Zusammenfassung
Immer häufiger stellen sich Patienten mit einer erektilen Dysfunktion (ED) nach beckenchirurgischen Eingriffen in urologischen Praxen vor, wobei es sich in den allermeisten Fällen um Patienten nach radikalen Prostatovesikulektomieoperationen handelt. Trotz Erhaltung des Gefäßnervenbündels tritt in mindestens 50% der Fälle eine ED auf. Dieser Artikel diskutiert die verschiedenen Ursachen und theoretischen Ansätze der Therapie. Dabei werden lebensstilverändernde Maßnahmen, die Unterstützung der Neuroregeneration und die damit verbundene Verhinderung der Apoptose der glatten Muskulatur des Corpus cavernosum und die Verbesserung der Schwellkörpercompliance durch eine verbesserte Oxygenierung angesprochen. Einige dieser Therapieansätze werden in der internationalen Literatur als viel versprechend diskutiert, wobei die frühzeitige Rehabilitation der Erektionsfähigkeit sinnvoll zu sein scheint. Man vermutet, dass die natürliche Wiedererlangung der erektilen Funktion nach beckenchirurgischen Eingriffen häufig bis zu 2 Jahre oder länger dauert, wobei dieser Zeitraum allem Anschein nach durch eine effektive Rehabilitation verkürzt werden kann.
Abstract
Increasingly, urologists are seeing patients with erectile dysfunction after pelvic operations. In most cases, radical prostatectomy is the cause. Even when a nerve-sparing procedure is performed, approximately 50% of the patients suffer from erectile dysfunction. This report discusses the causes and theoretical therapies, including lifestyle changes, strategies for neuroregeneration and the associated prevention of apoptosis of the smooth muscle of the corpus cavernosum and improvement of the corpora cavernosa by increased oxygenation. According to the international literature, many of these agents and lifestyle modifications display promise for treating impotence. Early treatment for patients recovering from pelvic operations seems to be reasonable. It is assumed that the natural recovery of erections may take as long as 18 to 24 months postsurgery or even longer; however, treatment modalities may reduce the time to erectile recovery.
Literatur
Burnett AL (2003) Strategies to promote recovery of cavernous nerve function after radical prostatectomy. World J Urol 20: 337–342
Walsh PC, Donker PJ (1982) Impotence following radical prostatectomy: insight into etiology and prevention. J Urol 128: 492–497
Walsh PC (1988) Preservation of sexual function in the surgical treatment of pro staticcancer – an anatomic surgical approach. In: Devita VT, Hellman S, Rosenberg S (eds) Important advances in oncology. Lippincott, Philadelphia, pp 161–170
Graefen M, Walz J, Huland H (2006) Open retropubic nerve-sparing radical prostatectomy. Eur Urol 49: 38–48
Michl UH, Friedrich MG, Graefen M et al. (2006) Prediction of postoperative sexual function after nerve sparing radical retropubic prostatectomy. J Urol 176: 227–231
Walsh PC, Marschke P, Ricker D, Burnett AL (2000) Patient-reported urinary continence and sexual function after anatomic radical prostatectomy. Urology 55: 58–61
Rabbani F, Stapleton AM, Kattan MW et al. (2000) Factors predicting recovery of erections after radical prostatectomy. J Urol 164: 1929–1934
Sommer F, Peters, Klotz T et al. (2002) Sport und Bewegung in der Prävention urologischer Erkrankungen. Urologe B 42: 297–305
Esposito K, Giugliano D (2005) Obesity, the metabolic syndrom, and sexual dysfunktion. Int J Imp Res 17: 391–398
Dorland’s Illustrated Medical Dictionary (1988) Dorland’s Illustrated Medical Dictionary, 27th edn. Saunders, Philadelphia, p 1126
McCullough AR (2001) Prevention and management of erectile dysfunction following radical prostatectomy. Urol Clin North Am 28: 613–627
Quinlan DM, Epstein JI, Carter BS, Walsh PC (1991) Sexual function following radical prostatectomy: influence of preservation of neurovascular bundles. J Urol 145: 998–1002
Walsh PC, Marschke P, Ricker D, Burnett AL (2000) Use of intraoperative video documentation to improve sexual function after radical retropubic prostatectomy. Urology 55: 62–67
Podlasek CA, Gonzalez CM, Zelner DJ et al. (2001) Analysis of NOS isoform changes in a post radical prostatectomy model of erectile dysfunction. Int J Impot Res 13(Suppl 5): 1–15
Zagaja GP, Mhoon DA, Aikens JE, Brendler CB (2000) Sildenafil in the treatment of erectile dysfunction after radical prostatectomy. Urology 56: 631–634
Zippe CD, Jhaveri FM, Klein EA et al. (2000) Role of Viagra after radical prostatectomy. Urology 55: 241–245
Wespes E, de Goes PM, Schulman CC (1998) Age-related changes in the quantification of the intracavernous smooth muscles potent men. J Urol 159(Suppl 5): 99
Wespes E (2002) Smooth muscle pathology and erectile dysfunction. Int J Impot Res 14(Suppl 1): 17–21
Bondil P, Costa P, Daures JP et al. (1992) Clinical study of the longitudinal deformation of the flaccid penis and of its variations with aging. Eur Urol 21: 284–286
Fraiman MC, Lepor H, McCullough AR (1999) Changes in penile morphometrics in men with erectile dysfunction after nerve-sparing radical retropubic prostatectomy. Mol Urol 3: 109–115
Klein LT, Miller MI, Buttyan R et al. (1997) Apoptosis in the rat penis after penile denervation. J Urol 158: 626–630
User HM, Hairston JH, Zelner DJ et al. (2003) Penile weight and cell subtype specific changes in a post-radical prostatectomy model of erectile dysfunction. J Urol 169: 1175–1179
Polascik TJ, Walsh PC (1995) Radical retropubic prostatectomy: the influence of accessory pudendal arteries on the recovery of sexual function. J Urol 154: 150–152
Tarhan F, Kuyumcuoglu U, Kolsuz A et al. (1997) Cavernous oxygen tension in the patients with erectile dysfunction. Int J Impot Res 9: 149–153
Mersdorf A, Goldsmith PC, Diederichs W et al. (1991) Ultrastructural changes in impotent penile tissue: a comparison of 65 patients. J Urol 145: 749–785
Krane RJ, Goldstein I, Saenz de Tejada I (1989) Impotence. Medical Progress. N Engl J Med 321: 1648–1659
Lerner SE, Melman A, Christ GJ (1993) A review of erectile dysfunction: new insights and more questions. J Urol 149: 1246
Moreland RB (1998) Is there a role of hypoxemia in penile fibrosis: a viewpoint presented to the Society for the Study of Impotence. Int J Impot Res 10: 113–120
Wilborn J, Croffrod LJ, Burdick MD et al. (1995) Cultured lung fibroblasts isolated from patients with idiopathie pulmonary fibrosis have a diminished capacity to synthesize prostaglandin E2 and to express cyclooxygenase-2. J Clin Inv 95: 1861–1868
Kim N, Vardi Y, Padma-Nathan H et al. (1993) Oxygen tension regulates the nitric oxide pathway. Physiological role in penile erection. J Clin Invest 91: 437–442
Halverson HM (1940) Genital and sphincter behavior of the male infant. J Gen Psychol 56: 95
Fischer C, Gross J, Zuch J (1965) Cycle of penile erections synchronous with dreaming (REM) sleep: preliminary report. Arch Gen Psychiatry 12: 29–45
Karacan I, Williams R, Salis P (1970) The effect of sexual intercourse in sleep patterns and nocturnal penile erections. Psychophysiology 7: 338
Karacan I (1986) Erectile dysfunction in narcoleptic patients. Sleep 9: 227–231
Montorsi F, Maga T, Strambi LF et al. (2000) Sildenafil taken at bedtime significantly increases nocturnal erections: results of a placebo-controlled study. Urology 56: 906–911
Moreland RB, Traish A, McMillin MA et al. (1995) PGE1 suppresses the induction of collagen synthesis by transforming growth factor-beta 1 in human corpus cavernosum smooth muscle. J Urol 153: 826–834
Muller A, Mulhall JP (2006) Cardiovascular disease, metabolic syndrome and erectile dysfunction. Curr Opin Urol 16: 435–443
Wirth A, Manning M, Büttner H (2007) Metabolic syndrome and erectile dysfunction. Epidemiologic associations and pathogenetic links. Urologe A 46: 287–292
Van der Horst C, Martinez Portill FJ, Banowsky A et al. (2003) Early erectile function after catheter removal in patients undergoing nerve-sparing prostatectomy. Int J Impot Res 15(Suppl 6): 13
Montorsi F, Guazzoni G, Strambi LF (1997) Recovery of spontaneous erectile function after nerve-sparing radical retropubic prostatectomy with and without early intracavernous injections of alprostadil: results of a prospective, randomized trail. J Urol 158: 1408–1410
Montorsi F, Briganti A, Salonia A et al. (2004) Current and future strategies for prevention and managing erectile dysfunction following radical prostatektomy. Eur Urol 45: 123–133
Sommer F, Mathers MJ (2007) Lifestyle, erektile Dysfunktion, Hormone, metabolisches Syndrom – Möglichkeiten einer geschlechtsspezifischen männlichen Prävention. Urologe 46: 628–635
Mathers MJ, Rundstedt F v, Lazica DA, Sommer F (2008) Diet-induced weight loss vs. exercise-induced weight loss: is there an effect on erectile dysfunction in obese men? European Urology (in press)
Wespes E, Amar E, Hatzichristou D et al. (2006) EAU Guidelines on erectile dysfunction: an update. Eur Urol 49: 806–815
Travison TG, Shabsigh R, Araujo AB et al. (2007) The natural progression and remission of erectile dysfunction: results from the Massachusetts Male Aging Study. J Urol 177: 241–246
Bacon CG, Mittleman MA, Kawachi I et al. (2003) Sexual function in men older than 50 years of age: results from the health professionals follow-up study. Ann Intern Med 139: 161–168
Blanker MH, Bohnen AM, Groeneveld FP et al. (2001) Correlates for erectile and ejaculatory dysfunction in older Dutch men: a community-based study. J Am Geriatr Soc 49: 436–442
Martin-Morales A, Sanchez-Cruz JJ, Saenz de Tejada I et al. (2001) Prevalence and independent risk factors for erectile dysfunction in Spain: results of the Epidemiologia de la Disfuncion Erectil Masculina Study. J Urol 166: 569–575
Mirone V, Imbimbo C, Bortolotti A et al. (2002) Cigarette smoking as risk factor for erectile dysfunction: results from an Italian epidemiological study. Eur Urol 41: 294–297
Feldman HA, Johannes CB, Derby CA et al. (2000) Erectile dysfunction and coronary risk factors: prospective results from the Massachusetts male aging study. Prev Med 30: 328–338
Laumann EO, Paik A, Rosen RC (1999) Sexual dysfunction in the United States: prevalence and predictors. Jama 281: 537–544
Derouet H, Nolden W, Jost WH et al. (1998) Treatment of erectile dysfunction by an external ischiocavernous muscle stimulator. Eur Urol 34: 355–359
Gontero P, Fontana F, Bagnasacco A et al. (2003) Is there an optimal time for intracavernous prostaglandin E1 rehabilitation following nonnerve sparing radical prostatectomy? Results from a hemodynamic prospective study. J Urol 169: 2166–2169
Sommer F, Heidenreich A, Reddy P, Derakhshani P (1999) Vergleich von Effektivität und Nebenwirkungen der Therapie mit MUSE und SKAT. 45. Tagung der Nordrhein-Westfälischen Gesellschaft für Urologie, Münster 16.04
Mathers MJ, Klotz T, Brandt AS et al. (2008) Long-term treatment of erectile dysfunction with a phosphodiesterase-5 inhibitor and dose optimization based on nocturnal penile tumescence. BJU Int 10 (Epub ahead of print)
Padma-Nathan H, McCullough A, Forest C (2004) Erectile dysfunction secondary to nerve-sparing radical retropubic prostatectomy: comparative phosphodiesterase-5 inhibitor efficacy for therapy and novel prevention strategies. Curr Urol Rep 5: 467–471
Sommer F, Schulze W (2005) Treating erectile dysfunction by endothelial rehabilitation with phosphodiesterase 5 inhibitors. World J Urol 23: 385–392
Zhang XH, Hu LQ, Chen J et al. (2002) The rat model of erectile dysfunction caused by cavernous nerve injury. Zhonghua Nan Ke Xue 8: 120–121
Mulhall J, Land S, Parker M et al. (2005) The use of an erectogenic pharmacotherapy regimen following radical prostatectomy improves recovery of spontaneous erectile function. J Sex Med 2: 532–540
Herkommer K, Geschwend J, Jerzinowski N et al. (2006) Versorgung der erektilen Dysfunktion nach radikaler Prostatektomie in Deutschland. Urologe 1: 135
Herkommer K, Niespodziany S, Zorn C et al. (2006) Versorgung der erektilen Dysfunktion nach radikaler Prostatektomie in Deutschland. Urologe 45: 336–342
Gontero P, Fontana F, Zitella A et al. (2005) A prospective evaluation of efficacy and compliance with a multistep treatment approach for erectile dysfunction in patients after non-nerve sparing radical prostatectomy. BJU Int 95: 359–365
Bannowsky A, Schulze H, van der Horst C et al. (2005) Erectile function after nerve-sparing radical prostatectomy. Nocturnal early erection as a parameter of postoperative organic erectile integrity. Urologe A 44: 521–526
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Mathers, M., Klotz, T., Vahlensieck, W. et al. Ist eine Rehabilitation der erektilen Funktion nach beckenchirurgischen Eingriffen sinnvoll?. Urologe 47, 685–692 (2008). https://doi.org/10.1007/s00120-008-1668-7
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DOI: https://doi.org/10.1007/s00120-008-1668-7