Skip to main content

Advertisement

SpringerLink
Log in

Lines under the eyes: a large prospective case series of linear basal cell carcinomas

  • Short Report
  • Published:
Archives of Dermatological Research Aims and scope Submit manuscript

Abstract

Basal cell carcinomas (BCC) are the most common form of cancer globally. Linear BCCs are an unusual variant which are generally defined by having a length three times longer than the width and exhibiting relatively straight edges. In this report, we describe the largest global cohort (n = 31) with this rare subtype. Within this cohort, 22 were in the periocular region, 27 underwent Mohs micrographic surgery and 12 involved oculoplastic reconstruction. These results suggest that, whilst this subtype is relatively rare, it may be more prevalent than previously thought. Dermatologists and other specialities managing skin cancer, particularly ophthalmologists, should, therefore, be aware of this subtype, as it is often more aggressive than other BCC subtypes, often requiring multi-disciplinary management.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Abbreviations

BCC:

Basal cell carcinoma

MMS:

Mohs micrographic surgery

UK:

United Kingdom

References

  1. Reinau D, Surber C, Jick SS, Meier CR (2014) Epidemiology of basal cell carcinoma in the United Kingdom: incidence, lifestyle factors, and comorbidities. Br J Cancer. https://doi.org/10.1038/bjc.2014.265

    Article  PubMed  PubMed Central  Google Scholar 

  2. Peterson SC, Eberl M, Vagnozzi AN, Belkadi A, Veniaminova NA, Verhaegen ME et al (2015) Basal cell carcinoma preferentially arises from stem cells within hair follicle and mechanosensory niches. Cell Stem Cell. https://doi.org/10.1016/j.stem.2015.02.006

    Article  PubMed  PubMed Central  Google Scholar 

  3. Grachtchouk M, Pero J, Yang SH, Ermilov AN, Michael LE, Wang A et al (2011) Basal cell carcinomas in mice arise from hair follicle stem cells and multiple epithelial progenitor populations. J Clin Invest. https://doi.org/10.1172/JCI46307

    Article  PubMed  PubMed Central  Google Scholar 

  4. Dourmishev L, Rusinova D, Botev I (2013) Clinical variants, stages, and management of basal cell carcinoma. Indian Dermatol Online J. https://doi.org/10.4103/2229-5178.105456

    Article  PubMed  PubMed Central  Google Scholar 

  5. Lewis JE (1985) Linear basal cell epithelioma. Int J Dermatol. https://doi.org/10.1111/j.1365-4362.1985.tb05396.x

    Article  PubMed  Google Scholar 

  6. Al-Niaimi F, Lyon CC (2011) Linear basal cell carcinoma: a distinct condition? Clin Exp Dermatol. https://doi.org/10.1111/j.1365-2230.2010.03908.x

    Article  PubMed  Google Scholar 

  7. Lim KK, Randle HW, Roenigk RK, Brodland DG, Bernstein SC, Marcil I (1999) Linear basal cell carcinoma: report of seventeen cases and review of the presentation and treatment. Dermatologic Surg. https://doi.org/10.1046/j.1524-4725.1999.08104.x

    Article  Google Scholar 

  8. Hussain W, Affleck A, Al-Niaimi F, Cooper A, Craythorne E, Fleming C et al (2017) Safety, complications and patients’ acceptance of Mohs micrographic surgery under local anaesthesia: results from the U.K. MAPS (Mohs Acceptance and Patient Safety) Collaboration Group. Br J Dermatol. https://doi.org/10.1111/bjd.14843

    Article  PubMed  Google Scholar 

  9. Brailey LL, Davis T, Kolker SE, Murry TC, Thomas D, Bale AE et al (2007) Congenital linear unilateral basal cell nevus: a case report with patched gene molecular studies. J Cutan Pathol 34(1):65–70

    Article  CAS  PubMed  Google Scholar 

  10. Ward JM, Russell M (2019) Recurrence of linear basal cell carcinoma. Cutis 104:114

    PubMed  Google Scholar 

  11. Peschen M, Lo JS, Snow SN, Mohs FE (1993) Linear basal cell carcinoma. Cutis 51:287

    CAS  PubMed  Google Scholar 

  12. Noodleman FR, Pollack SV (1986) Trauma as a possible etiologic factor in basal cell carcinoma. J Dermatol Surg Oncol. https://doi.org/10.1111/j.1524-4725.1986.tb01991.x

    Article  PubMed  Google Scholar 

  13. Sekulic A, Migden MR, Basset-Seguin N, Garbe C, Gesierich A, Lao CD et al (2017) Long-term safety and efficacy of vismodegib in patients with advanced basal cell carcinoma: final update of the pivotal ERIVANCE BCC study. BMC Cancer 17(1):332. https://doi.org/10.1186/s12885-017-3286-5

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Frakulli R, Galuppi A, Cammelli S, Macchia G, Cima S, Gambacorta MA et al (2015) Brachytherapy in non melanoma skin cancer of eyelid: a systematic review. J Contemp Brachytherapy 7(6):497–502. https://doi.org/10.5114/jcb.2015.56465

    Article  PubMed  PubMed Central  Google Scholar 

  15. Rutkowski D, Littlewood Z, Touyz SJJ, Collier NJ, Madan V, Ghura HS et al (2022) Prevalence of wound complications following Mohs micrographic surgery (MMS): a cross-sectional study of 1000 patients undergoing MMS and wound repair in a UK teaching hospital. Clin Exp Dermatol. https://doi.org/10.1111/ced.15226

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Mohs Unit, Department of Dermatology, Salford Royal Hospital NHS Foundation Trust, Northern Care Alliance NHS Group, Salford, England

    D. Rutkowski, N. J. Collier, N. Telfer & V. Ghura

  2. Dermatology Research Centre, NIHR Biomedical Research Centre, University of Manchester, Manchester, UK

    D. Rutkowski & N. J. Collier

Authors
  1. D. Rutkowski
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. N. J. Collier
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. N. Telfer
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. V. Ghura
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

"All authors contributed and reviewed the manuscript."

Corresponding author

Correspondence to D. Rutkowski.

Ethics declarations

Conflict of interest

None declared.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Rutkowski, D., Collier, N.J., Telfer, N. et al. Lines under the eyes: a large prospective case series of linear basal cell carcinomas. Arch Dermatol Res 315, 621–624 (2023). https://doi.org/10.1007/s00403-022-02385-5

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00403-022-02385-5

Search

Navigation