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Prediction of axillary response by monitoring with ultrasound and MRI during and after neoadjuvant chemotherapy in breast cancer patients

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Abstract

Purpose

To investigate whether monitoring with ultrasound and MR imaging before, during and after neoadjuvant chemotherapy (NAC) can predict axillary response in breast cancer patients.

Materials and methods

A total of 131 breast cancer patients with clinically positive axillary lymph node (LN) who underwent NAC and subsequent surgery were enrolled. They had ultrasound and 3.0 T-MR examinations before, during and after NAC. After reviewing ultrasound and MR images, axillary LN features and tumour size (T size) were noted. According to LN status after surgery, imaging features and their diagnostic performances were analysed.

Results

Of the 131 patients, 60 (45.8%) had positive LNs after surgery. Pre-NAC T size at ultrasound and MR was different in positive LN status after surgery (p < 0.01). There were significant differences in mid- and post-NAC number, cortical thickness (CxT), T size and T size reduction at ultrasound and mid- and post-NAC CxT, hilum, T size and T size reduction, and post-NAC ratio of diameter at MR (p < 0.03). On multivariate analysis, pre-NAC MR T size (OR, 1.03), mid-NAC ultrasound T size (OR, 1.05) and CxT (OR, 1.53), and post-NAC MR T size (OR, 1.06) and CxT (OR, 1.64) were independently associated with positive LN (p < 0.004). Combined mid-NAC ultrasound T size and CxT showed the best diagnostic performance with AUC of 0.760.

Conclusion

Monitoring ultrasound and MR axillary LNs and T size can be useful to predict axillary response to NAC in breast cancer patients.

Key Points

• Monitoring morphologic features of LNs is useful to predict axillary response.

• Monitoring tumour size by imaging is useful to predict axillary response.

• The axillary ultrasound during NAC showed the highest diagnostic performance.

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Abbreviations

ALND:

Axillary lymph node dissection

AUC:

The area under the receiver operating characteristic curve

ER:

Oestrogen receptor

HER2:

Human epidermal growth factor receptor 2

IHC:

Immunohistochemistry

LN:

Lymph node

NAC:

Neoadjuvant chemotherapy

NPV:

Negative predictive value

pCR:

Pathologic complete response

PR:

Progesterone receptor

SLNB:

Sentinel lymph node biopsy

US:

Ultrasound

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Funding

The authors state that this work has not received any funding.

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Authors and Affiliations

  1. Department of Radiology, Gangnam Severance Hospital, Yonsei University College of Medicine, 211 Eonju-ro, Gangnam-gu, Seoul, 06273, South Korea

    Na Lae Eun, Eun Ju Son, Hye Mi Gweon, Jeong-Ah Kim & Ji Hyun Youk

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  1. Na Lae Eun
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  2. Eun Ju Son
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  3. Hye Mi Gweon
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  5. Ji Hyun Youk
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Correspondence to Ji Hyun Youk.

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Guarantor

The scientific guarantor of this publication is Professor Ji Hyun Youk, MD, PhD, at Yonsei University College of Medicine.

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The authors declare that they have no competing interests.

Statistics and biometry

No complex statistical methods were necessary for this paper.

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Written informed consent was waived by the Institutional Review Board.

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Methodology

• Retrospective

• Diagnostic or prognostic study

• Performed at one institution

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Eun, N.L., Son, E.J., Gweon, H.M. et al. Prediction of axillary response by monitoring with ultrasound and MRI during and after neoadjuvant chemotherapy in breast cancer patients. Eur Radiol 30, 1460–1469 (2020). https://doi.org/10.1007/s00330-019-06539-4

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  • DOI: https://doi.org/10.1007/s00330-019-06539-4

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