Zusammenfassung
Wir berichten über einen Fall einer ausgeprägten, chronifizierten Lumboischialgie, die sich unter konventioneller Therapie nicht zufriedenstellend schmerztherapeutisch einstellen ließ. Es werden der Schmerzverlauf unter hoch dosierter Dronabinoltherapie mit oraler und inhalativer Applikation sowie der Weg zur Kostenübernahme für Medizinalcannabisblüten, deren Therapieerfolg und Kriterien der wirtschaftlichen Verordnungsweise dargestellt.
Abstract
This article reports a case of pronounced, chronic lumboischialgia, which was not satisfactorily controlled by conventional analgesic treatment. The level of pain under high-dose dronabinol treatment with oral and inhalative administration as well as the way to reimburse the cost of medicinal cannabis flowers, the treatment success and criteria of the economic prescription procedure are presented.
Literatur
Abrams DI, Couey P, Shade SB et al (2011) Cannabinoid–opioid interaction in chronic pain. Clin Pharmacol Ther 90:844–851. https://doi.org/10.1038/clpt.2011.188
Azad SC, Huge V, Schöps P et al (2005) Endogenes Cannabinoidsystem: Einfluss auf neuronale Plastizität und Schmerzgedächtnis. Schmerz 19:521–527. https://doi.org/10.1007/s00482-004-0342-2
Azad SC, Zieglgänsberger W (2003) Was wissen wir über die Chronifizierung von Schmerz? Schmerz 17:441–444. https://doi.org/10.1007/s00482-003-0257-3
Barrie N, Manolios N (2017) The endocannabinoid system in pain and inflammation: Its relevance to rheumatic disease. Eur J Rheumatol 4:210–218. https://doi.org/10.5152/eurjrheum.2017.17025
Brenneisen R, Egli A, Elsohly MA et al (1996) The effect of orally and rectally administered delta 9‑tetrahydrocannabinol on spasticity: A pilot study with 2 patients. Int J Clin Pharmacol Ther 34:446–452
Chhatwal JP, Ressler KJ (2007) Modulation of fear and anxiety by the endogenous cannabinoid system. CNS Spectr 12:211–220
ElSohly MA, Stanford DF, Harland EC et al (1991) Rectal bioavailability of delta-9-tetrahydrocannabinol from the hemisuccinate ester in monkeys. J Pharm Sci 80:942–945
Frondini C, Lanfranchi G, Minardi M, Cucinotta D (2007) Affective, behavior and cognitive disorders in the elderly with chronic musculoskelatal pain: The impact on an aging population. Arch Gerontol Geriatr 44:167–171. https://doi.org/10.1016/j.archger.2007.01.024
Grotenhermen F, Müller-Vahl K (2012) The therapeutic potential of cannabis and cannabinoids. Dtsch Arztebl Int. https://doi.org/10.3238/arztebl.2012.0495
Grotenhermen F, Russo E (2002) Effects of cannabis and cannabinoids. In: Grotenhermen F, Russo E (Hrsg) Cannabis and cannabinoids: Pharmacology, toxicology, and therapeutic potential. Haworth Integrative Healing Press, New York, S 60
Han BH, Sherman SE, Palamar JJ (2019) Prescription opioid misuse among middle-aged and older adults in the United States, 2015–2016. Prev Med 121:94–98. https://doi.org/10.1016/j.ypmed.2019.02.018
Häuser W, Finn DP, Kalso E et al (2018) European Pain Federation (EFIC) position paper on appropriate use of cannabis-based medicines and medical cannabis for chronic pain management. Eur J Pain 22:1547–1564. https://doi.org/10.1002/ejp.1297
Koch HJ (2017) Effective intermittent administration of nabiximols in a patient with autism (Asperger’s syndrome). Acta Med Median 56:102–104. https://doi.org/10.5633/amm.2017.0215
Herdegen T, Horlemann J, Hornke I et al (2018) Expertenkonsens – Medizinischer Einsatz von Cannabinoiden. Lehre Prax 9:16
Huestis MA (2005) Pharmacokinetics and metabolism of the plant cannabinoids, ∆9-tetrahydrocannibinol, cannabidiol and cannabinol. In: Pertwee RG (Hrsg) Cannabinoids. Springer, Berlin, Heidelberg, S 657–690
Huestis MA (2007) Human cannabinoid pharmacokinetics. Chem Biodivers 4:1770–1804. https://doi.org/10.1002/cbdv.200790152
Kathmann M, Flau K, Redmer A et al (2006) Cannabidiol is an allosteric modulator at mu- and delta-opioid receptors. Naunyn Schmiedebergs Arch Pharmacol 372:354–361. https://doi.org/10.1007/s00210-006-0033-x
Lehnhardt F‑G, Gawronski A, Pfeiffer K et al (2013) The investigation and differential diagnosis of Asperger syndrome in adults. Dtsch Arztebl Int. https://doi.org/10.3238/arztebl.2013.0755
Leinwand KL, Gerich ME, Hoffenberg EJ, Collins CB (2017) Manipulation of the endocannabinoid system in colitis: A comprehensive review. Inflamm Bowel Dis 23:192–199. https://doi.org/10.1097/MIB.0000000000001004
Lindberg BW (2018) Policy series: The opioid epidemic and older adults: Pathways to elder abuse and justice. Innov Aging 2:433–434. https://doi.org/10.1093/geroni/igy023.1625
Lowin T, Straub RH (2015) Cannabinoid-based drugs targeting CB1 and TRPV1, the sympathetic nervous system, and arthritis. Arthritis Res Ther. https://doi.org/10.1186/s13075-015-0743-x
Lucas P (2012) Cannabis as an adjunct to or substitute for opiates in the treatment of chronic pain. J Psychoactive Drugs 44:125–133. https://doi.org/10.1080/02791072.2012.684624
Mechoulam R, Ben-Shabat S (1999) From gan-zi-gun-nu to anandamide and 2‑arachidonoylglycerol: The ongoing story of cannabis. Nat Prod Rep 16:131–143
Muller C, Morales P, Reggio PH (2019) Cannabinoid ligands targeting TRP channels. Front Mol Neurosci. https://doi.org/10.3389/fnmol.2018.00487
Nielsen S, Sabioni P, Trigo JM et al (2017) Opioid-sparing effect of cannabinoids: A systematic review and meta-analysis. Neuropsychopharmacology 42:1752–1765. https://doi.org/10.1038/npp.2017.51
Owens B (2015) Drug development: The treasure chest. Nature 525:S6–S8. https://doi.org/10.1038/525S6a
Remesic M, Hruby VJ, Porreca F, Lee YS (2017) Recent advances in the realm of allosteric modulators for opioid receptors for future therapeutics. Acs Chem Neurosci 8:1147–1158. https://doi.org/10.1021/acschemneuro.7b00090
Richardson JD, Aanonsen L, Hargreaves KM (1998) Hypoactivity of the spinal cannabinoid system results in NMDA-dependent hyperalgesia. J Neurosci 18:451–457
Russo EB (2001) The role of cannabis and cannabinoids in pain management. In: Weiner RS (Hrsg) Pain management: A practical guide for clinicians, 6. Aufl. CRC, Boca Raton, S 357–375
Russo EB (2011) Taming THC: Potential cannabis synergy and phytocannabinoid-terpenoid entourage effects: Phytocannabinoid-terpenoid entourage effects. Br J Pharmacol 163:1344–1364. https://doi.org/10.1111/j.1476-5381.2011.01238.x
Russo EB, McPartland JM (2003) Cannabis is more than simply ∆9-tetrahydrocannabinol. Psychopharmacology (Berl) 165:431–432. https://doi.org/10.1007/s00213-002-1348-z
Schechter M, Pinhasov A, Weller A, Fride E (2012) Blocking the postpartum mouse dam’s CB1 receptors impairs maternal behavior as well as offspring development and their adult social–emotional behavior. Behav Brain Res 226:481–492. https://doi.org/10.1016/j.bbr.2011.10.016
Sharma P, Murthy P, Bharath MMS (2012) Chemistry, metabolism, and toxicology of cannabis: Clinical implications. Iran J Psychiatry 7:149–156
Siniscalco D, Sapone A, Giordano C et al (2013) Cannabinoid receptor type 2, but not type 1, is up-regulated in peripheral blood mononuclear cells of children affected by autistic disorders. J Autism Dev Disord 43:2686–2695. https://doi.org/10.1007/s10803-013-1824-9
Watanabe K, Yamaori S, Funahashi T et al (2007) Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes. Life Sci 80:1415–1419. https://doi.org/10.1016/j.lfs.2006.12.032
Gesetz zur Änderung betäubungsmittelrechtlicher und anderer Vorschriften. Bundesgesetzblatt Teil I 403
Volcano (2016) Volcano Vaporizer – Hochleistungsverdampfer. https://www.volcanovaporizer.com/eu/de/about/. Zugegriffen: 22. Juni 2019
DGuSV (2019) Definition Gutachter/Sachverständige. https://www.dgusv.de/gutachter-sachverstaendige-definition.html. Zugegriffen: 22. Juni 2019
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Interessenkonflikt
C. Wendelmuth: Referententätigkeit für Grünenthal GmbH, Kyowa Kirin GmbH, Aurora Deutschland GmbH. K. Gastmeier: Referententätigkeit für Bionorica ethics GmbH, Kyowa Kirin GmbH, Aurora Deutschland GmbH, Tilray Deutschland GmbH.
Für diesen Beitrag wurden von den Autoren keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien. Für Bildmaterial oder anderweitige Angaben innerhalb des Manuskripts, über die Patienten zu identifizieren sind, liegt von ihnen und/oder ihren gesetzlichen Vertretern eine schriftliche Einwilligung vor.
Rights and permissions
About this article
Cite this article
Wendelmuth, C., Gastmeier, K. Hochdosisdronabinoltherapie vs. Medizinalcannabisblüten. Schmerz 33, 392–398 (2019). https://doi.org/10.1007/s00482-019-00402-7
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00482-019-00402-7