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A general palladium-catalyzed cross-coupling of aryl fluorides and organotitanium (IV) reagents

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Abstract

Pd(OAc)2/1-[2-(di-tert-butylphosphanyl)phenyl]-4-methoxy-piperidine was demonstrated to effectively catalyze cross-coupling of aryl fluoride and aryl(alkyl) titanium reagent. Both electron-deficient and electron-rich aryl fluoride can react effectively with nucleophile and provide extensive functional groups tolerance. 2-Arylated product was realized by selective activation of the C–F bond.

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Acknowledgements

The author gratefully acknowledge the financial support from Hebei Chemical & Pharmaceutical College and the Higher Education Scientific Research Project of Hebei Province (2020) (SQ201044). The author is thankful to Hebei University of Science & Technology for 13C NMR, 1H NMR, HRMS (ESI) measurement.

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  1. Department of Chemistry and Environmental Engineering, Hebei Chemical and Pharmaceutical College, Shijiazhuang, People’s Republic of China

    Xiao-Yun He

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  1. Xiao-Yun He
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Correspondence to Xiao-Yun He.

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He, XY. A general palladium-catalyzed cross-coupling of aryl fluorides and organotitanium (IV) reagents. Monatsh Chem 152, 823–832 (2021). https://doi.org/10.1007/s00706-021-02796-6

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  • DOI: https://doi.org/10.1007/s00706-021-02796-6

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