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Impact of FAAH genetic variation on fronto-amygdala function during emotional processing

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Abstract

Recent translational studies identified a common endocannabinoid polymorphism, FAAH C385A, in the gene for the fatty acid amide hydrolase (FAAH). This polymorphism alters endocannabinoid anandamide levels, which are known to be involved in the fronto-amygdala circuitry implicated in mood regulation and anxiety-like behaviors. While it has been shown that the variant that selectively enhances fronto-amygdala connectivity at rest is associated with decreased anxiety-like behaviors, no study so far has investigated whether this finding of FAAH-related differential plasticity extends to task-related differential functional expression and regulation during negative emotional processing. Using an imaging genetics approach, this study aimed to replicate and extend prior findings by examining functional activity and task-related connectivity in fronto-amygdala regions during emotion reactivity and emotional down-regulation of negative affect. Therefore, 48 healthy young adults underwent a functional MRI resting state measurement, completed an emotion regulation paradigm and provided self-reports on anxiety and use of emotion regulation strategies. In line with previous studies, preliminary evidence suggests that A-allele carriers demonstrate stronger fronto-amygdala connectivity during rest. In addition, exploratory whole-brain analyses indicate differential functional activity of A-allele carriers during emotion reactivity and emotion regulation. There were no associations with anxiety-related self-reports and use of emotional regulation strategies. Further research using larger samples and polygenic approaches is indicated to clarify the precise role and its underlying mechanisms in emotion processing.

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Acknowledgements

This research was funded by the Deutsche Forschungsgemeinschaft (SFB 940, project A5) to AS, KD and BB. We thank Fanny Weber-Göricke for her valuable help in data acquisition.

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Authors and Affiliations

  1. Faculty of Psychology, Technische Universität Dresden, Dresden, Germany

    Anne Gärtner, Denise Dörfel, Kersten Diers, Alexander Strobel & Burkhard Brocke

  2. Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany

    Stephanie H. Witt

Authors
  1. Anne Gärtner
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  2. Denise Dörfel
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  3. Kersten Diers
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  4. Stephanie H. Witt
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  5. Alexander Strobel
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  6. Burkhard Brocke
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Contributions

AG, KD, BB and AS designed the research; KD performed the measurements; AG and KD conducted the analyses; SHW was responsible for DNA extraction and genotyping; AG, DD, BB, AS and SHW wrote the paper. The final version of the paper was approved by all authors.

Corresponding author

Correspondence to Anne Gärtner.

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None of the authors has a conflict of interest to declare.

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Gärtner, A., Dörfel, D., Diers, K. et al. Impact of FAAH genetic variation on fronto-amygdala function during emotional processing. Eur Arch Psychiatry Clin Neurosci 269, 209–221 (2019). https://doi.org/10.1007/s00406-018-0944-9

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  • DOI: https://doi.org/10.1007/s00406-018-0944-9

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