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Sleep-inducing effect of lettuce (Lactuca sativa) varieties on pentobarbital-induced sleep

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Abstract

The objective of this study was to investigate the sleep-inducing effect of lettuce varieties and the extracts derived from romaine lettuce on pentobarbital-induced sleep. Romaine lettuce had a higher lactucin content (red romaine: 361.50 µg/g of extract, green romaine: 1071.67 µg/g of extract) compared to the green and red lettuce varieties. The seed and leaf extracts derived from romaine lettuce induced an increase in the sleep duration at low and high doses respectively. The seed extract of romaine lettuce showed higher content of polyphenols, including caftaric acid, chlorogenic acid, and chicoric acid, compared to the leaf extract. The IC50 value of the leaf extract for its DPPH radical-scavenging was significantly less (0.11 mg/mL) than that of the seed extract (0.21 mg/mL) (p < 0.05). Romaine lettuce is an interesting and valuable source of sleep potentiating material and contains antioxidant phenolics that protect from the oxidant stress caused by sleep disturbance.

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Acknowledgement

This research was supported by the Ministry of Trade, Industry and Energy (MOTIE) and the Korea Institute for Advancement of Technology (KIAT) through the Encouragement Program for The Industries of Economic Cooperation Region.

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Authors and Affiliations

  1. Department of Integrated Biomedical and Life Sciences, Graduate School, Korea University, Seoul, 02841, Korea

    Hae Dun Kim

  2. Department of Biological Sciences and Environmental Science Program, Southern Illinois University-Edwardsville, Edwardsville, IL, 62026, USA

    Ki-Bae Hong

  3. Department of Hotel Culinary Arts and Nutrition, Kaya University, Gimhae, 50830, Korea

    Dong Ouk Noh

  4. Department of Public Health Science, Graduate School, Korea University, Seoul, 02841, Korea

    Hyung Joo Suh

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  1. Hae Dun Kim
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Correspondence to Hyung Joo Suh.

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Kim, H.D., Hong, KB., Noh, D.O. et al. Sleep-inducing effect of lettuce (Lactuca sativa) varieties on pentobarbital-induced sleep. Food Sci Biotechnol 26, 807–814 (2017). https://doi.org/10.1007/s10068-017-0107-1

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  • DOI: https://doi.org/10.1007/s10068-017-0107-1

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