Abstract
Ferrets (Mustela putorius furo) are becoming increasingly popular as pets and are kept in households with other pet animals such as dogs and cats, from which they may catch flea infestations with the predominant flea species Ctenocephalides felis. In this study, the efficacy of imidacloprid/moxidectin spot-on (Advocate®/Advantage Multi™) was investigated in the therapy and prevention of flea infestation in ferrets. Sixteen adult ferrets of varying weights and ages and of both sexes were included. Ferrets were infested with 50 fleas each on days −7, −1, 7, 14, 21, and 28. On study day −6, the animals were randomized into two groups based on body weight and flea count. Each ferret allocated to group 1 was treated with 0.4 ml of imidacloprid 10%/moxidectin 1% (Advocate®/Advantage Multi™). The ferrets in group 2 remained untreated. Flea counts were performed by combing 24 to 48 h after infestation. The primary efficacy criterion was the reduction in the number of fleas at each time point post treatment compared to the ferrets in the untreated control group. On day 1, the therapeutic efficacy was 100%. The preventative efficacy was 100% at 1 and 2 weeks post treatment, and it was >97% and >90% at 3 and 4 weeks post treatment. No local or systemic side effects were observed in any of the ferrets treated.
References
Altreuther G (2001) Serum pharmacokinetics of imidacloprid 10%/moxidectin 1% spot-on in cats during four topical applications at monthly intervals. Bayer report ID 24954
Anonymous (2000) Guideline for good clinical practice, EMEA/CVMP/VICH/595/98-final, July 4, 2000, effective July 2001
Anonymous (2006) Guidelines for testing and evaluation of the efficacy of antiparasitic substances for the treatment and prevention of tick and flea infestation in dogs and cats, EMEA/CVMP/EWP/2000-Rev. 2, effective June 1, 2008
Beck W (2007) Ectoparasites, endoparasites and heartworm control in small animals. Compendium of Continuing Education for Veterinarians 29:3–8.
Beddies G, Krebber R (2001) Serum pharmacokinetics of imidacloprid 10%/moxidectin 2.5% spot-on in dogs applied once per month for three consecutive intervals. Bayer report ID 24953
Fox JG (1988) Biology and diseases of the ferret. Lea & Febiger, Philadelphia, pp 242–245
Hutchinson MJ, Jacobs DE, Mencke N (2001) Establishment of the cat flea (Ctenocephalides felis felis) on the ferret (Mustela putorius furo) and its control with imidacloprid. Med Vet Entomol 15:212–214
Krämer F, Mencke N (2001) Flea biology and control: the biology of the cat flea, control and prevention with imidacloprid in small animals. Springer, Berlin
Larsen KS, Sigurdsson H, Mencke N (2005) Efficacy of imidacloprid, imidacloprid/permethrin and phoxim for flea control in the mustelidae (ferret, mink). Parasitol Res 97(Supplement 1):107–112
Liebisch A, Liebisch G (1999) Flohbefall. In: Wiesner E (ed) Handlexikon der Tierärtzlichen Praxis. Enke-Verlag, Stuttgart, pp 271–271j
Oxenham M (1996) Flea control in ferrets. Vet Rec 138:372
Rupprecht CE, Gilbert J, Pitts R, Marshall KR, Koprowsky H (1990) Evaluation of an inactivated rabies virus vaccine in domestic ferrets. J Am Vet Med Assoc 196:1614–1616
Schaper R (2008) Market research on ferret figures in European countries. Bayer report ID 29853
Timm KI (1988) Pruritus in rabbits, rodents and ferrets. Vet Clin North Am, Small Anim Pract 18:1077–1091
Visser M, Rehbein D, Wiedemann C (2001) Species of flea (Siphonaptera) infesting pets and hedgehogs in Germany. J Vet Med B 48:197–202
Wenzel U, Arnold P (1983) Flohbefunde bei kleinen Haus- und Pelztieren. Kleintiertagung, Magdeburg 1983
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Wenzel, U., Heine, J., Mengel, H. et al. Efficacy of imidacloprid 10%/moxidectin 1% (Advocate®/Advantage Multi™) against fleas (Ctenocephalides felis felis) on ferrets (Mustela putorius furo). Parasitol Res 103, 231–234 (2008). https://doi.org/10.1007/s00436-008-0955-y
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DOI: https://doi.org/10.1007/s00436-008-0955-y