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Comparative efficacy of chamomile against omeprazole in aspirin-induced gastric ulcer in rats

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Abstract

The aim of the study was to compare the efficacy of chamomile versus omeprazole in the treatment of aspirin-induced gastric ulcer in rats. Animals were randomly assigned into three groups A, B and C (n = 10 each). Aspirin (200 mg/kg, intragastric (i.g.)) was administered for three consecutive days, and then, two animals from each group were euthanized and formed the aspirin-induced gastric ulcer control group. The remaining animals (n = 8 in each group) were administered with the following treatments: normal saline 9 % (0/5 mL, i.g.) (group A), omeprazole (2.3 mg/kg, i.p.) (group B) or chamomile decoction (25 mL/kg, i.g.) (group C) daily for 2 weeks. Histological analysis of tissue harvested from rats in groups B and C showed no significant difference, since ulcers in both treatment groups were completely cured. The results of this study suggest that chamomile could be used for the treatment of nonsteroidal anti-inflammatory drug-induced ulcers as an inexpensive alternative to omeprazole.

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Authors and Affiliations

  1. Garmsar Azad University, Gramsar, Iran

    Hadi Nomiri

  2. Small Animal Internal Medicine Department, Veterinary Faculty of Tehran University, Tehran, Iran

    Seyed Javid Aldavood

  3. Pathology Department, Medical Faculty of Shahed University, Tehran, Iran

    Reza Sedaghat

Authors
  1. Hadi Nomiri
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  2. Seyed Javid Aldavood
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  3. Reza Sedaghat
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Correspondence to Seyed Javid Aldavood.

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Nomiri, H., Aldavood, S.J. & Sedaghat, R. Comparative efficacy of chamomile against omeprazole in aspirin-induced gastric ulcer in rats. Comp Clin Pathol 23, 673–677 (2014). https://doi.org/10.1007/s00580-012-1669-1

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  • DOI: https://doi.org/10.1007/s00580-012-1669-1

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