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The role of dietary phytochemicals in the carcinogenesis via the modulation of miRNA expression

  • Review – Cancer Research
  • Published:
Journal of Cancer Research and Clinical Oncology Aims and scope Submit manuscript

Abstract

Purpose

Phytochemicals are naturally occurring plant-derived compounds and some of them have the potential to serve as anticancer drugs. Based on recent evidence, aberrantly regulated expression of microRNAs (miRNAs) is closely associated with malignancy. MicroRNAs are characterized as small non-coding RNAs functioning as posttranscriptional regulators of gene expression. Accordingly, miRNAs regulate various target genes, some of which are involved in the process of carcinogenesis.

Results

This comprehensive review emphasizes the anticancer potential of phytochemicals, either isolated or in combination, mediated by miRNAs. The ability to modulate the expression of miRNAs demonstrates their importance as regulators of tumorigenesis. Phytochemicals as anticancer agents targeting miRNAs are widely studied in preclinical in vitro and in vivo research. Unfortunately, their anticancer efficacy in targeting miRNAs is less investigated in clinical research.

Conclusions

Significant anticancer properties of phytochemicals as regulators of miRNA expression have been proven, but more studies investigating their clinical relevance are needed.

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Funding

This work was supported by the Scientific Grant Agency of the Ministry of Education of the Slovak Republic under the contracts no. VEGA 1/0136/19, 1/0124/17 and the Slovak Research and Development Agency under the contract no. APVV-16-0021. This publication is the result of the projects implementation: “Center of Excellence of Perinatology Reseach (CEPV II)”, ITMS: 26220120036 supported by the Operational Programme Research and Innovation funded by the ERDF and “Molecular diagnosis of cervical cancer”, ITMS: 26220220113 supported by the Operational Programme Research and Innovation funded by the ERDF. This work was supported by Government of Russian Federation Grant 08-08.

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Authors and Affiliations

  1. Clinic of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia

    Marek Samec, Alena Liskova, Pavol Zubor, Tibor Bielik, Kamil Biringer & Erik Kudela

  2. Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Mala Hora 4, 03601, Martin, Slovak Republic

    Peter Kubatka & Martin Pec

  3. Division of Oncology, Department of Experimental Carcinogenesis, Jessenius Faculty of Medicine, Biomedical Center Martin, Comenius University in Bratislava, Martin, Slovakia

    Peter Kubatka & Sona Uramova

  4. Department of Physiology and Biophysics, Weill Cornell Medicine-Qatar, Education City, Qatar Foundation, P.O. Box 24144, Doha, Qatar

    Samson Mathews Samuel & Dietrich Büsselberg

  5. Institute for Health and Sport, Victoria University, Melbourne, Australia

    Anthony Zulli

  6. Faculty of Health Science and Social Work, Trnava University, Trnava, Slovakia

    Jozef Benacka

  7. Department of Thoracic Surgery, Faculty of Medicine and Dentistry, Medical University of Silesia, Katowice, Poland

    Mariusz Adamek

  8. Faculty of Medicine, Central University Hospital of Asturias (HUCA), University of Oviedo, Oviedo, Spain

    Luis Rodrigo

  9. Gastroenterology Unit, Department of Medicine, AOUI Policlinico G.B. Rossi, University of Verona, Verona, Italy

    Rachele Ciccocioppo

  10. Department of Immunology, School of Medicine, Keimyung University, Dalseo-Gu, Daegu, Korea

    Taeg Kyu Kwon

  11. International Research Centre “Biotechnologies of the Third Millennium”, ITMO University, Saint-Petersburg, Russian Federation

    Denis Baranenko

  12. 2nd Department of Surgery, Faculty of Medicine, Masaryk University and St. Anne’s University Hospital, Brno, Czech Republic

    Peter Kruzliak

  13. Department of Internal Medicine, Brothers of Mercy Hospital, Polni 553/3, 63900, Brno, Czech Republic

    Peter Kruzliak

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  1. Marek Samec
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  2. Alena Liskova
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Samec, M., Liskova, A., Kubatka, P. et al. The role of dietary phytochemicals in the carcinogenesis via the modulation of miRNA expression. J Cancer Res Clin Oncol 145, 1665–1679 (2019). https://doi.org/10.1007/s00432-019-02940-0

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