Skip to main content
SpringerLink
Log in

Call to arms: need for radiobiology in molecular radionuclide therapy

  • Letter to the Editor
  • Published:
European Journal of Nuclear Medicine and Molecular Imaging Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Strosberg J, et al. Phase 3 trial of 177Lu-Dotatate for midgut neuroendocrine tumors. N Engl J Med. 2017;376(2):125–35.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Parker C, et al. Alpha emitter radium-223 and survival in metastatic prostate cancer. N Engl J Med. 2013;369(3):213–23.

    Article  CAS  PubMed  Google Scholar 

  3. Verheijen RH, et al. Phase III trial of intraperitoneal therapy with yttrium-90-labeled HMFG1 murine monoclonal antibody in patients with epithelial ovarian cancer after a surgically defined complete remission. J Clin Oncol. 2006;24(4):571–8.

    Article  CAS  PubMed  Google Scholar 

  4. Bodei L, et al. Long-term tolerability of PRRT in 807 patients with neuroendocrine tumours: the value and limitations of clinical factors. Eur J Nucl Med Mol Imaging. 2015;42(1):5–19.

    Article  CAS  PubMed  Google Scholar 

  5. Del Prete M, et al. Personalized 177Lu-octreotate peptide receptor radionuclide therapy of neuroendocrine tumours: initial results from the P-PRRT trial. Eur J Nucl Med Mol Imaging. 2019;46(3):728–42.

    Article  CAS  PubMed  Google Scholar 

  6. Pouget JP, et al. Introduction to radiobiology of targeted radionuclide therapy. Front Med. 2015;2:12.

    Article  Google Scholar 

  7. European Association of Nuclear Medicine Internal Dosimetry Task Force Report, Treatment planning for molecular radiotherapy: potential and prospects. Flux G, Stokke C., editors. 2017.

  8. European Council Directive. 2013/59/Euratom of 5 December 2013 laying down basic safety standards for protections against the dangers arising from exposure to ionising radiation, and repealing Directives 89/618/Euratom, 90/641/Euratom, 96/29/Euratom, 97/43/Euratom and 2003/122/Euratom. Off J Eur Union. 2014.

  9. Prise KM, O’Sullivan JM. Radiation-induced bystander signalling in cancer therapy. Nat Rev Cancer. 2009;9(5):351–60.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Nonnekens J, et al. Potentiation of peptide receptor radionuclide therapy by the PARP inhibitor olaparib. Theranostics. 2016;6(11):1821–32.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

The authors would like to acknowledge Mark Konijnenberg, Emmanuel Deshayes, and Fijs van Leeuwen for their comments during preparation of this letter.

Author information

Author notes

  1. Julie Nonnekens and An Aerts contributed equally to this work.

Authors and Affiliations

  1. Department of Imaging Chemistry and Biology, School of Biomedical Engineering & Imaging Sciences, King’s College London, 4th floor Lambeth Wing, St Thomas’ Hospital, London, SE1 7EH, UK

    Samantha Y. A. Terry

  2. Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, Netherlands

    Julie Nonnekens & Marion de Jong

  3. Department of Molecular Genetics, Erasmus MC, Rotterdam, Netherlands

    Julie Nonnekens

  4. Radiobiology Unit, Interdisciplinary Biosciences, Institute for Environment, Health and Safety, SCK•CEN, Belgian Nuclear Research Centre, Mol, Belgium

    An Aerts & Sarah Baatout

  5. CRUK/MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Old Road Campus Research Building, Off Roosevelt Drive, Oxford, OX3 7LJ, UK

    Bart Cornelissen

  6. IRCM, Institut de Recherche en Cancérologie de Montpellier, F-34298, Montpellier, France

    Jean-Pierre Pouget

  7. INSERM U1194, F-34298, Montpellier, France

    Jean-Pierre Pouget

  8. Université de Montpellier, F-34298, Montpellier, France

    Jean-Pierre Pouget

  9. Institut régional du Cancer de Montpellier, F-34298, Montpellier, France

    Jean-Pierre Pouget

Authors
  1. Samantha Y. A. Terry
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Julie Nonnekens
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. An Aerts
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Sarah Baatout
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Marion de Jong
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Bart Cornelissen
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Jean-Pierre Pouget
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Samantha Y. A. Terry.

Ethics declarations

Conflict of interest

Author ST declares that she has no conflict of interest. Author JN has an investigator-initiated project contract with Advanced Accelerator Applications, a Novartis company. Author AA declares that she has no conflict of interest. Author SB declares that she has no conflict of interest. Author MdJ has an investigator-initiated project contract with Advanced Accelerator Applications, a Novartis company. Author BC is a paid consultant for Molecular Targeted Radiopharmaceuticals. Author J-PP declares that he has no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Terry, S.Y.A., Nonnekens, J., Aerts, A. et al. Call to arms: need for radiobiology in molecular radionuclide therapy. Eur J Nucl Med Mol Imaging 46, 1588–1590 (2019). https://doi.org/10.1007/s00259-019-04334-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00259-019-04334-3

Search

Navigation