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2017 revisions of McDonald criteria shorten the time to diagnosis of multiple sclerosis in clinically isolated syndromes

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Abstract

Objectives

To investigate the impact of the 2017 revisions of McDonald criteria on the diagnosis of multiple sclerosis (MS) in a cohort of patients with clinically isolated syndrome (CIS) and dissemination in space (DIS) of demyelinating lesions.

Methods

We retrospectively analyzed 137 patients with CIS + DIS from two Italian MS centers.

Results

Application of the 2017 revisions of McDonald criteria in our cohort led to a diagnosis of MS in 82.5% of the patients who could have not been diagnosed with MS according to the previous criteria at the time of the first demyelinating event. After a follow-up of 3.8 ± 2.9 years, 85.8% of these patients eventually satisfied also the previous (2010) criteria.

Conclusions

Application of the 2017 revisions of McDonald criteria results in an earlier diagnosis of MS in a large percentage of CIS patients destined to convert to MS.

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Authors and Affiliations

  1. Clinica Neurologica, Dipartimento di Medicina, Ospedale S. Maria della Misericordia, Università degli Studi di Perugia, 06156, Perugia, Italy

    Lorenzo Gaetani, Andrea Mancini, Paolo Eusebi, Maria Chiara Cerri, Paolo Calabresi, Paola Sarchielli & Massimiliano Di Filippo

  2. Department of Neurology and Psychiatry, Sapienza University, Rome, Italy

    Luca Prosperini & Carlo Pozzilli

  3. Department of Neurosciences, S. Camillo-Forlanini Hospital, Rome, Italy

    Luca Prosperini

  4. IRCCS Fondazione Santa Lucia, Rome, Italy

    Paolo Calabresi

Authors
  1. Lorenzo Gaetani
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  2. Luca Prosperini
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  3. Andrea Mancini
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  4. Paolo Eusebi
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  5. Maria Chiara Cerri
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  6. Carlo Pozzilli
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  7. Paolo Calabresi
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  8. Paola Sarchielli
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  9. Massimiliano Di Filippo
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Corresponding author

Correspondence to Massimiliano Di Filippo.

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Conflicts of interest

LG received travel grants from Biogen, Novartis, Teva, Sanofi Genzyme and Almirall to attend national and international conferences. LP has received research grant from Associazione Italiana Sclerosi Multipla (AISM) and Genzyme; consulting and/or lecture fees and travel grants from Biogen, Genzyme, Novartis and Teva. AM received travel grants from Teva and Sanofi Genzyme to attend national conferences. CP has received consulting and/or lecture fees and/or research funding and travel grant from Almirall, Bayer Schering, Biogen Idec, Genzyme, Merck Serono, Novartis, Roche and Teva. PC received/receive research support from Bayer Schering, Biogen-Dompé, Boehringer Ingelheim, Eisai, Lundbeck, Merck-Serono, Novartis, Sanofi-Aventis, Sigma-Tau, and UCB Pharma. MDF participated to advisory boards and received speaker/writing honoraria and funding for traveling from: Bayer, Biogen Idec, Genzyme, Merck, Novartis, Roche and Teva. PE, PS, MCC report no conflicts of interests.

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Gaetani, L., Prosperini, L., Mancini, A. et al. 2017 revisions of McDonald criteria shorten the time to diagnosis of multiple sclerosis in clinically isolated syndromes. J Neurol 265, 2684–2687 (2018). https://doi.org/10.1007/s00415-018-9048-8

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  • DOI: https://doi.org/10.1007/s00415-018-9048-8

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