Zusammenfassung
Kohortenstudien bieten die Möglichkeit, Behandlungs- und Präventionsansätze für psychische Krankheiten zu präzisieren, wenn sowohl genetische und Persönlichkeitseinflüsse als auch soziokulturelle und Umweltfaktoren sowie das Zusammenspiel dieser Wirkfaktoren berücksichtigt werden. Wir stellen Ansätze der Kohortenforschung vor, die sich diesem Ziel widmen und berichten von bisherigen Erfahrungen mit der IMAGEN-Kohortenstudie und den daraus resultierenden Weiterentwicklungen. Hierbei behandeln wir insbesondere neuartige Erhebungsinstrumente, die Umsetzung größerer klinischer und geografischer Reichweite sowie innovative Datenanalysen.
Abstract
Cohort studies provide the possibility to more precisely define treatment and preventive approaches to mental diseases, when genetic and personal influences as well as sociocultural and environmental factors and their interactions are taken into account. This article presents cohort research approaches, which are dedicated to this aim and reports the lessons learnt and achievements made in the IMAGEN cohort study and the resulting further developments. Specifically, we focus on novel assessment instruments, the implementation of larger clinical and geographic ranges and innovative forms of data analysis.
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Förderung
Diese Arbeit wurde aus folgenden Mitteln finanziert: dem IMAGEN-Projekt (Reinforcement-related behaviour in normal brain function and psychopathology; LSHM-CT-2007-037286) im 6. Rahmenprogramm der Europäischen Union (6FP), ERC Advanced Grant „STRATIFY“ (Brain netword based stratification of reinforcement-related disorders; 695313) im Forschungs- und Innovationsprogramm Horizon 2020 der Europäischen Union, „c-VEDA“ aus der Newton Förderung des Medical Research Council (MR/N000390/1), Bundesministerium für Bildung und Forschung (BMBF Fördernummern 01GS08152; 01EV0711; eMED SysAlc01ZX1311A; Forschungsnetz AERIAL 01EE1406A, 01EE1406B, PD-CAN 01EE1406I), der Deutsche Forschungsgemeinschaft (DFG Fördernummern SM 80/7‑2, SFB 940/2 und SFB TRR 265 [Addiction Research Consortium: Loosing and regaining control over drug intake – ReCoDe]), der Medical Research Foundation des Medical Research Council (MR/R00465X/1) und dem Human Brain Project (HBP SGA 2, 785907, HBP SGA 3, 945539). Weitere Unterstützung erfolgte durch die NIH-Konsortialförderung U54 EB020403, unterstützt von einer NIH-übergreifenden Allianz, der „Big Data and Knowledge Centers of Excellence“.
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und M. Rapp war Berater von Eli Lilly und Fa. Dr. W. Schwabe. Er hat von Phillips und Eli Lilly Vortragshonorare erhalten. G. Schumann, M. Tschorn und A. Heinz geben an, dass kein Interessenkonflikt besteht.
Alle beschriebenen Untersuchungen am Menschen oder an menschlichem Gewebe wurden mit Zustimmung der zuständigen Ethikkommission, im Einklang mit nationalem Recht sowie gemäß der Deklaration von Helsinki von 1975 (in der aktuellen, überarbeiteten Fassung) durchgeführt. Von allen beteiligten Patienten liegt eine Einverständniserklärung vor.
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Schumann, G., Tschorn, M., Heinz, A. et al. Jenseits von IMAGEN: populationsneurowissenschaftliche Strategien für klinische und globale Kohorten in den STRATIFY- und GIGA-Konsortien. Nervenarzt 92, 234–242 (2021). https://doi.org/10.1007/s00115-020-01059-9
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DOI: https://doi.org/10.1007/s00115-020-01059-9