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Association of Sitagliptin with cardiovascular outcome in diabetic patients: a nationwide cohort study

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Abstract

Aims

Although dipeptidyl peptidase-4 (DPP-4) inhibitor improves glycemic control, the actual cardiovascular outcomes remain unclear. The objective of this cohort study was to thus evaluate the cardiovascular outcome in diabetic patients who received DPP-4 inhibitors (Sitagliptin).

Methods

A total of 104,756 new diabetic patients were identified from the Taiwan National Health Insurance Research Database during the period from March 1, 2003 to December 31, 2011. Patients who received Sitagliptin therapy were included as exposures, and up to four age- and sex-matched controls were selected by risk-set sampling. Outcomes such as major adverse cardiovascular diseases (CVD) and deaths were assessed. Logistic regression models were applied to estimate the hazard ratios and 95 % CIs between DPP-4 inhibitor use and cardiovascular outcome.

Results

Over a mean of 14 months, the rates of total CVD per 1000 person-months were significantly lower in Sitagliptin users (3.41 vs. 5.17, p < 0.001), whereas other different CVDs (hazard ratio [HR] 0.59; 95 % confidence interval [CI] 0.48–0.72 for coronary heart disease; HR 0.75; 95 % CI 0.59–0.96 for ischemic stroke; HR 0.86; 95 % CI 0.45–1.65 for peripheral artery occlusive disease) and all-cause mortality (HR 0.56; 95 % CI 0.41–0.74]) were also fewer after adjustment for covariates.

Conclusions

The results showed a favorable outcome of Sitagliptin as a class on lowering CVD incidence in patients with type 2 diabetes.

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Acknowledgments

This study was supported by the Department of Internal Medicine, Chung Shan Medical University Hospital (CSH-2014-A-018), Taiwan. The authors thank Chiu-Ping Shang and Ai-Lun Yu for their assistance with regard to statistical analysis and data collection.

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Authors and Affiliations

  1. Institute of Medicine, Chung Shan Medical University, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan

    Tsung-Yuan Yang & Kai-Wei Chang

  2. Department of Family and Community Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan

    Yung-Po Liaw

  3. Department of Public Health and Institute of Public Health, Chung Shan Medical University, Taichung, Taiwan

    Jing-Yang Huang

  4. School of Medicine, Chung Shan Medical University, Department of Internal Medicine, Chung Shan Medical University Hospital, #110, Section 1, Jian-Guo North Road, Taichung, 402, Taiwan

    Horng-Rong Chang & Kwo-Chang Ueng

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  1. Tsung-Yuan Yang
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  2. Yung-Po Liaw
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  3. Jing-Yang Huang
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  5. Kai-Wei Chang
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Corresponding author

Correspondence to Kwo-Chang Ueng.

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Conflict of interest

The authors have no potential conflicts of interest directly relevant to the contents of this article.

Ethical standard

This study was approved by the ethical committee of Chung Shan Medical University Hospital.

Human and animal rights disclosure

This article does not contain any studies with human or animal subjects performed by any of the authors.

Informed consent

Informed consent was obtained from individual participants included in the study.

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Yang, TY., Liaw, YP., Huang, JY. et al. Association of Sitagliptin with cardiovascular outcome in diabetic patients: a nationwide cohort study. Acta Diabetol 53, 461–468 (2016). https://doi.org/10.1007/s00592-015-0817-x

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  • DOI: https://doi.org/10.1007/s00592-015-0817-x

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