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Systematic approach for assessment of imaging features in chronic pancreatitis: a feasibility and validation study from the Scandinavian Baltic Pancreatic Club (SBPC) database

  • Special Section: Pancreatitis
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Abstract

Purpose

There is an unmet need for new systems with quantitative pancreatic imaging assessments to support better diagnosis and understand development of chronic pancreatitis (CP). The aims were to present such an approach for assessment of imaging features in CP, to apply this system in a multi-center cohort of CP patients (feasibility study), and to report inter-reader agreement between expert radiologists (validation study).

Methods

The feasibility study included pancreatic computed tomography (CT) or magnetic resonance imaging (MRI) from 496 patients with definitive CP in the Scandinavian Baltic Pancreatic Club (SBPC) database. Images were assessed according to the new SBPC imaging system (quantitative assessments of ductal and parenchymal features). Inter-reader agreement of reported imaging parameters was investigated for 80 CT and 80 MRI examinations by two expert radiologists.

Results

Reporting of the imaging features into the imaging system was deemed feasible for > 80% of CT and > 90% of MRI examinations. Quantitative assessments of main pancreatic duct diameters, presence/number/diameter of calcifications, and gland diameters had high levels of inter-reader agreement with κ-values of 0.75–0.87 and intraclass correlation coefficients of 0.74–0.97. The more subjective assessments, e.g., irregular main pancreatic duct and dilated side-ducts, had poor to moderate agreement with κ-values of 0.03–0.44.

Conclusion

The presented system provides a feasible mean for systematic assessment of CP imaging features. Imaging parameters based on quantitative assessment, as opposed to subjective assessments, have better reproducibility and should be preferred in the development of new grading systems for understanding pathophysiology and disease progression in CP.

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Authors and Affiliations

  1. Department of Radiology, Aalborg University Hospital, P.O. Box 365, 9100, Aalborg, Denmark

    Maria Valeryevna Lisitskaya, Petra Svarc & Jens Brøndum Frøkjær

  2. Department of Clinical Medicine, Aalborg University, Aalborg, Denmark

    Maria Valeryevna Lisitskaya, Søren Schou Olesen, Asbjørn Mohr Drewes & Jens Brøndum Frøkjær

  3. Department of Gastroenterology & Hepatology, Aalborg University Hospital, Aalborg, Denmark

    Søren Schou Olesen & Asbjørn Mohr Drewes

  4. Gastro Unit, Division of Endoscopy, Copenhagen University Hospital Herlev, Copenhagen, Denmark

    Mohamed Ebrahim

  5. Department of Radiology, Hvidovre University Hospital, Copenhagen, Denmark

    Annette Bøjer Jensen

  6. Department of Gastroenterology, Hvidovre University Hospital, Copenhagen, Denmark

    Camilla Nøjgaard

  7. Digestive Diseases Centre, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark

    Peter Nørregaard

  8. Department of Radiology, Mohn Medical Imaging and Visualization Centre, Haukeland University Hospital, Bergen, Norway

    Ingfrid S. Haldorsen

  9. Department of Clinical Medicine, University of Bergen, Bergen, Norway

    Ingfrid S. Haldorsen & Trond Engjom

  10. Department of Medicine, Haukeland University Hospital, Bergen, Norway

    Trond Engjom

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  1. Maria Valeryevna Lisitskaya
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  2. Søren Schou Olesen
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Correspondence to Jens Brøndum Frøkjær.

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Lisitskaya, M.V., Olesen, S.S., Svarc, P. et al. Systematic approach for assessment of imaging features in chronic pancreatitis: a feasibility and validation study from the Scandinavian Baltic Pancreatic Club (SBPC) database. Abdom Radiol 45, 1468–1480 (2020). https://doi.org/10.1007/s00261-020-02466-x

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