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Risk factors for recurrence and retreatment after endovascular treatment of intracranial saccular aneurysm larger than 8 mm

  • Original Article - Vascular Neurosurgery - Aneurysm
  • Published:
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Abstract

Background

Large intracranial aneurysm is challenging for both surgical and endovascular treatment. High recurrence and retreatment rates are still limitations for endovascular treatment. Analysing risk factors of recurrence after endovascular treatment can be useful for planning future treatment strategies.

Method

We retrospectively reviewed patients with intracranial saccular aneurysm (≥ 8 mm) who underwent endovascular treatment from 2008 to 2017 at our institution. The demographic features, clinical information and angiographic results were analysed to reveal the risk factors for recurrence and retreatment. Subgroup analysis was performed according to packing density (PD) and stent insertion status.

Results

The total recurrence and retreatment rates were 25.7% (44/171) and 10.5% (18/171), respectively. Independent risk factors for recurrence after endovascular treatment were larger aneurysm size (OR 1.32; 95% CI 1.17–1.51; p < 0.001), ruptured status (OR 3.91; 95%CI 1.44–10.90; p = 0.008), initial incomplete occlusion (OR 2.72; 95%CI 1.18–6.41; p = 0.020), and low dome-to-neck ratio (OR 0.61; 95%CI 0.36–0.97; p = 0.047). The recurrence rate for the no-stent with low PD (< 17.5%) group was 50% (14/28); 37.5% (6/16) for stent-assisted coil (SAC) with low PD group, 22.0% (20/91) for no-stent with high PD group and 11.1% (4/36) for SAC with high PD group.

Conclusion

The independent risk factors for recurrence after endovascular treatment in large (≥ 8 mm) intracranial saccular aneurysm were larger aneurysm size, ruptured status, low dome-to-neck ratio and initial incomplete occlusion state. SAC is a useful method for lowering recurrence after endovascular treatment for relatively large (≥ 8 mm) cerebral aneurysm.

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Authors and Affiliations

  1. Department of Neurosurgery, College of Medicine, Seoul St Mary’s Hospital, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 137-701, Republic of Korea

    Yung Ki Park, Hong-Ju Bae, Jai Ho Choi & Yong Sam Shin

  2. Department of Radiology, College of Medicine, Seoul St Mary’s Hospital, The Catholic University of Korea, Seoul, Republic of Korea

    Dong Young Cho & Bum-Soo Kim

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  1. Yung Ki Park
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  2. Hong-Ju Bae
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Correspondence to Yong Sam Shin.

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All authors certify that they have no affiliations with or involvement in any organisation or entity with any financial interest (such as honoraria; educational grants; participation in speaker’s bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licencing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This study was approved by the institutional review board at the author’s institute (KC18RESI0538).

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This article is part of the Topical Collection on Vascular Neurosurgery - Aneurysm

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Park, Y.K., Bae, HJ., Cho, D.Y. et al. Risk factors for recurrence and retreatment after endovascular treatment of intracranial saccular aneurysm larger than 8 mm. Acta Neurochir 161, 939–946 (2019). https://doi.org/10.1007/s00701-019-03877-6

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  • DOI: https://doi.org/10.1007/s00701-019-03877-6

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