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Combined use of lactic-acid-producing bacteria as probiotics and rotavirus vaccine candidates expressing virus-specific proteins

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Abstract

Due to the lower efficacy of currently approved live attenuated rotavirus (RV) vaccines in developing countries, a new approach to the development of safe mucosally administered live bacterial vectors is being considered, using probiotic bacteria as an efficient delivery platform for heterologous RV antigens. Lactic acid bacteria (LAB), which are considered food-grade bacteria and normal microbiota, have been utilized throughout history as probiotics and developed since the 1990s as a delivery system for recombinant heterologous proteins. Over the last decade, LAB have frequently been used as a platform for the delivery of various RV antigens to the mucosa. Given the appropriate safety profile for neonates and providing the benefits of probiotics, recombinant LAB-based vaccines could potentially address the need for a subunit RV vaccine. The present review focuses mainly on different recombinant LAB vaccine constructs for RV and their potential as an alternative recombinant vaccine against RV disease.

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Funding

The present study was funded and supported by Pasteur Institute of Iran (Grant no. 881).

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  1. Atefeh Afchangi and Tayebeh Latifi contributed equally to this work.

Authors and Affiliations

  1. Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

    Atefeh Afchangi, Tayebeh Latifi, Somayeh Jalilvand & Sayed Mahdi Marashi

  2. Department of Molecular Virology, Pasteur Institute of Iran, Tehran, Iran

    Zabihollah Shoja

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Afchangi, A., Latifi, T., Jalilvand, S. et al. Combined use of lactic-acid-producing bacteria as probiotics and rotavirus vaccine candidates expressing virus-specific proteins. Arch Virol 166, 995–1006 (2021). https://doi.org/10.1007/s00705-021-04964-9

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