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Observational study and brief analysis of diagnostic criteria in relapsing polychondritis

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Abstract

Observational study of patients with relapsing polychondritis (RPC) and brief evaluation of widely used diagnostic criteria. A retrospective analysis of 18 patients with RPC treated in the past 15 years at the Charté—Universitätsmedizin Berlin was performed. Three different diagnostic criteria were applied to our cohort. Sensitivities of diagnostic criteria of McAdam et al., Damiani and Levine and Michet et al. were calculated as well as the 5- and 10-year survival. Analysis of diagnostic criteria revealed a sensitivity of 88.9% using Damiani and Levine criteria, 66.7% for Michet et al. and 50% for McAdam et al., respectively. Modifying the criteria of Michet et al. increases the sensitivity to 88.9%. The 5- and 10-year survival were 100 and 90.9%, respectively. Current diagnostic criteria in RPC should be reappraised covering the diversity of clinical findings with the aim to improve clinical care and research in RPC.

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References

  1. Mathian A, Miyara M, Cohen-Aubart F et al (2016) Relapsing polychondritis: a 2016 update on clinical features, diagnostic tools, treatment and biological drug use. Best Pract Res Clin Rheumatol 30:316–333. https://doi.org/10.1016/j.berh.2016.08.001

    Article  PubMed  Google Scholar 

  2. Lekpa FK, Chevalier X (2018) Refractory relapsing polychondritis: challenges and solutions. In: Open Access Rheumatol. Res. Rev. https://www.dovepress.com/refractory-relapsing-polychondritis-challenges-and-solutions-peer-reviewed-fulltext-article-OARRR. Accessed 20 Mar 2018

  3. Arnaud L, Mathian A, Haroche J et al (2014) Pathogenesis of relapsing polychondritis: a 2013 update. Autoimmun Rev 13:90–95. https://doi.org/10.1016/j.autrev.2013.07.005

    Article  CAS  PubMed  Google Scholar 

  4. FrancèS C, El Rassi R, Laporte JL et al (2001) Dermatologic manifestations of relapsing polychondritis: a study of 200 cases at a single center. Medicine (Baltimore) 80:173–179. https://doi.org/10.1097/00005792-200105000-00003

    Article  Google Scholar 

  5. Michet CJ (1986) Relapsing polychondritis: survival and predictive role of early disease manifestations. Ann Intern Med 104:74. https://doi.org/10.7326/0003-4819-104-1-74

    Article  PubMed  Google Scholar 

  6. McAdam LP, O’Hanlan MA, Bluestone R, Pearson CM (1976) Relapsing polychondritis: prospective study of 23 patients and a review of the literature. Medicine (Baltimore) 55:193–215

    Article  CAS  Google Scholar 

  7. Buckley LM, Ades PA Progressive aortic valve inflammation occurring despite apparent remission of relapsing polychondritis. Arthritis Rheum 35:812–814. https://doi.org/10.1002/art.1780350716

    Article  CAS  Google Scholar 

  8. Cipriano PR, Alonso DR, Baltaxe HA et al (1976) Multiple aortic aneurysms in relapsing polychondritis. Am J Cardiol 37:1097–1102

    Article  CAS  Google Scholar 

  9. Dion Jérémie Costedoat-Chalumeau, Nathalie S, Damien et al (2016) Relapsing polychondritis can be characterized by three different clinical phenotypes: analysis of a recent series of 142 patients. Arthritis Rheumatol 68:2992–3001. https://doi.org/10.1002/art.39790

    Article  PubMed  Google Scholar 

  10. Moulis G, Pugnet G, Costedoat-Chalumeau N et al (2018) Efficacy and safety of biologics in relapsing polychondritis: a French national multicentre study. Ann Rheum Dis. https://doi.org/10.1136/annrheumdis-2017-212705

    Article  PubMed  Google Scholar 

  11. Kemta Lekpa F, Kraus VB, Chevalier X (2012) Biologics in relapsing polychondritis: a literature review. Semin Arthritis Rheum 41:712–719. https://doi.org/10.1016/j.semarthrit.2011.08.006

    Article  PubMed  Google Scholar 

  12. Cantarini L, Vitale A, Brizi MG et al (2014) Diagnosis and classification of relapsing polychondritis. J Autoimmun 48–49:53–59. https://doi.org/10.1016/j.jaut.2014.01.026

    Article  CAS  PubMed  Google Scholar 

  13. Damiani JM, Levine HL (1979) Relapsing polychondritis–report of ten cases. Laryngoscope 89:929–946

    Article  CAS  Google Scholar 

  14. Trentham DE (1998) Relapsing polychondritis. Ann Intern Med 129:114. https://doi.org/10.7326/0003-4819-129-2-199807150-00011

    Article  CAS  PubMed  Google Scholar 

  15. Mathew SD, Battafarano DF, Morris MJ (2012) Relapsing polychondritis in the department of defense population and review of the literature. Semin Arthritis Rheum 42:70–83. https://doi.org/10.1016/j.semarthrit.2011.12.007

    Article  PubMed  Google Scholar 

  16. Zeuner M, Straub RH, Rauh G et al (1997) Relapsing polychondritis: clinical and immunogenetic analysis of 62 patients. J Rheumatol 24:96–101

    CAS  PubMed  Google Scholar 

  17. PIETTE J, EL-RASSI R, AMOURA Z (1999) Antinuclear antibodies in relapsing polychondritis. Ann Rheum Dis 58:656–657

    Article  CAS  Google Scholar 

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Acknowledgements

The authors thank Anna R. Lisney for proof-reading of the manuscript.

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Authors and Affiliations

  1. Department of Rheumatology and Clinical Immunology, Charité Universitätsmedizin Berlin, Chariteplatz 1, 10117, Berlin, Germany

    Thomas Rose, Udo Schneider, Vincent Casteleyn, Robert Biesen, Gerd R. Burmester & Falk Hiepe

  2. Department of Nephrology, Charité Universitätsmedizin Berlin, Chariteplatz 1, 10117, Berlin, Germany

    Martina Bertolo

  3. German Rheumatism Research Center, Berlin-Leibniz Institute, 10117, Berlin, Germany

    Jens Klotsche

Authors
  1. Thomas Rose
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  2. Udo Schneider
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  3. Martina Bertolo
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  4. Jens Klotsche
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  5. Vincent Casteleyn
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  6. Robert Biesen
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  7. Gerd R. Burmester
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  8. Falk Hiepe
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Correspondence to Thomas Rose.

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All authors have no financial or competing interests to declare. We received no financial support or other benefits from commercial sources for the reported work on the manuscript.

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Rose, T., Schneider, U., Bertolo, M. et al. Observational study and brief analysis of diagnostic criteria in relapsing polychondritis. Rheumatol Int 38, 2095–2101 (2018). https://doi.org/10.1007/s00296-018-4121-2

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  • DOI: https://doi.org/10.1007/s00296-018-4121-2

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