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Maternale Schadstoffexposition und kindliche (intrauterine) Entwicklung

Maternal exposure to pollutants and child (intrauterine) development

  • Leitthema
  • Published:
Der Gynäkologe Aims and scope

Zusammenfassung

Hintergrund

Die Exposition gegenüber Umweltgiften ist ubiquitär in industrialisierten Ländern.

Fragestellung

Expositionsrouten und gesundheitsrelevante Effekte besonders mit Blick auf die Reproduktion bei Frauen und der intrauterinen Entwicklung von Kindern sowie perinatale Programmierung.

Material und Methoden

Auswertung und Reflektion aktueller Publikationen zum Thema mit Darstellung neuster Erkenntnisse und relevanter Zukunftsperspektiven.

Ergebnisse

Durch epidemiologische Studien gilt als gesichert, dass Menschen und Tiere heute einer Vielzahl von Umweltgiften ausgesetzt sind und trotz strenger Grenzwerte gesundheitsrelevante Effekte nicht ausgeschlossen werden können, sondern als sehr wahrscheinlich gelten. Mechanistische Untersuchungen tragen zum besseren Verständnis und zur Verdeutlichung der Dringlichkeit bei.

Schlussfolgerung

Mit weiterführenden epidemiologischen und experimentellen Studien können Bedeutung und Risiken für die Reproduktion und die kindliche Entwicklung durch Umweltgifte besser ergründet und politische Entscheidungsfindung sowie medizinische Prävention von Gesundheitseffekten vorangetrieben werden.

Abstract

Background

Exposure to environmental chemicals is ubiquitous in industrialized countries.

Objectives

Defining paths of exposure and health-related effects with regard to female reproductive parameters, perinatal programming and intrauterine fetal development.

Methods

Evaluation of and reflection on the recent body of literature on this topic and a presentation of novel findings and relevant future perspectives.

Results

Epidemiologic studies have proven that, in today’s environment, humans and animals alike are exposed to environmental toxicants and that, despite strict regulations, health effects cannot be ruled out, but appear instead highly likely. Mechanistic research can contribute to a better understanding of these threats and highlight their urgency.

Conclusions

Following novel epidemiologic and experimental studies, the significance of and risks to reproduction and infant development from environmental toxicants can be better understood and political decision-making and medical prevention of health effects further advanced.

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Author information

Authors and Affiliations

  1. Department Umweltimmunologie, Helmholtz Zentrum für Umweltforschung – UFZ, Permoserstr. 15, 04318, Leipzig, Deutschland

    Tobias Kretschmer &  Ana C. Zenclussen

  2. Perinatale Immunologie, Sächsischer Inkubator für klinische Translation (SIKT), Medizinische Fakultät, Universität Leipzig, Leipzig, Deutschland

    Ana C. Zenclussen

Authors
  1. Tobias Kretschmer
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  2. Ana C. Zenclussen
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Corresponding author

Correspondence to Ana C. Zenclussen.

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Interessenkonflikt

T. Kretschmer und A.C. Zenclussen geben an, dass kein Interessenkonflikt besteht.

Für diesen Beitrag wurden von den Autoren keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.

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B. Sonntag, Hamburg

G. Emons, Göttingen

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Kretschmer, T., Zenclussen, A.C. Maternale Schadstoffexposition und kindliche (intrauterine) Entwicklung. Gynäkologe 54, 253–259 (2021). https://doi.org/10.1007/s00129-021-04778-5

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  • DOI: https://doi.org/10.1007/s00129-021-04778-5

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