Abstract
We examined a property of emulsion formation of propofol (ICI 35868) to release histamine into circulating plasma in dogs. Plasma histamine was measured with radioimmunoassay before (baseline), and 1,5 and 10 min after the administration of 15 mg·kg−1 propofol. There were no significant differences between the plasma histamine levels at 1, 5 and 10 min after the administration of propofol and the baseline level. We conclude that the emulsion formation of propofol of 15 mg·kg− 1 does not release histamine during induction of anesthesia in dogs.
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Mitsuhata, H., Shimizu, R. Plasma histamine levels during induction of anesthesia with propofol in dogs. J Anesth 7, 206–209 (1993). https://doi.org/10.1007/s0054030070206
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DOI: https://doi.org/10.1007/s0054030070206