Abstract
Scutellaria baicalensis (SB), also known as the Chinese skullcap, has a long history of being used in Chinese medicine to treat a variety of conditions ranging from microbial infections to metabolic syndrome and malignancies. Numerous studies have reported that treatment with total SB extract or two main flavonoids found in its root and leaves, baicalin (BA) and baicalein (BE), can prevent or alleviate the detrimental toxic effects of exposure to various chemical compounds. It has been shown that BA and BE are generally behind the protective effects of SB against toxicants. This paper aimed to review the protective and therapeutic effects of SB and its main components BA and BE against chemical compounds that can cause intoxication after acute or chronic exposure and seriously affect different vital organs including the brain, heart, liver, and kidneys. In this review paper, we had a look into a total of 221 in vitro and in vivo studies from 1995 to 2021 from the scientific databases PubMed, Scopus, and Web of Science which reported protective or therapeutic effects of BA, BE, or SB against drugs and chemicals that one might be exposed to on a professional or accidental basis and compounds that are primarily used to simulate disease models. In conclusion, the protective effects of SB and its flavonoids can be mainly attributed to increase in antioxidants enzymes, inhibition of lipid peroxidation, reduction of inflammatory cytokines, and suppression of apoptosis pathway.
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Abbreviations
- AD:
-
Alzheimer’s disease
- Akt:
-
Protein kinase B
- ALP:
-
Alkaline phosphatase
- ALT:
-
Alanine aminotransferase
- APAP:
-
Acetaminophen
- AST:
-
Aspartate aminotransferase
- BA:
-
Baicalin
- BE:
-
Baicalein
- BaP:
-
Benzo(a)pyrene
- BLM:
-
Bleomycin
- BUN:
-
Blood urea nitrogen
- CAT:
-
Catalase
- Cd:
-
Cadmium
- CORT:
-
Corticosterone
- COX-2:
-
Cyclooxygenase-2
- DA:
-
Dopamine
- DOX:
-
Doxorubicin
- ERK:
-
Extracellular signal-regulated kinases
- ET-1:
-
Endothelin-1
- GSH:
-
Glutathione
- HO-1:
-
Heme oxygenase-1
- IκBα:
-
Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor alpha
- IL:
-
Interleukin
- iNOS:
-
Inducible nitric oxide synthase
- i.p.:
-
Intraperitoneal
- JNK:
-
C-Jun N-terminal kinase
- Keap1:
-
Kelch-like epichlorohydrin–associated protein 1
- LDH:
-
Lactate dehydrogenase
- MAPK:
-
Mitogen-activated protein kinase
- MDA:
-
Malondialdehyde
- MMP:
-
Mitochondrial membrane potential
- MMPs:
-
Matrix metalloproteinases
- NF-κB:
-
Nuclear factor kappa-light-chain-enhancer of activated B cells
- NMDA:
-
N-methyl-d-aspartate
- NO:
-
Nitric oxide
- NQO-1:
-
NAD(P)H quinone dehydrogenase-1
- Nrf2:
-
Nuclear factor erythroid 2–related factor 2
- NTG:
-
Nitroglycerin
- Pb:
-
Lead
- PD:
-
Parkinson’s disease
- PI3K:
-
Phosphoinositide 3-kinase
- PPAR:
-
Peroxisome proliferator–activated receptor
- ROS:
-
Reactive oxygen species
- SB:
-
Scutellaria baicalensis
- SBE:
-
Scutellaria baicalensis extract
- Scr:
-
Serum creatinine
- SIRT1:
-
Sirtuin 1
- SOD:
-
Superoxide dismutase
- STZ:
-
Streptozotocin
- t-BHP:
-
Tert-Butyl hydroperoxide
- TCM:
-
Traditional Chinese medicine
- TG:
-
Triglyceride
- TGF:
-
Transforming growth factor
- Th:
-
T helper
- TLR:
-
Toll-like receptor
- TNF-α:
-
Tumor necrosis factor-α
- Treg:
-
T regulator
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Ahmadi, A., Mortazavi, Z., Mehri, S. et al. Scutellaria baicalensis and its constituents baicalin and baicalein as antidotes or protective agents against chemical toxicities: a comprehensive review. Naunyn-Schmiedeberg's Arch Pharmacol 395, 1297–1329 (2022). https://doi.org/10.1007/s00210-022-02258-8
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DOI: https://doi.org/10.1007/s00210-022-02258-8