Abstract
Autoimmunity is an important hypothesis in the etiology of vitiligo. Single-nucleotide polymorphisms (SNP) in protein tyrosine phosphatase nonreceptor 22 gene (PTPN22) have been linked with the development of several autoimmune diseases. In this study, we investigated the association between 1858C/T variant of the PTPN22 gene with non-segmental vitiligo in Egyptian females. One hundred female Egyptian patients suffering from non-segmental vitiligo and 120 age- and sex-matched normal Egyptian subjects were included in this study. The PTPN22 1858C/T genotypes were determined by a restriction fragment length polymorphism-polymerase chain reaction genotyping method. A nonsignificant difference in SNP in PTPN22 was found between patients and controls. The allelic frequency of 1858T (620 W) was 5 % in our patients as opposed to 12 % in controls (p = 0.17). No PTPN22 1858 TT homozygotes were observed among patients or controls. The results of this study showed no association between SNP in PTPN22 in Egyptian females with non-segmental vitiligo compared to control population. Future large scale studies are needed to confirm these results.
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Elmongy, N.N., Abu Khalil, R.E. PTPN22 gene polymorphism in Egyptian females with non-segmental vitiligo. Comp Clin Pathol 22, 961–964 (2013). https://doi.org/10.1007/s00580-012-1508-4
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DOI: https://doi.org/10.1007/s00580-012-1508-4