized and studied. The spectral and theoretical investigations proved that ligand coordinates through sulfur atom from tetrahydrothiopyrane fragment by monodentate manner with platinum ion. The newly synthesized compounds were tested for cytotoxic activity in vitro against four human tumor cell lines using MTT dye-reduction assay for cell viability. The tested compounds displayed cytotoxic effects in a concentration-dependent manner. Complex 2 as well as complex 3 have similar cytotoxicity to that of the prototype drug cisplatin on colon adenocarcinoma model HT-29.

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Acknowledgements

The financial support of this work by the Medical Science Council at the Medical University – Sofia within the Grant no. 84/23.04.2019 is gratefully acknowledged.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Pharmacy, Medical University–Sofia, 1000, Sofia, Bulgaria

    Adriana Georgieva Bakalova, Rossen Todorov Buyukliev & Emilyia Demireva Cherneva

  2. Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Sofia, Bulgaria

    Emilyia Demireva Cherneva

Authors
  1. Adriana Georgieva Bakalova
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  2. Rossen Todorov Buyukliev
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  3. Emilyia Demireva Cherneva
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Correspondence to Adriana Georgieva Bakalova.

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Bakalova, A.G., Buyukliev, R.T. & Cherneva, E.D. New Pt(II) complexes with 3’-methyl tetrahydro-4H-thiopyranspiro-5’-hydantoin: synthesis, theoretical and cytotoxic investigation. Med Chem Res 29, 2218–2223 (2020). https://doi.org/10.1007/s00044-020-02639-9

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  • DOI: https://doi.org/10.1007/s00044-020-02639-9

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