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Overview of imaging findings associated with systemic therapies in advanced epithelial ovarian cancer

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Abstract

Purpose

To provide an overview for radiologists of the systemic agents used in the treatment of advanced epithelial ovarian cancer (EOC) and their associated toxicities.

Results

EOC is a common gynecological malignancy, with the majority of patients presenting with advanced stage disease at the time of diagnosis. Although primary cytoreductive surgery and chemotherapy are the principal treatments for EOC, recurrence rates of disease remain high. As several molecular targeted therapies have been developed in the last decade, various novel agents have shown efficacy in the treatment of advanced EOC. Advanced EOC will be discussed by outlining the relevant radiological features of toxicities.

Conclusion

Knowledge of the systemic therapies utilized in the treatment of advanced EOC and their associated radiological features is critical in diagnostic image interpretation.

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Authors and Affiliations

  1. Department of Radiology, University Hospitals Cleveland Medical Center, 11100 Euclid Ave, Cleveland, OH, 44106, USA

    Ezgi Guler, Daniel A. Smith, Nikhil H. Ramaiya & Sree Harsha Tirumani

  2. Department of Radiology, Harvard Medical School, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, USA

    Bhanusupriya Somarouthu

  3. Department of Radiology, Harvard Medical School, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, 02215, USA

    Rahul Gujrathi

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  1. Ezgi Guler
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Guler, E., Smith, D.A., Somarouthu, B. et al. Overview of imaging findings associated with systemic therapies in advanced epithelial ovarian cancer. Abdom Radiol 45, 828–841 (2020). https://doi.org/10.1007/s00261-019-02175-0

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